Sunan Kalijaga Journal of Physics
Vol. 2 No. 2 (2020): Sunan Kalijaga Journal of Physics

Pemodelan Struktur Dan Mekanisme Interaksi Neuron-Astrocyte Dalam Proses Transfer Informasi Dengan Simulator Brian2

Hafizhoh, Itsnainiyah (Unknown)
Yuniati, Anis (Unknown)



Article Info

Publish Date
15 Nov 2020

Abstract

The modeling of neuron-astrocyte interactions in neural networks has been successfully carried out using the Brian2 simulator. The neuron model used is Integrate and Fire, while the astrocyte network model is defined by the Li-Rinzel equation which involves the IP3Rs (q) activation fraction which affects the value of calcium concentration in astrocytes. Interaction modeling between neuron networks and astrocytes involves four types of connections, namely connections between neurons connected by synapses, connections between astrocytes in the form of gap-junction channels (GJCs), synaptic connections to astrocytes and astrocyte connections to synapses. The synaptic connection to the astrocytes is made to trigger the activation of the astrocytes by releasing the neurotransmitter. The astrocyte connection to the synapses is established as a route for the production of the gliotransmitter. The modeling results show that the information transfer mechanism carried out by neurons is in the form of electric current wave propagation, while the information transfer carried out by astrocytes is in the form of calcium wave propagation.

Copyrights © 2020






Journal Info

Abbrev

physics

Publisher

Subject

Earth & Planetary Sciences Education Electrical & Electronics Engineering Materials Science & Nanotechnology Physics

Description

Sunan Kalijaga Journal of Physics (SKJP) is peer-reviewed journal published twice a year by the Department of Physics, Faculty of Science and Technology, Universitas Islam Negeri (UIN) Sunan Kalijaga Yogyakarta-Indonesia. SKJP publishes original research articles on all the major, also the branches ...