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Irmi Syafa'ah
Ph.D. Program in Graduate Institute of Biomedical Science, College of Medicine, China Medical University, Taichung, Taiwan.

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Prevalence of Metabolic Disease in Patients with Chronic Obstructive Pulmonary Disease (COPD) at Universitas Airlangga Hospital, Surabaya, Indonesia Muhammad Muhajir; Arief Bakhtiar; Satriyo Dwi Suryantoro; Wiwin Is Effendi; Irmi Syafa'ah; Farah Fatma Wati
Jurnal Respirasi Vol. 12 No. 2 (2026): May 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.2.2026.109-115

Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) is a major global health problem and remains one of the three leading causes of death worldwide. In addition to respiratory impairment, COPD is often associated with systemic inflammation that contributes to metabolic disorders such as hypertension, diabetes mellitus (DM), dyslipidemia, and obesity. However, data on the prevalence of these comorbidities in Indonesia remain limited. This study aimed to determine the prevalence of metabolic disorders among COPD patients at Universitas Airlangga Hospital in Surabaya, Indonesia. Methods: This retrospective descriptive study reviewed the medical records of COPD patients with metabolic disorders treated at Universitas Airlangga Hospital, Surabaya, Indonesia, from January to December 2024. Thirty-two patients aged >40 years old with complete data were included. Variables assessed included age, gender, smoking history, the Brinkman Index, Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage, the Modified Medical Research Council (mMRC) Dyspnea Scale, and components of metabolic disorders. Patients with incomplete medical records were excluded. The findings were summarized in tables and figures. Results: All patients were male (100%), with a mean age of 61.7±7.07 years old; the majority were 61-70 years old (56.25%). A history of smoking was present in 84.38% of patients, predominantly with a moderate Brinkman Index. The GOLD stage 2 (40.63%) and mMRC grade 0 (56.25%) were the most common. Metabolic disorders were highly prevalent, including: hypertension (81.26%), obesity (50.0%), dyslipidemia (37.50%), and DM (28.13%). Most patients had multiple overlapping disorders. Conclusion: Metabolic disorders were highly prevalent among COPD patients, with hypertension being the most common. Multiple coexisting metabolic disorders were more frequent than single conditions.
Bilateral Multiple Lower Limb Tuberculous Aneurysms in a Pregnant Woman with Drug-Induced Liver Injury due to Tuberculosis Treatment Farah Almadina; Kana Wulung Arie Ichida Prinasetyo; Dewi Roziqo; Irmi Syafa'ah
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.256-262

Abstract

Introduction: Tuberculosis (TB) is a long-term infectious disease caused by Mycobacterium tuberculosis (MTB). It can occur during pregnancy, in which its treatment can cause side effects, such as drug-induced liver injury (DILI). Tuberculous aneurysm due to TB infection is a rare occurrence, which can spread directly and hematogenously from the vascular wall. We report a case of bilateral multiple lower limb tuberculous aneurysms in a pregnant woman with DILI due to TB treatment. Case: A 27-year-old pregnant woman at 14-15 weeks of gestation presented with painless lumps on the left side of her neck and both ankles. Fine needle aspiration biopsy (FNAB) of the left cervical lymph nodes confirmed tuberculous lymphadenitis. Vascular Doppler ultrasound of both lower limbs revealed multiple aneurysms, suspected to be infected tuberculous aneurysms with intramural thrombi, located on the lateral and anterior aspects of the distal leg extending to the left ankle, compressing the distal posterior and anterior tibial arteries. After one month of category one anti-TB drug (ATD) therapy, the patient developed elevated bilirubin levels (3.76 mg/dL). Following surgical intervention, the anti-TB regimen was resumed, leading to the resolution of the pseudoaneurysms by the fifth month of treatment. Conclusion: Tuberculous aneurysm in pregnant patients with TB is a rare and potentially life-threatening condition. It is difficult to diagnose, but TB infection should be considered a possible cause in endemic countries. Surgery combined with anti-TB treatment improves outcomes.
Conservative Management of Chest Tube and Ambulatory Water Sealed Drainage in Persistent Pneumothorax due to Tuberculosis Ni Wayan Candrawati; Franciscus Sanjaya; Irmi Syafa'ah
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.263-268

Abstract

Introduction: Pneumothorax is characterized by the presence of air in the pleural cavity, which can result from various pulmonary conditions, including tuberculosis (TB). Conservative management, including the use of chest tubes with ambulatory water-sealed drainage (WSD), offers a viable alternative for patients who are ineligible for surgery or decline surgical intervention. This case report aimed to highlight that all treatment options should be discussed with the patient to determine their primary priority, with consideration for the least invasive option. Case: A 22-year-old woman with secondary spontaneous pneumothorax due to TB presented with shortness of breath following a cough and was found to have a >2cm lucent area on chest X-ray. Initial management included chest tube insertion and WSD. A persistent pneumothorax was identified after 13 days of admission, and surgery was advised, but the patient declined. Conservative management was continued with ambulatory drainage for a total of 34 days, and management of TB as an underlying disease, and adequate nutritional support. Over the course of a month, clinical symptoms improved, and subsequent evaluations confirmed resolution of the pneumothorax. The chest tube was removed. The patient completed 12 months of anti-TB therapy, was declared cured, and experienced no recurrence of pneumothorax. Conservative management, including ambulatory WSD, effectively manages persistent air leak (PAL) for patients unsuitable for surgery. Ambulatory WSD facilitates mobility, reduces hospital stay, and minimizes complications. Proper patient education, nutritional support, and management of underlying conditions are essential for favorable outcomes. Conclusion: The management of persistent pneumothorax should be guided by the patient’s clinical condition. Conservative management can yield favorable results, followed by best supportive management.
Predicting Prolonged Hospitalization in Pneumonia: The Role of Lung Injury Score Mayandra Alif Anggita Putri; Isnin Anang Marhana; Arief Rakhman Hakim; Arief Bakhtiar; Irmi Syafa'ah
Jurnal Respirasi Vol. 12 No. 1 (2026): January 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.1.2026.27-34

Abstract

Introduction: Pneumonia is a lung infection with a high prevalence and is associated with prolonged length of stay (LOS). An excessive LOS increases the risk of complications, while a short LOS may lead to inadequate treatment. The lung injury score (LIS), which assesses the severity of lung injury and respiratory dysfunction, is expected to be an accurate predictor of LOS in patients with pneumonia. This study aimed to determine the correlation between LIS and LOS in hospitalized patients with pneumonia. Methods: This retrospective cohort study included adult patients hospitalized at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, with a diagnosis of pneumonia between January and December 2023. The LIS component scores (chest X-ray findings, arterial partial pressure of oxygen-to-fractional inspired oxygen ratio, positive end-expiratory pressure (PEEP), and static lung compliance) were obtained from electronic medical records and used to calculate LIS values. The correlation between LIS and LOS was analyzed using the Spearman test, while the cut-off point was determined using receiver operating characteristic (ROC) curve analysis. Results: A total of 152 patients fulfilled the inclusion criteria. The mean LIS was 1.82±0.89, while the mean LOS was 10.23±6.27 days. A statistically significant correlation was found between LIS and LOS (p<0.001) with a correlation coefficient of 0.317. Receiver operating characteristic curve analysis identified the optimal LIS cut-off point for an LOS of 10 days as 1.75. Conclusion: There was a statistically significant correlation between LIS and LOS in patients with pneumonia. The LIS cut-off point of 1.75 for an LOS of 10 days was statistically significant.