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Meliana, Dias Feni
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Physics Public Health Social Sciences

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Antibacterial and Antifungal Activities of Pandanus amaryllifolius Leaf Extract, Fractions, and Isolate and Their Role in Anti-Dandruff Shampoo Optimization Wijayanti, Rina; Susmayanti, Windi; Meliana, Dias Feni; Fauziyah, Afifah Husnun; Anjeline, Aprilia Mega; Putri, Devyra Yunika Mutiara Sari Suwarto; Ulya, Fadhia Tafrichatul
Sciences of Pharmacy Volume 4 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0402299

Abstract

Pandan leaves (Pandanus amaryllifolius Roxb.) possess various biological activities due to their secondary metabolites, including flavonoids, alkaloids, phenolics, saponins, and triterpenoids/steroids. This study aimed to evaluate the antibacterial and antifungal activities of pandan leaf extracts, fractions, and isolates against Staphylococcus aureus, Escherichia coli, and Pityrosporum ovale, as well as to optimize surfactants in shampoo formulations. The experimental design used a post-test-only control group. Samples were processed through maceration, followed by fractionation and isolation using the KLT-P method. Antibacterial and antifungal activities were assessed using the agar well diffusion method. The most effective antibacterial activity against E. coli was observed in the n-hexane isolate at 700 ppm, with an inhibition zone of 19.6 mm, classified as strong. For S. aureus, the 100% water fraction produced an inhibition zone of 9.96 mm, classified as weak. The ethanol extract showed antifungal activity against P. ovale with an inhibition zone of 6.29 mm, categorized as moderate. Shampoo formulation optimization using sodium lauryl sulfate and cocamide DEA resulted in an ideal ratio of 0.235 to 0.764. This combination produced a shampoo with acceptable physical characteristics, including a pH of 5.71, foam height of 2.56 cm, and viscosity of 899.9 cps, all of which met the standard requirements.
ANALISIS TINGKAT PENGETAHUAN DAN PERILAKU MASYARAKAT TENTANG ANTIBIOTIK SECARA RASIONAL DI APOTEK WARAS BAROKAH SEMARANG Meliana, Dias Feni; Kusuma, Zamal Daud Dandhy; Fatiha, Chilmia Nurul
SAINS INDONESIANA Vol. 3 No. 1 (2025): Vol. 3, No. 1 Edisi Februari 2025
Publisher : Gamma Publishing

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Abstract

Antibiotik adalah golongan senyawa sinstetis atau alami yang mampu dalam menghentikan atau menekan proses biokimia terhadap suatu organisme. Resistensi antibiotik saat ini menjadi ancaman terbesar bagi kesehatan masyarakat global, sehingga WHO mengkoordinasi kampanye global untuk meningkatkan kesadaran dan perilaku masyarakat terhadap antibiotik. Penelitian tentang Tingkat Pengetahuan dan Perilaku Masyarakat Terhadap Penggunaan Antibiotik dilakukan menggunakan metode cross sectional, yang bertujuan untuk menganalisis tingkat pengetahuan dan perilaku masyarakat mengenai penggunaan antibiotik yang rasional. Pengumpulan data dilakukan dengan memberikan kuesioner tertutup. Sampel sebanyak 70 responden di Apotek waras barokah. Hasil penelitian menunjukan masyarakat sekitar Apotek Waras barokah memiliki pengetahuan dan perilaku yang cukup baik yakni (62%) dan (84%). Hasil uji chi square menunjukan nilai p 0,839 yakni >0,05 menunjukan tidak ada hubungan antara pengetahuan dan perilaku penggunaan antibiotik
Co-Authors Anjeline, Aprilia Mega Chilmia Nurul Fatiha Fauziyah, Afifah Husnun Kusuma, Zamal Daud Dandhy Putri, Devyra Yunika Mutiara Sari Suwarto Rina Wijayanti Susmayanti, Windi Ulya, Fadhia Tafrichatul