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All Journal Jurnal Berkala Epidemiologi Manuju : Malahayati Nursing Journal Jurnal Respirologi Indonesia Jurnal Respirasi (JR) JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Effendi, Wiwin Is
Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, Universitas Airlangga/Dr. Soetomo General Hospital, Surabaya, Indonesia.
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Appendicular Tuberculosis as Manifestation of Gastrointestinal Tuberculosis: A Case Report Yuliza Yuliza; Alfian Nur Rosyid; Wiwin Is Effendi; Prastuti Asta Wulaningrum; Herley Windo Setiawan
Jurnal Respirasi Vol. 7 No. 3 (2021): September 2021
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (344.745 KB) | DOI: 10.20473/jr.v7-I.3.2021.122-126

Abstract

Introduction: Gastrointestinal tuberculosis (GI TB) is quite rare with 3% incidence of all extrapulmonary involvement. Appendicular TB may occur in 0.1 - 3% of cases. Diagnosis is often difficult because the patient usually complains about chronic abdominal pain and fever. A definite diagnosis is based on histopathological examination of resected specimens from the appendectomy procedure.Case: We present a 37-year-old male patient admitted to the hospital with chronic abdominal pain, fever, nausea, and loss of body weight. The patient never had a persistent cough, hemoptysis, or night sweating. Physical examination showed pain and muscular rigidity in the right iliac area during palpation with Blumberg's sign and Rovsing's sign positive. Abdomen ultrasound imaging showed an appendicular abscess. The patient underwent appendectomy afterwards with histopathology result showing TB. The patient was treated with first category anti-tuberculosis drugs (ATD).Discussion: Diagnosis of appendicular TB is difficult due to unspecific clinical presentations. Appendicular TB patients often complain of signs and symptoms which are similar to acute appendicitis. These conditions can delay ATD treatment because the definitive diagnosis could be made after histopathological examination.Summary: Appendicular TB is a rare case of extrapulmonary TB. It can present as acute appendicitis. The definitive diagnosis is based on the histopathological examination. It is recommended to check the appendicectomy specimens histopathologically to exclude TB or other diseases. 
Profil Perilaku Merokok terhadap Kejadian TB Paru Mdr di RSUD Dr. Soetomo Periode Januari – Desember 2019 Hafidz Alfarobi; Wiwin Is Effendi; Abdul Khairul Rizki Purba; Alfian Nur Rosyid
Malahayati Nursing Journal Vol 4, No 12 (2022): Volume 4 Nomor 12 2022
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v4i12.7514

Abstract

ABSTRAK Merokok dapat menaikkan risiko penyakit paru-paru kronis, salah satunya TB Paru. Jumlah rokok per hari dapat memperburuk infeksi TB paru dan menyebabkan kegagalan konversi pada fase intensifikasi. Tujuan penelitian ini adalah untuk mengetahui profil perilaku merokok terhadap kejadian TB paru MDR di RSUD Dr. Soetomo Surabaya. Jenis penelitian ini adalah deskriptif observasional dengan metode retrospektif dan menggunakan data sekunder dari rekam medik pasien RSUD Dr. Soetomo Surabaya. Pengambilan sampel menggunakan total sampling. Hasil penelitian menunjukkan bahwa sebagian besar pasien TB paru MDR tidak merokok sebanyak 66 (56,4%) pasien, sebagian besar pasien TB paru MDR berumur 25- 45 tahun sebanyak 40 (34,2%) pasien dengan rata-rata umur 43,8 tahun, sebagian besar pasien TB paru MDR tidak memiliki penyakit komorbid sebanyak 68 (58,1%) pasien, sebagian besar pasien TB paru MDR berjenis kelamin laki-laki sebanyak 70 (59,8%) pasien, Rata-rata berat badan pasien TB paru MDR adalah 47,7 Kg, dan sebagian besar pasien dengan kejadian kambuh TB paru MDR sebanyak 43 (36,8%) pasien. Berdasarkan hasil perhitungan Chi-Square diperoleh p-value = 0,195 α = 0,05 (nilai p-value lebih besar dari α = 0,05). Hal ini berarti terdapat tidak hubungan yang signifikan antara perilaku merokok dengan kejadian TB paru MDR. Kata Kunci: Perilaku Merokok, TB Paru MDR, Profil  ABSTRACT Smoking can increase the risk of chronic lung diseases, one of which is pulmonary TB. The number of cigarettes per day can worsen pulmonary TB infection and cause conversion failure in the intensification phase. The purpose of this study was to determine the profile of smoking behavior on the incidence of MDR pulmonary TB in RSUD Dr. Soetomo Surabaya. This type of research is descriptive observational with a retrospective method and uses secondary data from the medical records of patients at RSUD Dr. Soetomo Surabaya. Sampling using total sampling. The results showed that most of the MDR pulmonary TB patients did not smoke as many as 66 (56.4%) patients, most of the MDR pulmonary TB patients aged 25-45 years were 40 (34.2%) patients with an average age of 43.8 years, most of the MDR pulmonary TB patients did not have comorbid diseases as many as 68 (58.1%) patients, most of the MDR pulmonary TB patients were male as many as 70 (59.8%) patients, the average body weight of MDR pulmonary TB patients was 47, 7 Kg, and most of the patients with MDR pulmonary TB relapsed as many as 43 (36.8%) patients. Based on the results of the Chi-Square calculation, p-value = 0.195 = 0.05 (p-value is greater than = 0.05). This means that there is no significant relationship between smoking behavior and the incidence of MDR pulmonary TB. Keywords: Smoking Behavior, MDR Pulmonary TB, Profil 
Prevalence of Lung Cancer with a History of Tuberculosis Nadira Putri Nastiti; Laksmi Wulandari; Sulistiawati Sulistiawati; Anna Febriani; Wiwin Is Effendi
Jurnal Respirasi Vol. 9 No. 2 (2023): May 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.2.2023.87-92

Abstract

Introduction: Lung cancer ranks as the second most common diagnosis of malignancy cases in the world with the highest mortality, while Indonesia is the country with the largest tuberculosis (TB) burden after India. Although these two diseases have a high incidence and mortality rate and are one of the main causes of health problems, coexistence between these two diseases is very rare. A similar clinical and radiological feature complicates the diagnosis and worsens the prognosis. This study aimed to determine the prevalence and distribution patterns of lung cancer incidence with a history of TB. Methods: This was a descriptive study. The data were obtained retrospectively from the electronic medical records of lung cancer patients from one roof oncology clinic, Dr. Soetomo General Hospital, Surabaya, in 2018–2020, meeting the inclusion and exclusion criteria. Results: Specifically, 76 out of 1,044 (7.3%) lung cancer patients had a history of TB, with the distribution being men (71.1%), in an age range of 50-59 years old (34.2%), who were active smokers (36.9%), had an adenocarcinoma type of cancer (90.8%), had a positive EGFR gene mutation (50%), and had a diagnosis of non–small cell lung cancer (NSCLC) during stage IV (79%) after a TB diagnosis (54%) with a time interval of 1 or >10 years. Conclusion: The prevalence of lung cancer with a history of TB was 7.3%. Lung cancer screening is important in TB patients after one or even >10 years of diagnosis to reduce the morbidity and mortality rates because of this risk of coexistence.
Lung Cancer: A Literature Review Yan Efrata Sembiring; Wiwin Is Effendi; Jeffrey Jeswant Dillon; Heroe Soebroto; Dhihintia Jiwangga Suta Winarno; Puruhito Puruhito; I Gusti Agung Made Adnyanya Putra; Abed Nego Okthara Sebayang; Sri Pramesthi Wisnu Bowo Negoro
Jurnal Respirasi Vol. 9 No. 3 (2023): September 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.3.2023.246-251

Abstract

Lung cancer is a cancer whose onset starts in the lungs where there is an abnormal cell growth that is very fast and uncontrolled. The abnormal cell growth is triggered by deoxyribonucleic acid (DNA) damage, including deletions in the DNA section, inactivation of tumor suppressor genes, activation of proto-oncogenes to oncogenes, the absence of apoptosis, and the activity of the telomerase enzyme. Lung cancer is initiated by oncogeneous activity and inactivation of tumor suppressor genes. Oncogenes are genes that help cells grow and divide and are believed to cause a person to develop lung cancer. In general, lung cancer is divided into two types, namely non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). World Health Organization (WHO) classifies lung cancer based on histopathology into 4 major cell types, namely SCLC, NSCLC which includes adenocarcinoma, squamous cell carcinoma (SCC), and large cell carcinoma (LCC). The difference between the two is that SCLC has a higher aggressiveness than NSCLC. Cancer treatment is based on the type, size, location and stage of the cancer, as well as the patient's overall condition.
ANALYSIS OF RISK FACTORS FOR DEATH IN PATIENTS WITH COVID-19 IN 2021 AT UNIVERSITAS AIRLANGGA HOSPITAL: Analisis Faktor Risiko Kematian Pada Penderita COVID-19 Tahun 2021 di Rumah Sakit Universitas Airlangga Ayunda Solehan, Zahra; Atikasari, Fitri; Dwi Artanti, Kurnia; Asta Wulaningrum, Prastuti; Is Effendi, Wiwin; Yi Li, Chung
Jurnal Berkala Epidemiologi Vol. 12 No. 3 (2024): Jurnal Berkala Epidemiologi (Periodic Epidemiology Journal)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V12I32024.230-237

Abstract

Background: Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by SARS-CoV2, first detected in China in 2019. This disease causes respiratory infections and significantly impacts global health. Purpose: This study aims to analyze the risk factors for mortality in COVID-19 patients at Universitas Airlangga Hospital in 2021. Methods: This observational analytical study uses a case-control design, including 168 samples with 64 cases and 64 controls. Secondary data from patient medical records at Universitas Airlangga Hospital, including age, gender, education, comorbidities, oxygen saturation, and length of stay. Chi-square tests analyzed the data with a 95% confidence level (α=5%). Results: The analysis revealed significant associations between COVID-19 mortality and several factors. Age (p=0.01; OR=3.24; 95%CI=1.57-6.65), gender (p=0.01; OR=2.2; 95%CI=1.17-4.02), education (p=0.00; OR=2.40; 95%CI=1.11-5.40), comorbidities (p=0.08; OR=2.50; 95%CI=1.26-4.91), and oxygen saturation (p=0.00; OR=5.40; 95%CI=117.10-2490.06) were significantly associated with COVID-19 mortality. Oxygen saturation was the most influential factor (p=0.00; OR=901.73; 95%CI=120.75-6733.48) associated with mortality. Conclusion: Age, gender, education, comorbidities, and oxygen saturation significantly affect Covid-19 mortality rates. This study highlights the importance of monitoring and managing these risk factors in managing COVID-19 at Universitas Airlangga Hospital.
The Role of Vitamin C Supplementation in Preventing Severity Progression in Mild and Moderate COVID-19 Patients at Universitas Airlangga Hospital Arifandi, Yoga Akbar; Rosyid, Alfian Nur; Indiastuti, Danti Nur; Effendi, Wiwin Is
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 16 No. 1 (2025): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V16I12025.63-69

Abstract

Highlights: The administration of different dosages of vitamin C significantly yields different outcomes in preventing the progression of disease severity. Most patients with mild and moderate coronavirus disease (COVID-19) did not demonstrate an escalation in disease severity.   Abstract Introduction: Coronavirus disease (COVID-19) is an infectious disease that increases pro-oxidant elements and decreases antioxidants. Vitamin C functions as a potent antioxidant in humans due to its electron-donating properties.  This study aimed to explain the impact of three distinct vitamin C supplementation dosages in preventing disease severity progression among mild and moderate COVID-19 patients. Methods: This retrospective study used secondary data from 100 medical records (n=100). The subjects were classified into three categories based on the vitamin C dosage. The data were analyzed using the International Business Machines Corporation (IBM) Statistical Package for Social Sciences (SPSS) version 26.0 for Windows. Results: Most of mild and moderate COVID-19 patients (78%) did not experience increased disease severity. Vitamin C supplementation significantly demonstrated a different outcome in preventing disease severity progression among the three groups (p=0.018). However, it did not significantly show any difference in reducing the duration of hospital stay (p=0.680). Conclusion: The impact of vitamin C supplementation on COVID-19 severity appeared to vary depending on the dosage administered. However, it did not affect the duration of the hospital stay.
Clinical and Radiological Characteristics of Pneumonia in COVID-19 Patients at First Admission of Dr. Soetomo General Academic Hospital, Surabaya, in June-August 2021 Pradnyandari, Anak Agung Sagung Putri; Hasan, Helmia; Setiawati, Rosy; Effendi, Wiwin Is
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 16 No. 2 (2025): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V16I22025.115-121

Abstract

Highlights: This was the first study that described the radiological features of pneumonia in COVID-19 patients at first admission to Dr. Soetomo General Academic Hospital, Surabaya, during the Delta wave. This study presented the gastrointestinal symptoms of COVID-19 patients with pneumonia.   Abstract Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gave rise to the coronavirus disease (COVID-19) pandemic. Pneumonia in COVID-19 can cause acute respiratory distress syndrome (ARDS), which could lead to damage to end organs. This study aimed to describe the clinical and radiological profile of pneumonia in COVID-19 patients at first admission to the emergency department of Dr. Soetomo General Academic Hospital, Surabaya, in June-August 2021. Methods: This was a single-center, descriptive study of COVID-19 patients with pneumonia (n=193) at their first admission to the emergency department of Dr. Soetomo General Academic Hospital, Surabaya, from June to August 2021. The demographic data, pre-existing comorbidities, clinical signs and symptoms, and radiological findings were collected from the electronic medical record and analysed using the International Business Machines Corporation (IBM) Statistical Package for Social Sciences (SPSS) version 26. Results: Out of all the COVID-19 patients included in the study (n=193), most of them were 18-64 years old (86.0%), and the majority were males (50.8%). Of 193 patients, 51.3% had pre-existing comorbidities. Most patients (95.9%) experienced pulmonary symptoms, with shortness of breath being the most common. On chest radiograph, 60.1% patients showed consolidation with central and peripheral predominance (60.6%) and bilateral lung involvement (91.2%). Conclusion: This study presented a description of the clinical and radiological findings in COVID-19 patients with pneumonia. Most of which showed extensive lesions on chest radiograph along with dyspnea, which may suggest that most patients were suffering from late-stage and severe COVID-19 with pneumonia. To confirm this suggestion, further research is needed.
The Predictive Factors of Mortality In COVID-19 In The Intensive Care Unit: A Retrospective Study From Universitas Airlangga Hospital Surabaya Wennas, Vindy Vanessa; Bakhtiar, Arief; Yusuf, Mochamad; Effendi, Wiwin Is
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.830

Abstract

Background: Coronavirus disease 2019 (COVID-19) poses a significant global challenge due to its highly transmissible nature and many positive cases and deaths. Myriad factors are known to affect the outcome of COVID-19 patients. Therefore, identifying predictive factors is essential for developing strategies to reduce mortality. Methods: An analytical observational retrospective study was conducted at Universitas Airlangga Hospital Surabaya from January to June 2021. A total of consecutive sampling was performed on all patients in the intensive care unit. Thirty-one variables were included and analysed using a two-step statistical analysis: univariate and multivariate logistic regression. Results: The mortality rate among 116 patients was 61.2%. The univariate analysis showed that dyspnoea, hypoxia, hyperglycaemia, and fever at admission were positively correlated with mortality. The multivariate analysis showed that fever (adjusted odds ratio [OR]=5) and hyperglycaemia (adjusted OR=8) at admission were independent predictors of mortality. Conclusion: Patients with hyperglycaemia or fever at admission face an increased likelihood of dying from COVID-19, with risks elevated by eight times and five times, respectively.
Prevalence of Metabolic Disease in Patients with Chronic Obstructive Pulmonary Disease (COPD) at Universitas Airlangga Hospital, Surabaya, Indonesia Muhammad Muhajir; Arief Bakhtiar; Satriyo Dwi Suryantoro; Wiwin Is Effendi; Irmi Syafa'ah; Farah Fatma Wati
Jurnal Respirasi Vol. 12 No. 2 (2026): May 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.2.2026.109-115

Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) is a major global health problem and remains one of the three leading causes of death worldwide. In addition to respiratory impairment, COPD is often associated with systemic inflammation that contributes to metabolic disorders such as hypertension, diabetes mellitus (DM), dyslipidemia, and obesity. However, data on the prevalence of these comorbidities in Indonesia remain limited. This study aimed to determine the prevalence of metabolic disorders among COPD patients at Universitas Airlangga Hospital in Surabaya, Indonesia. Methods: This retrospective descriptive study reviewed the medical records of COPD patients with metabolic disorders treated at Universitas Airlangga Hospital, Surabaya, Indonesia, from January to December 2024. Thirty-two patients aged >40 years old with complete data were included. Variables assessed included age, gender, smoking history, the Brinkman Index, Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage, the Modified Medical Research Council (mMRC) Dyspnea Scale, and components of metabolic disorders. Patients with incomplete medical records were excluded. The findings were summarized in tables and figures. Results: All patients were male (100%), with a mean age of 61.7±7.07 years old; the majority were 61-70 years old (56.25%). A history of smoking was present in 84.38% of patients, predominantly with a moderate Brinkman Index. The GOLD stage 2 (40.63%) and mMRC grade 0 (56.25%) were the most common. Metabolic disorders were highly prevalent, including: hypertension (81.26%), obesity (50.0%), dyslipidemia (37.50%), and DM (28.13%). Most patients had multiple overlapping disorders. Conclusion: Metabolic disorders were highly prevalent among COPD patients, with hypertension being the most common. Multiple coexisting metabolic disorders were more frequent than single conditions.
Co-Authors Abdul Khairul Rizki Purba Mustofa Indwiani Astuti Abed Nego Okthara Sebayang Anna Febriani Arifandi, Yoga Akbar Atikasari, Fitri Ayunda Solehan, Zahra Bakhtiar, Arief Dhihintia Jiwangga Suta Winarno Farah Fatma Wati Hafidz Alfarobi Hasan, Helmia Herley Windo Setiawan I Gusti Agung Made Adnyanya Putra Indiastuti, Danti Nur Irmi Syafa'ah Jeffrey Jeswant Dillon Kurnia Dwi Artanti Laksmi Wulandari Mochamad Yusuf Alsagaff Muhammad Muhajir Nadira Putri Nastiti Pradnyandari, Anak Agung Sagung Putri Prastuti Asta Wulaningrum Puruhito Puruhito Rosyid, Alfian Nur Satriyo Dwi Suryantoro Sembiring, Yan Efrata Setiawati, Rosy Soebroto, Heroe Sri Pramesthi Wisnu Bowo Negoro Sulistiawati Sulistiawati Wennas, Vindy Vanessa Yi Li, Chung Yuliza Yuliza