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All Journal Jurnal Biomedika dan Kesehatan
Emad Yousif
Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Review: Pengaruh Nanopartikel ZnO sebagai Antimikroba pada Multidrug Resistance Klebsiella Pneumonia Nuha Kudaer; Mohsen Hashim Risan; Emad Yousif; Mohammed Kadhom; Rasha Raheem; Nany Hairunisa; Husnun Amalia
Jurnal Biomedika dan Kesehatan Vol 5 No 3 (2022)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2022.v5.236-242

Abstract

Klebsiella pneumoniae (K. pneumoniae)is a common microorganism for different infections, including respiratory, urinary tract, and biliary diseases, where immunocompromised individuals are directly affected by this bacterium. However, with the emergence of hypervirulent strains, individuals,whether healthy or immunocompetent, are equally susceptible to K. pneumoniae infections. This problem is diagnosed by the wide spreading of multidrug-resistant bacteria in the environment with multiple resistance mechanisms, which are the main challenges for an effective treatment. This put physicians in an inflexible confusion because of the limitation of medical treatment options. Among many remedy substances, zinc oxide (ZnO) nanoparticles (NPs) showed remarkable antibacterial properties versus many Gram-positive and Gram-negative bacteria. This work focuses on presenting the influence of these NPs on the expression of genes in charged in generating the K. pneumoniae capsule. Furthermore, perspectives for applying ZnO NPs in clinical practices are also discussed. As the in vivo studies show a powerful impact of ZnO on bacteria, it is anticipated that this method of treatment will be utilized by hospitals.
Co-Authors Husnun Amalia Mohammed Kadhom Mohsen Hashim Risan Nany Hairunisa Nuha Kudaer Rasha Raheem