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All Journal Siber International Journal of Education Technology Dinasti Information and Technology Dinasti Accounting Review Jurnal Kewirausahan dan Multi Talenta (JKMT) Dinasti Health and Pharmacy Science Siber International Journal of Advanced Law Jurnal Greenation Pertanian dan Perkebunan
Ananta, Yorasakhi
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Agriculture, Biological Sciences & Forestry Humanities Computer Science & IT Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Social Sciences Other

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The Role of Proteolytic Activity and Computational Studies on Protease Efficiency in Wound Healing Ananta, Yorasakhi; Fitri, Salsabila Dwi
Dinasti Health and Pharmacy Science Vol. 2 No. 2 (2024): Dinasti Health and Pharmacy Science (October 2024)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v2i2.1820

Abstract

Microbial proteases play an important role in various medical applications, especially in the wound healing process. Their proteolytic activity allows the breakdown of proteins involved in the inflammatory process and tissue regeneration. This study aims to review the role of microbial proteolytic activity in wound healing and explore the application of computational studies to predict the effectiveness of proteases in wound therapy. Molecular modeling and in silico prediction are used to identify potential proteases that are efficient in improving wound healing. This study also includes an analysis of the mechanism of action of proteases on biological molecules in wounds, as well as the challenges and prospects of using microbial proteases in modern medical therapy.
Literature Review on Characterization and Optimization of Protease Enzymes for Medical Applications Ananta, Yorasakhi
Dinasti Health and Pharmacy Science Vol. 2 No. 2 (2024): Dinasti Health and Pharmacy Science (October 2024)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v2i2.1824

Abstract

Protease enzymes are a group of enzymes that play an important role in protein breakdown and have been widely studied for medical applications, especially in the fields of wound healing, cancer therapy, and antimicrobials. This article presents a systematic review of various studies exploring the biochemical characterization and optimization of protease enzyme activity produced by microorganisms. The main focus of this review includes the optimum conditions for enzyme activity, stability to pH and temperature, and genetic engineering and fermentation methods for increasing its production. It was found that thorough characterization is very important in determining the potential for clinical application of protease enzymes. In addition, optimization of enzyme production through fermentation and biotechnology approaches has been shown to increase efficiency and reduce the risk of side effects in medical applications. This review provides a comprehensive overview of the progress and challenges in the development of proteases for use as therapeutic agents.
The Role of Bacillus pseudomycoides Isolates and Bioinformatics Modeling for Modern Pharmaceutical Applications: A Literature Review Ananta, Yorasakhi; Fitri, Salsabila Dwi
Dinasti Health and Pharmacy Science Vol. 2 No. 3 (2025): Dinasti Health and Pharmacy Science (January 2025)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v2i3.1832

Abstract

This article presents a literature review on the role of Bacillus pseudomycoides isolates as protease enzyme producers and how bioinformatics modeling enhances their potential in modern pharmaceutical applications. B. pseudomycoides is known to produce proteases with superior characteristics such as temperature and pH stability, making them potential candidates for pharmaceutical formulations. Bioinformatics approaches such as protein structure modeling, molecular docking, and genomic analysis have accelerated the functional characterization of these enzymes. The combination of the utilization of microorganisms and computational approaches opens up new opportunities in drug development, wound therapy, and pharmaceutical biotechnology. This study recommends multidisciplinary integration in the utilization of microbial resources for future therapeutic needs.
The Role of Bacterial Protease Enzymes and In Silico Prediction on the Effectiveness of Medical Applications Muliawan, Adi; Ananta, Yorasakhi; Fitri, Salsabila Dwi
Dinasti Health and Pharmacy Science Vol. 2 No. 4 (2025): Dinasti Health and Pharmacy Science (April 2025)
Publisher : Dinasti Research & Yayasan Dharma Indonesia Tercinta (DINASTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dhps.v2i4.1841

Abstract

Bacterial protease enzymes have a wide range of medical applications, particularly in the treatment of infected wounds and therapy for protein digestion disorders. Proteases produced by bacteria such as Bacillus pseudomycoides show great potential for medical therapy due to their ability to break down proteins in the human body. In silico prediction using bioinformatics software such as AutoDock and PyMOL allows researchers to analyze the three-dimensional structure and molecular interactions of proteases with target substrates before conducting laboratory experiments. This article examines the role of bacterial protease enzymes in medical applications and the benefits of using in silico prediction to study the therapeutic potential of proteases. With a combined approach of experimentation and in silico analysis, the process of developing protease-based therapies can be more efficient and faster. This study emphasizes the importance of bioinformatics approaches in accelerating the discovery of enzyme-based medical therapies for future clinical applications.
Pengaruh Etika Bisnis dan Transparansi Informasi terhadap Kepercayaan Konsumen dalam Transaksi B2C di Indonesia: Kajian Literatur Fitri, Salsabila Dwi; Ananta, Yorasakhi
Jurnal Kewirausahaan dan Multi Talenta Vol. 3 No. 4 (2025): Jurnal Kewirausahan dan Multi Talenta (Oktober - Desember 2025)
Publisher : Siber Nusantara Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/jkmt.v3i4.529

Abstract

Dalam era digital, model bisnis Business to Consumer (B2C) berkembang pesat seiring meningkatnya konsumsi daring di Indonesia. Kepercayaan konsumen menjadi elemen krusial dalam menjaga keberlangsungan hubungan jangka panjang antara pelaku usaha dan pelanggan. Artikel ini bertujuan mengkaji peran etika bisnis dan transparansi informasi terhadap kepercayaan konsumen dalam konteks transaksi B2C di Indonesia melalui pendekatan kajian literatur sistematis. Penelusuran dilakukan pada berbagai sumber ilmiah dari database daring seperti Google Scholar, Mendeley, dan jurnal nasional, dengan fokus pada penelitian yang terbit dalam lima tahun terakhir. Hasil kajian menunjukkan bahwa penerapan etika bisnis yang konsisten dan transparansi informasi yang tinggi berkontribusi signifikan terhadap peningkatan kepercayaan konsumen. Artikel ini menyimpulkan bahwa kedua faktor tersebut saling melengkapi dan perlu diintegrasikan dalam strategi pemasaran digital B2C agar tercipta loyalitas dan keberlanjutan usaha.
Dinamika Pertumbuhan Bakteri Pengurai pada Biofilter Air Limbah Domestik di Bawah Variasi pH dan Suhu Ananta, Yorasakhi
Jurnal Greenation Pertanian dan Perkebunan Vol. 3 No. 2 (2025): (JGPP) Jurnal Greenation Pertanian dan Perkebunan (Mei 2025)
Publisher : Greenation Publisher & Yayasan Global Research National

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/jgpp.v3i2.583

Abstract

Pengolahan air limbah domestik berbasis biofilter memanfaatkan aktivitas bakteri pengurai sebagai komponen utama dalam menurunkan kandungan bahan organik dan pencemar. Pertumbuhan dan aktivitas bakteri pengurai dalam sistem biofilter sangat dipengaruhi oleh faktor lingkungan, khususnya pH dan suhu, yang menentukan stabilitas komunitas mikroba serta efisiensi degradasi senyawa organik. Artikel ini bertujuan untuk mengkaji secara sistematis dinamika pertumbuhan bakteri pengurai pada biofilter air limbah domestik di bawah variasi pH dan suhu berdasarkan hasil-hasil penelitian terdahulu. Metode yang digunakan adalah literature review dengan menelaah artikel ilmiah nasional dan internasional yang relevan, terutama yang membahas pengaruh pH dan suhu terhadap laju pertumbuhan mikroba, pembentukan biofilm, serta kinerja penyisihan parameter pencemar seperti BOD, COD, dan TSS. Hasil kajian menunjukkan bahwa kondisi pH netral hingga sedikit basa dan suhu mesofilik merupakan kondisi optimum bagi pertumbuhan bakteri pengurai dan pembentukan biofilm yang stabil. Variasi ekstrem pH dan suhu dilaporkan dapat menurunkan aktivitas metabolik mikroorganisme dan menyebabkan ketidakstabilan sistem biofilter. Dengan demikian, pengendalian pH dan suhu merupakan faktor kunci dalam optimasi kinerja biofilter untuk pengolahan air limbah domestik. Kajian ini diharapkan dapat menjadi dasar ilmiah dalam perancangan dan pengoperasian sistem biofilter yang lebih efektif dan berkelanjutan.
Co-Authors Fitri , Salsabila Dwi Fitri, Salsabila Dwi Muliawan, Adi Putra, Heldy Eka Putri, Yumna Syaza Kani