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All Journal Journal of Mathematical and Fundamental Sciences International Journal of Electrical, Computer, and Biomedical Engineering (IJECBE)
Nurjamil, Aris Muhammad
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Astronomy Chemistry Computer Science & IT Earth & Planetary Sciences Electrical & Electronics Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics

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Modeling Liver Fibrosis Using hiPSC-Derived Liver Organoids: Methods and Applications Ksatrianto, Faris; Suhantoa, Deviana Lavender; Aziz, Rizal; Natadilandes, Reyhan; Qamarani, audina; Nurjamil, Aris Muhammad; Widowati, Wahyu
International Journal of Electrical, Computer, and Biomedical Engineering Vol. 3 No. 1 (2025)
Publisher : Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62146/ijecbe.v3i1.117

Abstract

Liver fibrosis is a pathological state marked by the excessive buildup of extracellular matrix due to persistent liver damage. Despite the potential of traditional medicines, including antiviral medications and lifestyle adjustments, to decelerate fibrosis progression, a completely effective treatment is still lacking. This article examines the function of human-induced pluripotent stem cells (hiPSCs) in mimicking liver fibrosis. HiPSCs can differentiate into multiple liver cell types, such as hepatocytes, hepatic stellate cells, and endothelial cells, facilitating the reconstruction of liver microarchitecture in both two-dimensional cultures and three-dimensional organoids. These technologies offer critical insights into the pathophysiological underpinnings of the disease, facilitate the discovery of therapeutic targets, and aid in the development of innovative antifibrotic drugs. The use of hiPSCs not only enables novel methods for disease modeling but also presents intriguing opportunities for more targeted and effective regenerative therapy for liver fibrosis.
Mangosteen Peel Extract (Garcinia mangostana L.) as a Potential Complementary of Leukemia Therapy: In Vitro and In Silico Studies Gondokesumo, Marisca Evalina; Novilla, Arina; Prahastuti, Sijani; Zahiroh, Fadhilah Haifa; Kusuma, Hanna Sari Widya; Widowati, Wahyu; Azis, Rizal; Hadiprasetyo, Dhanar Septyawan; Nurjamil, Aris Muhammad; Surakusumah, Wahyu; Adha, Khoerotul Nur Fadhilah
Journal of Mathematical and Fundamental Sciences Vol. 57 No. 2 (2025)
Publisher : Directorate for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2025.57.2.3

Abstract

Leukemia is caused by abnormal white blood cell proliferation that leads to disruption of conventional blood cell functions. Mangosteen (Garcinia mangostana L.) contains phytochemical compounds with strong anticancer properties, according to various cancer studies. This study investigated the potential of mangosteen peel extract (MPE) as an anti-leukemia agent through molecular docking of LC-MS-identified compounds against FLT-1 and AKT proteins, followed by in vitro evaluation on HL-60 cells, namely cytotoxic (WST-8 assay), ROS levels and senescence (flow cytometry), and then FLT1 and AKT gene expression (qRT-PCR). LC-MS identified α-mangostin, β-mangostin, γ-mangostin, mangostinone, and epicatechin as the main compounds. Molecular docking revealed strong binding affinities from −8.5 to −9.9 kcal/mol against AKT, and from −9.0 to −9.9 kcal/mol against FLT-1. MPE (500 µg/mL) decreased cell viability and increased inhibition of HL-60 cells. Intracellular ROS levels decreased significantly at 0.6, 1.2, and 2.4 µg/mL MPE. MPE induced cell senescence especially at 1.2 and 2.4 µg/mL. Gene expression analysis revealed downregulation of AKT at 1.2 and 2.4 µg/mL and FLT1 at 2.4 µg/mL. These findings suggest that MPE may exert multifactorial anti-leukemic mechanisms, including apoptosis, ROS modulation, senescence induction, and regulation of AKT and FLT1 expression.
Co-Authors Adha, Khoerotul Nur Fadhilah Azis, Rizal Hadiprasetyo, Dhanar Septyawan Hanna Sari Widya Kusuma, Hanna Sari Widya Ksatrianto, Faris Marisca Evalina Gondokesumo, Marisca Evalina Natadilandes, Reyhan Novilla, Arina Qamarani, audina Rizal Aziz, Rizal Sijani Prahastuti Suhantoa, Deviana Lavender Wahyu Surakusumah WAHYU WIDOWATI Zahiroh, Fadhilah Haifa