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All Journal Medical Sains : Jurnal Ilmiah Kefarmasian
Gianto, Vinie Regina Putri
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Medicine & Pharmacology

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IN VITRO ANTIBACTERIAL ACTIVITY OF CARICA PAPAYA LEAF EXTRACT-LOADED ACNE PATCHES AGAINST Propionibacterium acnes Indriaty, Sulistiorini; Rizikiyan, Yayan; Gianto, Vinie Regina Putri; Karlina, Nina; Hidayati, Nur Rahmi; Sulastri, Lela; Firmansyah, Deni
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1673

Abstract

Acne vulgaris is a prevalent skin condition that is characterized by inflammatory lesions. Propionibacterium acnes is a key bacterium implicated in its pathogenesis. This study aimed to investigate the antibacterial potential of Carica papaya leaf extract against P. acnes and its efficacy when formulated into acne patches. Ethanolic extracts of C. papaya leaves were prepared at concentrations of 20%, 25%, and 30%. These extracts were incorporated into acne patch formulations and evaluated for antibacterial activity using the paper disc diffusion method. Clindamycin 1% was used as a positive control and 70% ethanol was used as a negative control. The results demonstrated that all concentrations of the C. papaya leaf extract exhibited significant antibacterial activity against P. acnes. The 30% concentration demonstrated the largest zone of inhibition, which was comparable to that of the positive control. These findings suggest that C. papaya leaf extract-based acne patches are promising natural alternatives for the treatment of acne vulgaris. Keywords: Papaya leaves (Carica papaya L), Propionibacterium acne, Acne patch, Inhibitory power
IN VITRO ANTIBACTERIAL ACTIVITY OF CARICA PAPAYA LEAF EXTRACT-LOADED ACNE PATCHES AGAINST Propionibacterium acnes Indriaty, Sulistiorini; Rizikiyan, Yayan; Gianto, Vinie Regina Putri; Karlina, Nina; Hidayati, Nur Rahmi; Sulastri, Lela; Firmansyah, Deni
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1673

Abstract

Acne vulgaris is a prevalent skin condition that is characterized by inflammatory lesions. Propionibacterium acnes is a key bacterium implicated in its pathogenesis. This study aimed to investigate the antibacterial potential of Carica papaya leaf extract against P. acnes and its efficacy when formulated into acne patches. Ethanolic extracts of C. papaya leaves were prepared at concentrations of 20%, 25%, and 30%. These extracts were incorporated into acne patch formulations and evaluated for antibacterial activity using the paper disc diffusion method. Clindamycin 1% was used as a positive control and 70% ethanol was used as a negative control. The results demonstrated that all concentrations of the C. papaya leaf extract exhibited significant antibacterial activity against P. acnes. The 30% concentration demonstrated the largest zone of inhibition, which was comparable to that of the positive control. These findings suggest that C. papaya leaf extract-based acne patches are promising natural alternatives for the treatment of acne vulgaris. Keywords: Papaya leaves (Carica papaya L), Propionibacterium acne, Acne patch, Inhibitory power
Co-Authors Deni Firmansyah Lela Sulastri, Lela Nina Karlina Nur Rahmi Hidayati, Nur Rahmi Sulistiorini Indriaty Yayan Rizikiyan