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All Journal JSFK (Jurnal Sains Farmasi & Klinis) Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society KIAN Journal Journal of Pharmaceutical and Sciences. Jurnal Ilmiah Farmasi Simplisia Ad-dawaa: Journal Of Pharmacy Indonesian Journal of Medical and Pharmaceutical Science
Nurkholis, Fiqih
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Evaluation of the rationality of using antibiotics in orthopedic surgery patients at the Cilacap Regional General Hospital using the Gyssens method Permana, Fadli Bayu; Sofiah, Siti Asadu; Salfia, Wa Ode; Nurkholis, Fiqih
Ad-Dawaa : Journal of Pharmacy Vol. 2 No. 2 (2024): Ad-Dawaa: Journal of Pharmacy (November 2024)
Publisher : LPPM STIKes Muhammadiyah Ciamis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52221/dwj.v2i2.765

Abstract

A fracture is a condition of severing or damage to the cartilage, bone structure, or epiphysis, which is divided into open and closed fractures. Open fractures require antibiotic therapy to prevent infection, given the high risk of infection. Evaluation of the rationality of antibiotic use is very important to ensure effective therapy and prevent side effects, ineffective treatment, high costs, and antibiotic resistance. Antibiotic resistance can increase infections that are difficult to treat and increase morbidity and mortality. This study aims to evaluate the rationality of antibiotic use in orthopedic surgery patients at Cilacap Regional Hospital using the Gyssens method. The study was observational and collected retrospective data from 55 patients who underwent orthopedic surgery for open fractures in 2023. The data used for analysis included patient identity, diagnosis, laboratory data, and antibiotic use. The results obtained were category 0 (appropriate and rational use of antibiotics) 37%, category II A (inappropriate dosage) 10%, category II B (inappropriate administration interval) 1%, category III B (administration of antibiotics too short) 9%, category IV A (presence of other more effective antibiotics) 1%, category IV C (presence of cheaper antibiotics) 39%, category VI (incomplete patient data) 4%. The conclusion shows that there are still many antibiotic prescriptions that do not meet category 0, indicating the need for improvement in the rationality of antibiotic use at Cilacap Regional Hospital.
Implementation of Interprofessional Health Education-based Research Based on Discipline, Practice, Dissemination Trends and Research Design: A Literature Review Nurkholis, Fiqih
KIAN JOURNAL Vol 2 No 2 (2023): KIAN JOURNAL (September 2023)
Publisher : Yayasan Inspirasi El Burhani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/kian.v2i2.308

Abstract

Objective: The World Health Organization (WHO) started a program in 2007 to promote Interprofessional Education (IPE) and its benefits for collaborative practice. Many IPE reviews have examined what has been done and how effective it is. This review aimed to investigate the methods and outcomes of IPE research. Methods: IPE research examined the following: 1) disciplines involved; 2) writing patterns, 3) assessment focus, and 4) dissemination trends. Abstracts were screened prior to full-text screening, review, data extraction, analysis and audit. Categorical data were reported with frequencies and percentages while continuous data were reported with means and standard deviations. Chi-square analysis was used to test for differences between groups for categorical variables. Results: Of the 359 articles that met the criteria, most were written by authors from medical, nursing, and pharmacy schools, using quantitative or mixed techniques. Most studies involved student disciplines with no authors from those disciplines. Most studies also measured student perceptions and knowledge, with a few measuring faculty perceptions. Research was mostly conducted in classrooms, simulations, and field experiences. IPE research was published in 98 journals, most of which were interdisciplinary journals, with the largest increase in publications in the last year of the review. Conclusions: The field of IPE research has grown significantly in the last decade. It is important to explore different ways to conduct IPE research, plan ways to disseminate IPE results, and ensure that all disciplines of students involved in IPE are represented in authorship.
Antibiotic Use for Genitourinary Infections in an Indonesian Hospital During COVID-19: A Retrospective Study Abely, Nastasya Anis; Fauziah, Fauziah; Kurniasih, Khamdiyah Indah; Nurkholis, Fiqih; Kusuma, Ikhwan Yuda
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 3 (2024): J Sains Farm Klin 11(3), December 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.3.153-160.2024

Abstract

The management of genitourinary infections presents a growing challenge due to antimicrobial resistance, shifting regional patterns, and evolving etiologies. This study aimed to elucidate antibiotic utilization trends and patterns for genitourinary system diseases at an Indonesian teaching hospital during the COVID-19 pandemic. This retrospective, cross-sectional study analyzed antibiotic use in an Indonesian teaching hospital's inpatient department in 2021. Data on systemic antibiotics (ATC: J01) for genitourinary diseases (ICD-10: N00-N99) were extracted from electronic records. Prescription patterns were evaluated by patient characteristics, disease profiles, administration routes, and WHO AWaRe classification. Among the 47,696 hospitalized patients who received antibiotics, 1,752 were treated with J01 antibiotics for genitourinary disorders, mostly in elderly men with prostatic hyperplasia and obstructive uropathy. Cephalosporins, especially ceftriaxone (724 prescriptions) and cefazolin (294 prescriptions), were the most commonly prescribed, while amoxicillin/beta-lactamase inhibitors were the least prescribed. Parenteral administration was more common than oral, and "Watch" category antibiotics were prescribed twice as often as "Access" antibiotics in adults and the elderly. Genitourinary disorders like prostatic hyperplasia and obstructive uropathy significantly impact elderly men. This study reveals a trend of high broad-spectrum antibiotic use, such as ceftriaxone and cefazolin injections, in hospitalized patients with these conditions.
Evaluasi Penggunaan Obat Pada Pasien Geriatri Yang Memiliki Kemungkinan Interaksi Obat Berdasarkan Beers Criteria Di Rumah Sakit Umum Daerah Cilacap Adityas, Hanung Puspita; Nurkholis, Fiqih; Hartono, Nurvadila Iqmalia
Indonesian Journal of Medical and Pharmaceutical Science Vol. 4 No. 1 (2025)
Publisher : Sultan Agung Islamic University of Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v4i1.212

Abstract

Background: The increasing elderly population poses its own challenges, particularly in the field of health. The elderly tend to experience degenerative diseases and often have multiple chronic conditions. This can lead to the use of multiple medications (polypharmacy). Drug interactions occur when one medication affects the activity of another. These interactions can be pharmacokinetic or pharmacodynamic. The Beers Criteria is a tool used to detect Potentially Inappropriate Medications (PIMs) and identify drugs that may pose greater risks than benefits for elderly patients aged ≥ 65 years. Methods: This research uses descriptive method and is an observational study with a cross-sectional approach, measuring variables by collecting data through patient geriatric questionnaire. It aims to evaluate medication use in geriatric patients who may have drug interactions at Cilacap Regional General Hospital. Results: This research shows that female patients are more numerous, with 53 individuals (53.53%), while male patients amount to 46 individuals (46.46%). Patients in the age range of 60-74 years are 94 individuals (94.94%), and those in the age range of 75-90 years are 50 individuals (5.05%). Patients receiving <5 medication therapy are 57 individuals (57.57%), while those receiving >5 medications are 42 individuals (42.42%). The most commonly used medication among geriatric patients is candesartan, with 46 prescriptions (9.82%). The research results indicate that the medications falling under Potentially Inappropriate Medications (PIMs) according to the 2023 Beers criteria are mostly in category 1, totaling 81 medications (50.63%). Conclusion: The occurrence of Potentially Inappropriate Medications (PIMs) in geriatric patients at the outpatient department of Cilacap Regional General Hospital during the period of July-August 2024, based on the Beers Criteria 2023, shows that the largest percentage is attributed to glimepiride with 25 cases (17.606%). This indicates that prescribing PIMs to geriatric patients still involves potentially inappropriate drugs, necessitating attention from healthcare professionals to ensure safe and effective prescribing for this population.
Tingkat Penggunaan Antibiotik dan Pola Peresepannya Pada Infeksi Saluran Pernapasan (ICD-10: J00-J99) di Indonesia Selama Pandemi COVID-19 Misworo, Misworo; Kusuma, Ikhwan Yuda; Kurniasih, Khamdiyah Indah; Nurkholis, Fiqih; Fauziah , Fauziah
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.849

Abstract

Introduction: Respiratory tract infections (RTIs) contribute substantially to global antibiotic consumption, raising concerns about antimicrobial resistance (AMR). This study aimed to analyze antibiotic prescribing patterns for respiratory disorders in an Indonesian teaching hospital during the COVID-19 pandemic. Methods: This retrospective, cross-sectional study examined systemic antibiotic prescriptions based on the Anatomical Therapeutic Classification (ATC: J01) for respiratory diseases (ICD-10: J00-J99) at Cilacap Government Teaching Hospital between January and December 2021. Data were extracted from electronic medical records (e-MR), including patient demographics (i.e. age and sex), ICD codes and name of antibiotics. We analyzed WHO AWaRe classifications, administration routes, and seasonal patterns based on patient’s entry and antibiotic use. Results: The study included 2,395 patients with antibiotic prescriptions for respiratory disorders. The Watch group antibiotics accounted for 85.6% of prescriptions, with the highest use among adults (86.2%). Parenteral administration (71.5%) was more common than oral administration (28.5%). Pneumonia (38.2%) and chronic obstructive pulmonary disease (27%) were the most common indications. Antibiotic use peaked in December (n=529) and was lowest in July (n=84). Ceftriaxone (n=838), azithromycin (n=270), cefixime (n=262), levofloxacin (n=216), and meropenem (n=56) were among the top prescribed antibiotics. Conclusion: The study highlights the predominant use of broad-spectrum and parenteral antibiotics for respiratory disorders, raising concerns about AMR. Factors such as seasonality, disease patterns, and diagnostic challenges may have influenced prescribing practices. Implementing antimicrobial stewardship programs, promoting evidence-based guidelines, and addressing modifiable risk factors are crucial to combat AMR and optimize patient outcomes during and beyond the COVID-19 pandemic.
Pelatihan Pemanfaatan Limbah Minyak Jelantah Menjadi Lilin Aromaterapi Di Desa Windujaya Kurniasih, Khamdiyah Indah; Samodra, Galih; Setianingsih, Siti; Nurkholis, Fiqih; Hakim, Lukman
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 4, No 1 (2025)
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/phar.soc.v4i1.31247

Abstract

Minyak jelantah adalah minyak yang telah digunakan secara berulang-ulang hingga 3-4 kali penggorengan. Dampak negative dari minyak goreng bekas jika dibuang begitu sajatanpapengolahanakanmenjadilimbahdanakanmerusaklingkungansekitar.Salahsatubentuk  produk hasil pengolahan minyak goreng bekas adalah lilin aromaterapi. Sasaranmitra  pengabdian ini adalah masyarakat ekonomi non produktif di desaWindujaya yang bekerja bekerja sebagai Ibu Rumah Tangga dan tidak memiliki penghasilan. UrgensiPemberdayaan Masyarakat Pemula ini meningkatkan keterampilan Kelompok Kader DesaWindujaya dalam Pelatihan Pembuatan lilin aromaterapi yang berbahan dasar limbah minyak jelantah. Tujuan kegiatan ini yaitu, meminimalisasipembuangan minyak jelantah, berubahnya pola hidup masyarakat untuk mengolah limbahminyak jelantah berbasis zero waste industry, berkurangnya pembuangan minyak jelantahdisembarang tempat dapat mengurangi resiko pencemaran air tanah, dan erciptanya produklilinaromaterapidansabunbernilaiekonomis. Kegiatan ini telah terlaksana pada tanggal 18 agustus 2024 dengan peserta ibu rumah tangga yang ada di Desa Winduajaya, Banyumas. Metode Kegiatan ini menggunakan metode difusi ilmu pengetahuan dan teknologi (ipteks) dengan tahapan berupa tahapan persiapan dan koordinasi terkait dengan pengetahuan Masyarakat terhadap lombah minyak jelantah ,Pemberdayaan Masyarakat, monitoring dan evaluasi serta sasaran pelatihan.  Hasil pengabdian didapat bahwa terdapat peningkatan pengetahuan terkait pemanfaatan limbah minyak jelantah dalam bentuk lilin aromaterapi.
Drug Utilization Review of Antibiotics in Geriatric Outpatients at Cilacap Regional General Hospital During the COVID-19 Pandemic Safitri, Cindy Ade; Kurniasih, Khamdiyah Indah; Fauziah, Fauziah; Nurkholis, Fiqih; Kusuma, Ikhwan Yuda
JURNAL ILMIAH FARMASI SIMPLISIA Vol. 5 No. 2 (2025): Desember 2025
Publisher : Jurusan Farmasi, Politeknik Kesehatan Kementerian Kesehatan Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/jifs.v5i2.850

Abstract

Infectious diseases are challenging for the geriatric due to higher infection risk and atypical symptoms, leading to more diagnostic uncertainty. This study aimed to evaluate antibiotic use patterns among geriatric outpatients at Cilacap Regional General Hospital in Indonesia during the COVID-19 pandemic. A retrospective study analyzed electronic medical records of geriatric outpatients who received antibiotics from January to December 2021. Data collected included demographic characteristics, types of antibiotics based on the AWaRe classification, route of administration, ICD-10 codes, and antibiotic use. The results showed that the age group of 65–69 years was the most frequent user of antibiotics, with solid oral formulations being the most commonly prescribed. Most antibiotics prescribed belonged to the Watch category, such as cefixime and levofloxacin. The most common diagnosis based on ICD-10 codes was Z098. These findings indicate a tendency toward the use of broad-spectrum antibiotics, which poses a risk of increasing antibiotic resistance. Therefore, stricter antibiotic stewardship interventions and continuous education are necessary to improve the rational use of antibiotics in the geriatric population.
Analysis of Antibiotic Drug Utilization in Pediatric Pneumonia Patients at Cilacap Regional Public Hospital Using the ATCDDD Method and DU 90% Nurkholis, Fiqih
Viva Medika Vol 17 No 1 (2024)
Publisher : Universitas Harapan Bangsa Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35960/vm.v17i1.1437

Abstract

The high incidence of infectious pneumonia will increase the use of antibiotics. This disease is a leading cause of death in children under 5 years of age. This study aims to describe the utilization of antibiotics for pneumonia in pediatric patients aged ≤ 5 who were treated at RSUD Cilacap in 2022. The research method used was a descriptive study with retrospective data collection, referring to medical record data. Samples were taken using the total sampling method and evaluated using the ATC/DDD and DU 90% methods. The results showed that male pediatric patients were more prevalent (55.55%) with the highest age group being 0-1 years (40.27%). The most frequently used antibiotic was Ceftriaxone (45.06%). The highest DDD/100 bed days value was for Azithromycin at 52.14, and the lowest DDD/100 bed days value was for Metronidazole at 0.31. The antibiotic with the highest DU 90% value was Azithromycin (65.18). The results of the study can be concluded that elevated overall DDD/100 days value suggests that the greater the utilization of antibiotics within a 100-day treatment period, while the extensive inclusion of drugs in 90% DU segment indicates a less discerning approach to antibiotic selection in therapy
Co-Authors Abely, Nastasya Anis Adityas, Hanung Puspita Fauziah , Fauziah Fauziah Fauziah Hartono, Nurvadila Iqmalia Ikhwan Yuda Kusuma Kurniasih, Khamdiyah Indah Lukman Hakim Misworo, Misworo Permana, Fadli Bayu Safitri, Cindy Ade Salfia, Wa Ode Samodra, Galih Siti Setianingsih Sofiah, Siti Asadu