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The Impact of Age on Seizure Severity Characteristics in Children With Drug Resistant Epilepsy Tria Diana Lestari; Ika Citra Dewi Tanjung; Syamsidah Lubis; Juliandi Harahap; Johannes Harlan Saing; Wisman Dalimunthe
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.5890

Abstract

Drug-resistant epilepsy (DRE) is found in up to one-third of individuals with epilepsy who have received appropriate therapy and this condition causes significant child morbidity and mortality. Epilepsy that appears at an early age is at higher risk of developing DRE. Objective to assess the effect of age on the characteristics of seizure severity in children with DRE. This study used a cross-sectional design involving 36 DRE patients aged 2-18 years at the Child Neurology Polyclinic, Adam Malik Hospital Medan, from September to October 2024. Seizure severity characteristics were assessed using the Global Assessment of the Severity of Epilepsy (GASE) questionnaire instrument. The categorical data are presented in the form of proportions and the effect of age on seizure severity characteristics was analyzed using the chi-square test. There were 36 children with DRE in this study, predominantly aged ≥ 10 years. Bivariate analysis showed a significant effect of age in children with drug resistant epilepsy only on the disruption of activity experienced by children with a p value = 0.036 (p <0.05). Most patients aged ≥ 10 years did not experience activity disorders or experienced mild activity disorders (73.9%), while in patients aged <10 years, most patients experienced severe activity disorders (61.5%). The age of children with drug resistant epilepsy have a significant effect on daily activity disorders.
Infection Markers as Prediction of Neonatal Sepsis Cindy Clarissa Sirait; Bugis Mardina Lubis; Ika Citra Dewi Tanjung; Hendri Wijaya; Arlinda Sari Wahyuni; Ayodhia Pitaloka Pasaribu
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6066

Abstract

Neonatal sepsis is one of the most common causes of neonatal death in the first month of life. Neonatal sepsis often shows atypical clinical features include temperature instability, lethargy, skin changes, feeding problems, and many others. Isolation of bacteria from the culture is the gold standard for diagnosing sepsis, but this approach is frequently time-consuming and even in cases of negative blood cultures, sepsis cannot be conclusively ruled out, posing a major challenge in its diagnosis and management. Early diagnosis and timely intervention are essential to improve the prognosis of neonatal sepsis. Aim: The aim of this study is to discuss how infection markers can aid in the early identification of neonatal sepsis and what are the best infection markers to predict neonatal sepsis mortality. Method: This study assessed the diagnostic accuracies of infection marker used in the diagnosis of neonatal sepsis. Included studies were retrieved by searching three major databases (Google Scholar, Pubmed, and Science Direct) using MeSH words and relevant references, and reviewed based on the inclusion/exclusion criteria. The article discusses potential advancements and future prospects for biomarkers. An excellent marker can guide antibiotic administration and duration if sepsis is confirmed, reducing unnecessary use. The marker should have high sensitivity, specificity, positive predictive value, negative predictive value and accuracy.
Relationship between Age and the Occurrence of Depression Symptoms in Children with Acute Lymphoblastic Leukemia Dwika Intania Riano; Ika Citra Dewi Tanjung; Ririe Fachrina Malisie; Arlinda Sari Wahyuni; Olga Rasiyanti Siregar; Rini Savitri Daulay
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6230

Abstract

In children and adolescents, depressive symptoms often presenting as irritability, anhedonia, or behavioral changes. Despite significant advancements in survival rates due to improved therapeutic protocols, the psychological burden experienced by children with ALL.Objective: To evaluate the relationship between age and the presence of depressive symptoms in children diagnosed with ALL.Methods: A cross-sectional study was done using consecutive sampling with 40 children aged from 7 to 18 years old acquired, conducted from August to October 2024 at the outpatient unit of Adam Malik Hospital, Medan. Forty children aged 7–18 years with a confirmed diagnosis of ALL were included. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9). Categorical variables were analyzed using the chi-square test, followed by bivariate to identify significant predictors of depression.Results: Among the 40 participants, the most age group were children ≤ 10 years old (65%). A statistically significant association was found between age group and the presence of depressive symptoms (p = 0.001, OR= 33,3). Conclusions: Age is significantly associated with the severity and presence of depressive symptoms in pediatric patients with ALL. Older children were more likely to report higher levels of depression. Psychological evaluation and targeted mental health support may be especially important in older age groups.