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All Journal Majalah Farmasetika Journal of Health Management and Pharmacy Exploration (JOHMPE)
Pratiwi, Yunia
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Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Antioxidant and trombolitic activity of etanol extract and fractions of carica culver (Carica pubescens) in vitro Pratiwi, Yunia; Mardiyono, Mardiyono; Indrayati, Ana
Journal of Health Management and Pharmacy Exploration Vol. 3 No. 1 (2025): February 2025
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v3i1.533

Abstract

The prevalence of degenerative diseases arising from cell damage and free radicals continues to increase. The reactivity of oxidant compounds that exceed the limit can form a chain reaction capable of damaging parts of blood vessel cells that cause thrombolysis. Carica skin waste (Carica pubescens) has not been widely utilized, carica skin has the potential to have the ability as an antioxidant and thrombolytic. This study aims to determine the potential antioxidant and thrombolytic activity of carica peel. Carica peel samples were extracted by remaceration method using 70% ethanol and then fractionated with n-hexane, ethyl acetate, and water solvents. Antioxidant activity testing was carried out using the DPPH (2.2 Diphenyl-1-picrylhydrazyl) method and thrombolytic activity with the clot lysis method. The results showed that the ethyl acetate fraction had the highest antioxidant activity compared to ethanol extract and other fractions with an IC50 value of 37.04 ppm with an AAI value of 0.54. The thrombolytic activity test of ethyl acetate fraction is also the highest thrombolytic agent with clot lysis value reaching 46.06% close to the clot lysis value of nattokinase positive control of 52.39%.
Identifikasi Alkaloid Ekstrak Etanol dan Fraksi Kulit Carica pubescens dengan Kromatrografi Lapis Tipis Pratiwi, Yunia; Dewi, Ratna Sari
Majalah Farmasetika Vol 11, No 2 (2026)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v11i2.69882

Abstract

Tanaman Carica pubescens merupakan komoditas dataran tinggi yang berpotensi sebagai sumber senyawa bioaktif. Optimalisasi pemanfaatan limbah kulit buah Carica memerlukan data ilmiah mengenai kandungan metabolit sekunder, khususnya golongan alkaloid yang memiliki aktivitas farmakologis luas. Penelitian ini bertujuan untuk melakukan identifikasi kualitatif senyawa golongan alkaloid pada ekstrak etanol dan fraksi kulit buah Carica (Carica pubescens) menggunakan metode Kromatografi Lapis Tipis (KLT). Ekstraksi dilakukan secara remaserasi dengan etanol 70%, dilanjutkan fraksinasi bertingkat (n-heksan, etil asetat, dan air). Analisis KLT menggunakan fase diam silika gel GF254 dan fase gerak metanol-kloroform (0,5:9,5) dengan pembanding piperin serta pereaksi semprot Dragendorff. Hasil analisa ekstrak etanol dan fraksi etil asetat menunjukkan hasil respon positif alkaloid dengan terbentuknya bercak jingga kecokelatan, dengan nilai Rf 0,94 serupa dengan nilai Rf baku pembanding piperin. Berdasarkan hasil profil kromatografi mendukung dugaan keberadaan senyawa golongan alkaloid secara kualitatif.
Co-Authors Ana Indrayati Fachry Abda El Rahman Ratna Sari Dewi