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PENGARUH SUPLEMENTASI VITAMIN D TERHADAP NILAI PENGUKURAN FEV1/ FVC PADA PENDERITA ASMA TERKONTROL SEBAGIAN Donastin, Adyan; Bakhtiar, Arief; Maranatha, Daniel
Jurnal Ilmu Kesehatan dan Kesehatan Vol 1 No 1 (2017): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v1i1.617

Background:Airflow resistance in asthma caused by changes in the airways that is bronchoconstriction,airway edema, airway hyperresponsiveness and airway remodeling. Vitamin D supplementation is expectedto raise the value of the measurement of FEV1/ FVC in patients with asthma controlled in part through therole of vitamin D in terms of antiviral effects, atopic response, response improvement steroid and preventairway remodeling process.Objective:Comparing the measurement values of FEV1/ FVC in patients withasthma controlled most of which do not get supplemental vitamin D than getting supplemental vitaminD.Methods:This study is a randomized experimental simple study. This research was conducted in drSoetomo Hospital from June to July 2015. The sampling technique using consecutive sampling. Sampleswere divided into two groups each consisting of 14 samples which have earned a combined therapy ofinhaled corticosteroids and LABA. The control group that was not given additional vitamin Dsupplementation and the treatment group were given supplements of vitamin D for 1 month. Measurementand main result:Testing of data distribution using the ShapiroWilk method because the sample size is lessthan 50. The result of the difference in FEV1 / FVC with a paired sample t - test is known that in the controlgroup (not given additional vitamin D supplements) did not occur significant difference (p = 0.219> 0.05),while the treatment group (given additional vitamin supplements D) proved significant difference (p = 0.020<0.05) where the value of FEV1 / FVC after being given additional vitamin D supplements increased to96.071% of the initial conditions is 84.786%.Conclusions:The measurement values of FEV1/ FVC in patientswith asthma controlled most of which get vitamin D supplementation are the most significant increasecompared to the control group who did not receive supplementation ofvitamin D.

Correlation between Coenzyme Q10 Level Long-Term Steroid Inhalation in Patients with Bronchial Asthma Deny Perdana Putra1, Arief Bakhtiar2, Muhammad Amin2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3378

Background: The main therapy of asthma is inhaled steroids and is often used for long periods of time. Coenzyme Q10 is a potent antioxidant produced largely by mitochondria. Treatment of long-term oral steroids can cause mitochondrial damage which lowers the level of coenzyme Q10. Objective: To analyze the relationship between coenzyme Q10 levels and long-term steroid inhalation in asthma patients. Method: The study was conducted at Asthma Unit/COPD of Dr. Soetomo General Hospital Surabaya Indoensia, Pulmonology Unit of. Dr. M. Soewandhie General Hospital Surabaya Indonesia, and Pulmonology Unit of Universitas Airlangga Hospital Surabaya Indonesia. We measured coenzyme Q10 levels and the duration of inhaled steroid use in the subjects. The data were processed using computer statistics program. The correlation between coenzyme Q10 level and long-term steroid inhalation was analyzed using Pearson correlation test (p <0.05). Result: Coenzyme Q10 levels in all samples were normal and increasing. There was no low coenzyme Q10 level found in all samples. The result of Pearson’s correlation test between coenzyme Q10 level with longterm steroid inhalation showed r = -0.037; p = 0.848 (p> 0.05). Conclusion: There was no correlation between coenzyme Q10 level and long-term steroid inhalation found in this study.

Appropriate Antibiotic Use for Community-Acquired Pneumonia in Inpatient Settings and Its Impact on 30-days Readmission and Mortality Rate Rafida Sofi Kamila1, Maftuchah Rochmanti2*, Arief Bakhtiar3
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13817

Background: Community-Acquired Pneumonia (CAP) is a lower respiratory tract infection with bacteriaas the most frequent causative agent. Therapy for pneumonia includes appropriate antibiotic usage.Inappropriate antibiotic use supposedly increase 30-days readmission and mortality rate.Objective: To evaluate the antibiotic use and the impact of appropriate antibiotic use on the 30-daysreadmission and mortality of CAP patients in inpatient non-ICU settings.Method: A cross-sectional, analytic study was conducted. We collected data from Universitas Airlanggahospital’s medical record to obtain the details of antibiotic usage. Result were evaluated using the Gyssensalgorithm. A chi-square test was used to identify the impact of appropriate antibiotic use on the 30-daysreadmission and mortality.Result: A total of 90 patients with CAP fulfilled the inclusion criteria. One gram of ceftriaxone IV wasthe most prescribed antibiotic for therapy of CAP. The amount of appropriate antibiotic use is 85.6%. Fivepatients (5.6%) went through the 30-days readmission. There was no death reported. The statistical testbetween antibiotic use and 30-days readmission obtained p value=0.894 (p>0.05).Conclusion: There was no significant impact of appropriate antibiotic use on the 30-days readmission rateand the mortality rate could not be assessed.

PENGARUH SUPLEMENTASI VITAMIN D TERHADAP NILAI PENGUKURAN FEV1/ FVC PADA PENDERITA ASMA TERKONTROL SEBAGIAN Adyan Donastin; Arief Bakhtiar; Daniel Maranatha
Jurnal Ilmu Kesehatan dan Kesehatan Vol 1 No 1 (2017): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v1i1.617

Background:Airflow resistance in asthma caused by changes in the airways that is bronchoconstriction,airway edema, airway hyperresponsiveness and airway remodeling. Vitamin D supplementation is expectedto raise the value of the measurement of FEV1/ FVC in patients with asthma controlled in part through therole of vitamin D in terms of antiviral effects, atopic response, response improvement steroid and preventairway remodeling process.Objective:Comparing the measurement values of FEV1/ FVC in patients withasthma controlled most of which do not get supplemental vitamin D than getting supplemental vitaminD.Methods:This study is a randomized experimental simple study. This research was conducted in drSoetomo Hospital from June to July 2015. The sampling technique using consecutive sampling. Sampleswere divided into two groups each consisting of 14 samples which have earned a combined therapy ofinhaled corticosteroids and LABA. The control group that was not given additional vitamin Dsupplementation and the treatment group were given supplements of vitamin D for 1 month. Measurementand main result:Testing of data distribution using the ShapiroWilk method because the sample size is lessthan 50. The result of the difference in FEV1 / FVC with a paired sample t - test is known that in the controlgroup (not given additional vitamin D supplements) did not occur significant difference (p = 0.219> 0.05),while the treatment group (given additional vitamin supplements D) proved significant difference (p = 0.020<0.05) where the value of FEV1 / FVC after being given additional vitamin D supplements increased to96.071% of the initial conditions is 84.786%.Conclusions:The measurement values of FEV1/ FVC in patientswith asthma controlled most of which get vitamin D supplementation are the most significant increasecompared to the control group who did not receive supplementation ofvitamin D.

Diabetes Mellitus and History of Tuberculosis Treatment as Risk Factors of Developing Multidrug-Resistant Tuberculosis at TB Polyclinic Dr. Soetomo General Hospital 2019 - 2020 Muhammad Raihan Habibi; Arief Bakhtiar; Danti Nur Indiastuti; Resti Yudhawati Meliana
Jurnal Ilmiah Universitas Batanghari Jambi Vol 22, No 1 (2022): Februari
Publisher : Universitas Batanghari Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33087/jiubj.v22i1.1908

Multidrug-Resistant Tuberculosis (MDR TB) is a condition when Mycobacterium tuberculosis were resistant to Isoniazid and Rifampicin simultaneously, with or without being followed by other first-line Anti-Tuberculosis Drugs. Diabetic patients who also have TB are more susceptible to drug resistance. There is ample evidence noting that a history of previous TB treatment is one of the main factors contributing to the development of MDR TB. This study was a case-control study. The sample of this study was all patients from TB Polyclinic Dr. Soetomo Hospital who were diagnosed with pulmonary TB by pulmonologists on January 1, 2019 – December 31, 2020, who met the inclusion criteria. The data obtained were analyzed using the IBM SPSS Statistics 23 application with a binary logistic regression test.There were 178 samples of this study. MDR TB (65.8%) was the dominant resistance type in Drug-Resistant Tuberculosis (DR TB) patients. Patients with DM were 2.2 times more likely to develop MDR TB than patients without DM. Patients with histories of previous tuberculosis (TB) treatment tended to be three times more likely to develop MDR TB than new patients. Other factors such as age, sex, BMI, history of alcohol consumption, and history of smoking did not show a significant relationship with the incidence of MDR TB. Diabetes Mellitus comorbidity and history of previous Tuberculosis treatment were significant risk factors for developing MDR TB.

Kanker Paru dan Penatalaksanaannya Arief Bakhtiar; Bambang Soeprijanto
Jurnal Kedokteran Syiah Kuala Vol 6, No 1 (2006): Volume 6 Nomor 1 April 2006
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstr ak. Keluhan kanker paru terjadi akibat kelainan : intra pulmonal, intra torasik ekstra pulmonal, ekstra torasik metastatik, ekstra torasik non meiastatik. Prosedur diagnosa meliputi deteksi dini dan tindakan diagnostik lebih Ianjut yang secara garis besar dapat dibagi dua : Tindakan Non lnvasif ( CT Scan Toraks, Positron Emission Tomography (PET) Magnetic Resonance Imaging); dan tindakan invasif (Transthoracic Needle Aspiration, Fiber Optik Bronkoscopi, Endoscopic Ultrasound, Mediastinoskopi). Klasifikasi kanker paru jenis karsinorna bukan sel kecil berdasarkan TNM staging, sedangkan small cell lung carsinoma berdasarkan Veterans Administrasion Lung Cancer Study grup. Penatalaksanaan kanker paru bersifat multimodalitas terapi yang terdiri dari: pernbedahan, radiasi, kernoterapi, irnunoterapi, terapi hormonal dan tempi gen. (JKS 2006;1:23-38) Kata kunci : karsinorna bron.kogenik, diagnose, penatalaksanaan. Abstract. Lung cancer is caused by intrapulmonary, intrathoracic extrapulmonary, extrathoracic metastatic, and extra thoracic nonmetastatic abnormalities. The diagnosis procedure includes early detection and further diagnostic action which are divided into two: NonInvasive Action (Thoracic CT Scan, Positron Emission Tomography (PET), Magnetic Resonance Imaging) and invasive (Transthoracic Needle Aspiration, Fiber Optical Bronchoscopy, Endoscopic Ultrasound, Mediastinoscopy). The classification of carcinoma lung caricer of nonsmall cell carcinoma is based on TNM staging, whereas small cell lung Veterans Administrasion carcinoma is based on Lung Cancer Study Group. The treatment of lung cancer is identi lied as multi modality therapy consisting of surgery,radiation, chemotherapy, irnrnunotherapy, hormonal therapy and gene therapy. (JKS 2006;1:23-38) Keywords: carcinoma bronchogenic, diagnosis, treatment.

The Improvement of Community Knowledge, Attitudes and Practices After Covid-19 Socialization Siti Khaerunnisa; Irmi Syafa'ah; Citrawati Dyah Kencono Wungu; Gwenny Ichsan Prabowo; Retno Handajani; Indri Safitri; Harianto Notopuro; Ema Qurnianingsih; Lina Lukitasari; Ira Humairah; Arief Bakhtiar; Suwandito Suwandito; Susi Wahyuning Asih; Zuhrotul Eka Yulis Anggraeni; Ginanjar Sasmito Adi; Ely Rahmatika Nugrahani; Ayesie Natasha Zulka; Soetjipto Soetjipto
Folia Medica Indonesiana Vol. 57 No. 2 (2021): June
Publisher : Universitas Airlangga

This study determined community knowledge, attitudes, and practices after COVID-19 socialization in Rambipuji and Suci Village, Jember District, East Java, Indonesia. This study used the analytic observational design study. As many as 40 people were given socialization about COVID-19 by gathering and online. The questionnaires were completed in two parts included before-socialization and after-socialization. The questionnaire data were analyzed descriptively by calculating frequency, percentage, and inferential statistics by t-test, Spearman correlation, and chi-square test. The data analysis used IBM SPSS version 23 software. The mean and standard deviation of percentage of knowledge pre-test, knowledge post-test, high attitude, moderate attitude, low attitude, very high practice, high practice, sufficient practice, and low practice were 58.33 ± 30.97, 77.70 ± 22.52, 62.5±21.7, 31±22.2, 6.5±17.1, 65±13.8, 32.3±13.8, 1.25±2.4, 1.25±1.8, respectively. Knowledge pre-test and post-test correlated 0.819 (p=0.001) and a t-test with p=0.003. Attitudes and practices correlated with p=0.001. Socialization of COVID-19 was useful to improve the community knowledge, attitudes, and practices in Rambipuji and Suci Village, Jember District, East Java, Indonesia that could prevent the transmission and inhibit the spread of the COVID-19 pandemic in Indonesia. Furthermore, continuous encouragement of COVID-19 socialization in wide areas was recommended.

The Relationship between Physical Activity and FEV1/FVC in Asthmatics Andis Putri Nawangasri; Budiono Budiono; Arief Bakhtiar; Budi Sutikno; Esti Maulidya Suryaningrum; Dahlia Damayanti
Surabaya Physical Medicine and Rehabilitation Journal Vol. 4 No. 1 (2022): SPMRJ, FEBRUARY 2022
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/spmrj.v4i1.24726

Background: Physical activity is any body movement that requires energy expenditure. Minimum physical activities per day can bring good impact for asthmatic patients (e.g.,reduce asthma symptoms). Many asthmatic patients limit their physical activity, so they tend to be inactive.Aim: To analyze the relationship between physical activity level and FEV1/FVC in asthmatics.Material and methods: This was an analytic observational study with a cross-sectional design. The number of participants in this study was 16 respondents (13 females and 3 males) who were recruited based on inclusion and exclusion criteria. The independent variable in this study is levels of physical activity and the dependent variable is FEV1/FVC values. This study study used the International Physical Activity Questionnaire (IPAQ) short form and spirometry test. The data were analyzed with Spearman's rho test.Result: There was a strong association between levels of physical activity with FEV1/FVC values (p=0,012).Conclusions: Increasing level of physical activity in asthmatics can improve their lung function showed by increased FEV1/FVC values.

The Effect of Combination Pranayama Yoga and Endurance Training Exercise on Peak Expiratory Flow (PEF) in Adult Asthmatic Patients Akbar Nur; Kusnanto Kusnanto; Muhammad Amin; Muhammad Sajidin; Ninuk Dian Kurniawati; Arief Bakhtiar
Jurnal Keperawatan Padjadjaran Vol. 8 No. 2 (2020): Jurnal Keperawatan Padjadjaran
Publisher : Faculty of Nursing Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkp.v8i2.1350

Pranayama Yoga can help improve breathing, and improve calm and also relieve stress. Endurance training can increase lung capacity, improve fitness, and relax the body. However, the combination of pranayama yoga and endurance exercises has never been done in asthma patients. The purpose of this study was to analyze the combination of pranayama yoga exercises and endurance exercises for Increased Peak Forced Expiration Flow. The design of this study was Quasy Experiment with a pretest-posttest control group design, the location of the study was in the pulmonary clinic of Universitas Airlangga Hospital and Haji General Hospital in Surabaya, East java. Respondents were selected by purposive sampling techniques in accordance with inclusion criteria with a total of 72 respondents. Peak Expiration Flow is measured from forced vital capacity or The peak expiratory flow (PEF) is the maximum flow obtained within the first 200 milliseconds of a forced expiratory maneuver after inhalation to total lung capacity (TLC). The intervention group was given a combination exercise by doing pranayama yoga and endurance exercise for 6 weeks, 2x per week, 51 minutes for each training session. Pranayama yoga combination exercises and endurance exercise using trainer instructors and modules. FPEF and asthma control were measured every week for 6 weeks. The results showed a significant difference in the level of FPEF and asthma control before and after 6 weeks of interventions combination of pranayama yoga and endurance exercise in the intervention group obtained significance values (p <0.05) with p = 0.000 and asthma control in the intervention group (p <0, 05) with p = 0.000 the results of the research shows that by practicing pranayama yoga and endurance exercise can improve FPEF and asthma control. Pranayama yoga and endurance exercise can be used as an complementary therapy in supporting pharmacological therapy to improve FPEF and control asthma.

Correlation between FEV1% Predicted and Blood Eosinophils in Patients with Exacerbations of Chronic Obstructive Pulmonary Disease (COPD) Alfian Nurfaizi; Isnin Anang Marhana; Gadis Meinar Sari; Arief Bakhtiar
Jurnal Respirasi Vol. 7 No. 2 (2021): May 2021
Publisher : Faculty of Medicine Universitas Airlangga

Introduction: Chronic obstructive pulmonary disease (COPD) exacerbations are still the leading causes of mortality. Eosinophil counts were recommended in assessing the risk of exacerbations. This additional examination was preferred rather than the pulmonary function test (PFT), which was considered less precise and had vast differences. Therefore, an analysis of the correlation between the FEV1% predicted and blood eosinophil counts were needed as a reference in the diagnosis of COPD exacerbation. This study aimed to determine the correlation between FEV1% predicted and blood eosinophils counts in patients with COPD exacerbations.Methods: This was a retrospective cross-sectional study by analyzing medical records of patients with COPD exacerbations at Dr. Soetomo General Hospital, Surabaya, from 2017 to 2018.Results: The characteristics of patients with exacerbations of COPD consisted of 91.7% male patients. Most of them were in the age group of 61-70 years old, 58.3% were in the private sector, 75% had a high school diploma, and 41.7% had normal body mass index (BMI). The percentage of the FEV1% predicted is directly proportional to the percentage of blood eosinophils with weak and statistically insignificant strength.Conclusion: The FEV1% predicted and blood eosinophil counts had a very weak correlation and statistically insignificant strength. Thus, it could not be used as a reference for diagnosis using one of the variables. Further research is needed with sputum eosinophils and biopsy as consideration for more accurate results.

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