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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Batik-Mu : Jurnal Pengabdian Masyarakat
Ainin, Shabrina
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Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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A Design and Evaluation of a SNEDDS-Based System for Temu Ireng (Curcuma aeruginosa Roxb.) Extract: Enhancing Antioxidant Efficacy Using the SLD Technique Waznah , Urmatul; Oktaviani, Riska Kurnia Oktaviani; Ainin, Shabrina; Khafid, M. Iskandar; Mugiyanto, Eko
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 1: March 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i1.30268

Abstract

Temu Ireng (Curcuma aeruginosa Roxb.) is known for its strong antioxidant properties, primarily due to its bioactive compounds such as curcumin. However, these chemicals' lipophilia and instability in traditional formulations frequently limit their bioavailability. To address these challenges, a Self-Nanoemulsifying Drug Delivery System (SNEDDS) was developed using the Simple Lattice Design (SLD) method to improve the chemical and physical properties of Temu Ireng extract by forming a stable nanoemulsion that is uniformly distributed in the digestive system. This study aimed to formulate and evaluate a SNEDDS of Temu Ireng extract using the SLD approach, with a focus on enhancing its antioxidant activity. The formulation involved selecting suitable oils, surfactants, and cosurfactants, followed by optimization based on solubility studies, phase diagrams, and thermodynamic stability tests. The SNEDDS was characterized for physical properties such as emulsification time, transmittance, particle size, zeta potential, and polydispersity index. The optimized SNEDDS formulation exhibited excellent characteristics, including an emulsification time of less than 1 minute, near 100% transmittance, a particle size of 9.77 ± 1.33 nm, zeta potential of 0.9 ± 0.1 mV, and a polydispersity index of 0.302 ± 0.033. Antioxidant testing using the DPPH method showed that the 0.1% SNEDDS formulation of Temu Ireng extract had an inhibition concentration (IC50) value of 58.482 mg/L, indicating strong antioxidant activity. The results suggest that the SNEDDS formulation using the SLD method could be an effective strategy to enhance the bioavailability and therapeutic efficacy of Temu Ireng extract as an antioxidant agent.
SKRINING KESEHATAN REMAJA DALAM RANGKA PENCEGAHAN DIABETES DI PERUMAHAN LIMAS KRAPYAK PEKALONGAN Waznah, Urmatul; Rahmasari, Khusna Santika; Ningrum, Wulan Agustin; Azzahra, Nafisa Aufa; Ainin, Shabrina
Batik-MU : Jurnal Pengabdian Masyarakat Vol. 4 No. 1 (2024): Batik-MU
Publisher : Fakultas Ilmu Kesehatan Universitas Muhammadiyah Pekajangan Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48144/batikmu.v4i1.1806

Abstract

Peningkatan kadar gula darah dalam tubuh di atas nilai normal menyebabkan gangguan metabolisme yang dikenal sebagai diabetes meliatus. Tingkat prevalensi diabetes di Indonesia saat ini berada di urutan kelima di seluruh dunia.Meskipun penyakit diabetes melitus tidak dapat disembuhkan, menerapkan pola hidup sehat dapat mencegahnya. Pentingnya pemeriksaan gula darah dan pencegahan sejak dini menjadi upaya untuk menekan penyebaran penyakit diabetes dilingkup remaja yang kurang disadari akan berdampak besar dimasa mendatang. Kegiatan pengabdian masyarakat ini bertujuan untuk memeriksa kadar gula darah remaja dan menganalisis strategi pencegahan diabetes sejak usia dini. Sasaran kegiatan pengabdian masyarakat ini adalah remaja putri warga perumahan limas krapyak pekalongan. Hasil pemeriksaan kadar gula darah menunjukan 100 % remaja tidak ada yang melebihi normal.
Co-Authors Azzahra, Nafisa Aufa Eko Mugiyanto, Eko Khafid, M. Iskandar Khusna Santika Rahmasari Ningrum, Wulan Agustin Oktaviani, Riska Kurnia Oktaviani Urmatul Waznah Waznah , Urmatul