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All Journal AL-Daulah International Journal of Cell and Biomedical Science
Amansyah, Fajar
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology

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Hypoxic MSCs Secretome Modulates IL-18-Mediated Inflammatory in Type 2 Diabetes Mellitus via AP-1 Regulation Amansyah, Fajar; Alif, Iffan; Irawan, Risky Candra Satria
International Journal of Cell and Biomedical Science Vol 3 No 7 (2024)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v3i7.47

Abstract

Background: Chronic inflammation is central to the pathophysiology of Type 2 Diabetes Mellitus (T2DM), contributing to the progression of metabolic dysfunction characterized by hyperglycaemia and insulin resistance. This study aims to investigate the therapeutic potential of the hypoxic MSCs secretome (SH-MSCs) in reducing inflammation of a T2DM rat model. Methods: T2DM was induced in Wistar rats through a high-fat diet (HFD) followed by streptozotocin (STZ) administration. A total of 24 healthy male Wistar rats were randomly assigned to five groups: healthy control, T2DM, T2DM + metformin, T2DM + SH-MSCs. Results: SH-MSCs significantly reduced IL-18 mRNA expression, a key indicator of proinflammation, and suppressed the expression of AP-1 mRNA, a crucial proinflammatory transcription factor. Conclusion: These findings highlight the therapeutic potential of SH-MSCs as an alternative approach to alleviate inflammation in T2DM.
Contemporary Challenges and the Future of Islamic Law: Toward Ethical and Institutional Renewal Hammadi, Hammad Farhan; Mohamed Ahmed, Ahmed; Amansyah, Fajar; Rajafi, Ahmad; Taha Alkanan, Omer Mohamed; Jabbar, Israa Natiq
Al-Daulah : Journal of Criminal Law and State Administration Law Vol 14 No 1 (2025): (June)
Publisher : Jurusan Hukum Tatanegara Fakultas Syariah dan Hukum Universitas Islam Negeri Alauddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-daulah.v14i1.58186

Abstract

Research Objective: This study examines internal and external challenges in the Islamic world using Islamic constitutional and criminal law perspectives. It focuses on how principles, particularly those rooted in maqāṣid al-sharīah, can be applied to address legal fragmentation, underdevelopment, Islamophobia, and marginalization. Research Method: A qualitative normative approach was used, supported by thematic and comparative analysis. It draws on primary Islamic texts, constitutions, international legal sources, and academic literature. Case studies from Indonesia and the UAE illustrate different applications of Islamic law in governance and justice. Results: The findings indicate that challenges stem primarily from structural, rather than theological, issues. Internally, these include stagnant education systems, fragmented financial structures, and inconsistent Sharia application. Externally, they involve widespread Islamophobia and limited global representation. Findings and Implications: Islamic legal norms align with democratic values such as equity, participation, and justice. Ethical tenets like maṣlaḥaḥ and shūra support pluralistic governance. Institutional reform and contextual application of Islamic law can improve both domestic legitimacy and international engagement. Conclusion: Islamic legal systems hold the flexibility and strength to meet governance needs. Realizing their potential requires structural reform and aligning jurisprudence with contemporary legal frameworks. Contribution: This study contributes to Islamic legal scholarship by presenting a model that connects classical jurisprudence with modern constitutional practice. It adds to interdisciplinary work, promoting Islamic law in global legal discourse. Limitations and Suggestions: The non-empirical nature and limited jurisdictional scope of the study constrain broader generalization. Future research should incorporate empirical approaches and explore how digital innovation can support Islamic governance reforms.
Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in Ameliorating Renal Fibrosis: A Comprehensive Narrative Review Amansyah, Fajar; Amalina, Nur Dina
International Journal of Cell and Biomedical Science Vol 3 No 8 (2024)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v3i8.55

Abstract

Chronic kidney disease (CKD) represents a global health challenge with limited therapeutic options, often progressing to end-stage renal disease requiring dialysis or transplantation. Renal fibrosis, characterized by excessive extracellular matrix deposition and loss of functional nephrons, constitutes the final common pathway for most progressive kidney diseases. Conventional therapies primarily target symptoms rather than underlying pathological mechanisms. Mesenchymal stem cells (MSCs) have emerged as promising candidates for regenerative therapy due to their multipotent differentiation capabilities, immunomodulatory properties, and paracrine effects. Growing evidence suggests that the therapeutic benefits of MSCs are predominantly mediated through their secretome—a complex mixture of soluble factors, extracellular vesicles, and exosomes. This narrative review comprehensively examines the current understanding of MSC-based therapies for renal fibrosis, with particular emphasis on their secretome. We explore the mechanisms of action, preclinical evidence, ongoing clinical trials, and challenges in translating MSC secretome-based therapies to clinical applications. Recent advances in secretome characterization, bioengineering approaches to enhance therapeutic efficacy, and targeted delivery strategies are also discussed. Despite promising results, several hurdles remain, including standardization of preparation protocols, identification of key therapeutic components, and optimization of delivery methods. This review highlights the transformative potential of MSC secretome in renal fibrosis treatment while acknowledging the need for further research to realize its full clinical potential.
Co-Authors Ahmad Rajafi Alif, Iffan Amalina, Nur Dina Hammadi, Hammad Farhan Irawan, Risky Candra Satria Jabbar, Israa Natiq Mohamed Ahmed, Ahmed Taha Alkanan, Omer Mohamed