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Hafizhoh, Itsnainiyah
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Earth & Planetary Sciences Education Electrical & Electronics Engineering Materials Science & Nanotechnology Physics

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Pemodelan Pola Perambatan Gelombang Kalsium Pada Jaringan Astrocyte Dengan Simulator Brian2 Hafizhoh, Itsnainiyah; Yuniati, Anis
Sunan Kalijaga Journal of Physics Vol. 2 No. 2 (2020): Sunan Kalijaga Journal of Physics
Publisher : Prodi Fisika Fakultas Sains dan Teknologi UIN Sunan Kalijaga Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/physics.v2i2.2291

Abstract

Calcium wave propagation pattern modeling has been successfully carried out in astrocyte network using Brian2 simulator. The astrocyte model is defined by the Li-Rinzel equation which involves the IP3Rs (q) activation fraction. IP3Rs activation fraction parameter (q) affects the value of calcium concentration in astrocytes. The connection between astrocyte is in the form of Gap-Junction Channels (GJCs). The variation in this modeling is the number of astrocyte cells stimulated by external currents in the astrocyte network being modeled. The modeling results show that the IP3Rs (q) activation fraction can affect the propagation of calcium waves in astrocytes through activation of IP3 receptors
Pemodelan Struktur Dan Mekanisme Interaksi Neuron-Astrocyte Dalam Proses Transfer Informasi Dengan Simulator Brian2 Hafizhoh, Itsnainiyah; Yuniati, Anis
Sunan Kalijaga Journal of Physics Vol. 2 No. 2 (2020): Sunan Kalijaga Journal of Physics
Publisher : Prodi Fisika Fakultas Sains dan Teknologi UIN Sunan Kalijaga Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/physics.v2i2.2293

Abstract

The modeling of neuron-astrocyte interactions in neural networks has been successfully carried out using the Brian2 simulator. The neuron model used is Integrate and Fire, while the astrocyte network model is defined by the Li-Rinzel equation which involves the IP3Rs (q) activation fraction which affects the value of calcium concentration in astrocytes. Interaction modeling between neuron networks and astrocytes involves four types of connections, namely connections between neurons connected by synapses, connections between astrocytes in the form of gap-junction channels (GJCs), synaptic connections to astrocytes and astrocyte connections to synapses. The synaptic connection to the astrocytes is made to trigger the activation of the astrocytes by releasing the neurotransmitter. The astrocyte connection to the synapses is established as a route for the production of the gliotransmitter. The modeling results show that the information transfer mechanism carried out by neurons is in the form of electric current wave propagation, while the information transfer carried out by astrocytes is in the form of calcium wave propagation.
Co-Authors Yuniati, Anis