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p-Index From 2021 - 2026
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All Journal Indonesian Journal of Global Health research Indonesian Journal of Global Health Research
Bugis Mardina Lubis
Universitas Sumatera Utara & Adam Malik Hospital
Education Health Professions Languange, Linguistic, Communication & Media Nursing Public Health

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Infection Markers as Prediction of Neonatal Sepsis Cindy Clarissa Sirait; Bugis Mardina Lubis; Ika Citra Dewi Tanjung; Hendri Wijaya; Arlinda Sari Wahyuni; Ayodhia Pitaloka Pasaribu
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6066

Abstract

Neonatal sepsis is one of the most common causes of neonatal death in the first month of life. Neonatal sepsis often shows atypical clinical features include temperature instability, lethargy, skin changes, feeding problems, and many others. Isolation of bacteria from the culture is the gold standard for diagnosing sepsis, but this approach is frequently time-consuming and even in cases of negative blood cultures, sepsis cannot be conclusively ruled out, posing a major challenge in its diagnosis and management. Early diagnosis and timely intervention are essential to improve the prognosis of neonatal sepsis. Aim: The aim of this study is to discuss how infection markers can aid in the early identification of neonatal sepsis and what are the best infection markers to predict neonatal sepsis mortality. Method: This study assessed the diagnostic accuracies of infection marker used in the diagnosis of neonatal sepsis. Included studies were retrieved by searching three major databases (Google Scholar, Pubmed, and Science Direct) using MeSH words and relevant references, and reviewed based on the inclusion/exclusion criteria. The article discusses potential advancements and future prospects for biomarkers. An excellent marker can guide antibiotic administration and duration if sepsis is confirmed, reducing unnecessary use. The marker should have high sensitivity, specificity, positive predictive value, negative predictive value and accuracy.
Prognostic Significance of Increasing pSOFA Scores in Paediatric Sepsis Nadia Setianingsih; Yunnie Trisnawati; Arlinda Sari Wahyuni; Bugis Mardina Lubis; Hendri Wijaya; Rosmayanti Syafriani Siregar
Indonesian Journal of Global Health Research Vol. 8 No. 1 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i1.238

Abstract

Sepsis is a major cause of morbidity and mortality among children worldwide, particularly in low- and middle-income countries. Early identification and continuous monitoring of organ dysfunction are critical components in paediatric sepsis management. The Paediatric Sequential Organ Failure Assessment (pSOFA) score is used to evaluate organ dysfunction and predict the risk of mortality. The aim of the study was to investigate the association between an increase in pSOFA score (∆pSOFA) and mortality among paediatric sepsis patients. This retrospective cohort study included paediatric patients aged 1 month to 18 years diagnosed with sepsis and treated in the PICU from January to December 2023. Receiver Operating Characteristic (ROC) curve analysis was performed to evaluate the predictive value of the pSOFA score for mortality. A total of 87 patients were included in the analysis, with 36 deaths recorded within the first 7 days. Patients with ∆pSOFA ≥1 had a six-fold higher risk of mortality (p<0.001; 95% CI: 3.26–11.02). The day-1 pSOFA score showed poor predictive ability (AUC=0.50), whereas the day-3 score demonstrated good predictive performance (AUC=0.85). An increase in the pSOFA score is significantly associated with a higher risk of mortality in paediatric sepsis patients.
Co-Authors Arlinda Sari Wahyuni Ayodhia Pitaloka Pasaribu Cindy Clarissa Sirait Hendri Wijaya Ika Citra Dewi Tanjung Nadia Setianingsih Rosmayanti Syafriani Siregar Yunnie Trisnawati