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All Journal JFL : Jurnal Farmasi Lampung Parapemikir Jurnal Ilmiah Farmasi Pharmacon: Jurnal Farmasi Indonesia
Yusuf, Mubarika Sekarsari
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Physics Public Health

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Optimasi Pembuatan dan Karakterisasi Ukuran Partikel Superparamagnetic Iron Oxyde Nanoparticles Wulandari, Anggita Dipika; Yusuf, Mubarika Sekarsari; Husniyah, Laelatul
Parapemikir : Jurnal Ilmiah Farmasi Vol 14, No 2 (2025): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v14i2.8716

Abstract

Superparamagnetic Iron Oxide Nanoparticles (SPION) are iron-based nanoparticles gaining attention in the medical field due to their ability to be magnetically guided and their biocompatibility. This study aimed to explore how different homogenization speeds affect the size, distribution, and stability of SPION synthesized through the co-precipitation method. Three formulations were prepared using homogenization speeds of 1000 rpm, 3000 rpm, and 6000 rpm. The resulting particles were analyzed using Dynamic Light Scattering (DLS) to determine particle size, polydispersity index (PDI), and zeta potential. The results showed that Formula 2 (3000 rpm) produced the smallest and most evenly distributed particles (305,2 nm) with good stability. Formula 3 (6000 rpm) had a higher zeta potential, its particle size was larger and distribution less uniform. Formula 1 (1000 rpm) yielded large but more uniformly distributed particles. The results of this study show moderate homogenization speed offers the best conditions for producing SPION that are small, stable, and suitable for biomedical applications. Formula 2 shows the most promise for future development in drug delivery or magnetic hyperthermia therapies
A COMPARATIVE STUDY OF ANTIBIOTIC KNOWLEDGE BETWEEN PHARMACY STUDENTS AT INSTITUT TEKNOLOGI SUMATERA: A COMPARATIVE STUDY OF ANTIBIOTIC KNOWLEDGE BETWEEN PHARMACY STUDENTS AT INSTITUT TEKNOLOGI SUMATERA Oktariza, Yasinda; Hasanah, Uswatun; Yusuf, Mubarika Sekarsari
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2389

Abstract

Abstract Knowledge about antibiotics is one of the key factors that can increase awareness for the appropriate use of antibiotics. Pharmacy students, as part of health-related academic programs, are expected to take on a role in educating the public about appropriate use of antibiotics. This study aims to assess the level of antibiotic knowledge among second-semester and sixth-semester pharmacy students. The research used an observational design with a cross-sectional approach. The study subjects were pharmacy students from the Faculty of Science at Institut Teknologi Sumatera. The research instrument was a questionnaire that had been tested for validity and reliability, and it was distributed online via Google Forms. A total of 219 respondents participated in this study. Data analysis was conducted by comparing the mean total knowledge scores between the two groups using the Mann-Whitney test. The results showed that sixth-semester students had higher knowledge scores compared to second-semester students. Statistically, a significant difference was found (p < 0.001) between the two groups. These findings indicate that the academic level influences knowledge improvement, as senior students have undergone a longer educational and academic process. Overall, pharmacy students have acquired adequate knowledge regarding the proper use of antibiotics. Keywords:  antibiotic, knowledge, pharmacy, student
A Review of Methodological Standards and Current Practices in Hemolytic Toxicity Testing of Nanoparticle-Based Drug Delivery Systems Yusuf, Mubarika Sekarsari; Nurnahari, Naura
Pharmacon: Jurnal Farmasi Indonesia Volume 22, No 2 (2025)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v22i2.13229

Abstract

Hemolytic toxicity testing is a fundamental component of hemocompatibility assessment for nanoparticle-based drug delivery systems (N-DDSs), as erythrocyte integrity reflects blood safety prior to clinical application. Despite its critical role, experimental procedures vary across the literature. Essential methodological details are frequently omitted, hindering reproducibility and standardization. This variability urges the need for a consolidated reference that examines both current practices and established guidelines. This narrative review aims to provide a structured overview of hemolytic toxicity testing methodologies applied to N-DDSs, with particular emphasis on procedural parameters and their alignment with ASTM and ISO standards. Literature was identified through Google search and open access Scopus-Indexed journals primarily covering publications from 2025 and supplemented with earlier studies to provide historical context. Articles were selected based on relevance to seven methodological parameters which were erythrocyte source, methods of erythrocyte separation and purification, incubation conditions, positive and negative controls, measurement method. Analysis of 30 publications revealed human erythrocytes were the predominant model, with phosphate buffered saline and detergent-like substances were most commonly used negative and positive controls, respectively. Centrifugation controls were inconsistently reported, while incubation was typically run at 37oC, with varying durations depending on the nanoparticle system. Variability was also observed in approaches used to quantify free hemoglobin. Overall, while hemolytic toxicity studies continue to rely on ASTM and ISO guidelines, greater methodological details and standardization would enhance the reliability and reproducibility of hemocompatibility assessments in nanoparticle drug delivery research.
Co-Authors Husniyah, Laelatul Nurnahari, Naura Oktariza, Yasinda Uswatun Hasanah Wulandari, Anggita Dipika