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All Journal Jurnal Riset Ilmu Kesehatan Umum dan Farmasi The Journal General Health and Pharmaceutical Sciences Research IPSSJ
Hengky Ardian
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Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Nursing Public Health Social Sciences Other

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Efektivitas Curcuma Longa sebagai Herbal Preventif dalam Bidang Obstetri-Ginekologi, Pediatri, dan Patologi Anatomi : Kajian Sistematik Fransiska Mochtar; Saddam Muhdi; Hengky Ardian; Siska Silviana
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 2 (2024): April : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v2i2.618

Abstract

Curcuma longa (turmeric) is a widely known herbal plant due to its active compound, curcumin, which possesses anti-inflammatory, antioxidant, and immunomodulatory properties. This review aims to evaluate the preventive effectiveness of Curcuma longa in the fields of obstetrics-gynecology (obgyn), pediatrics, and anatomical pathology. The review was conducted following the PRISMA 2020 guidelines. Literature was searched from PubMed, Scopus, Cochrane Library, and Google Scholar for studies published between 2015 and 2025. Keywords used included: "Curcuma longa", "curcumin", "prevention", "obstetrics", "gynecology", "pediatrics", "anatomic pathology", and "herbal medicine". Articles were selected based on inclusion criteria and evaluated for quality using the JBI Critical Appraisal Tool. Of the 785 articles found, 19 studies met the inclusion criteria. In the obgyn field, curcumin was effective in preventing preeclampsia and endometriosis through modulation of inflammation and angiogenesis. In pediatrics, curcumin showed protective effects against respiratory and gastrointestinal disorders. In anatomical pathology, curcumin was found to inhibit preneoplastic cell transformation and suppress early histopathological changes. Curcuma longa shows great potential as a preventive agent across various medical disciplines. However, further clinical trials with strong study designs are needed to support its application in routine clinical practice
Peran Herbal Medicine dalam Pencegahan Gangguan Neuro-Oftalmologis, Psikiatrik, dan Toksikologi Forensik : Suatu Kajian Sistematik Ardizal Rahman; Hengky Ardian; Agung Wijayanto; Dwi Wijayanti
The Journal General Health and Pharmaceutical Sciences Research Vol. 1 No. 3 (2023): September: The Journal General Health and Pharmaceutical Sciences Research
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/tjghpsr.v1i3.615

Abstract

Neuro-ophthalmological, psychiatric, and toxicological disorders caused by exposure to toxic substances represent a growing global health concern. Preventive approaches using herbal medicine have gained attention due to their relatively favorable safety profiles and broad pharmacological benefits. This study aims to investigate the effectiveness of herbal medicine in preventing disorders across these three domains, based on the latest scientific literature. The review was conducted following the PRISMA 2020 guidelines, with literature searches performed through PubMed, Scopus, and ScienceDirect using keyword combinations such as "herbal medicine," "prevention," "neuro-ophthalmology," "psychiatry," and "toxicology." A total of 27 studies met the inclusion criteria. The findings reveal that certain herbal plants, including Ginkgo biloba, Curcuma longa, and Melissa officinalis, possess neuroprotective, antioxidant, and anxiolytic properties. In conclusion, herbal medicine holds promising potential as part of a preventive strategy against neuro-ophthalmological, psychiatric, and forensic toxicological disorders, although further research is needed to achieve standardization and clinical validation.
EFEK CURCUMA LONGA (KUNYIT) TERHADAP PERUBAHAN HISTOPATOLOGI PADA KARSINOMA KOLOREKTAL: SYSTEMATIC LITERATURE REVIEW Hengky Ardian; Eva Roswati
Integrative Perspectives of Social and Science Journal Vol. 2 No. 03 Agustus (2025): Integrative Perspectives of Social and Science Journal
Publisher : PT Wahana Global Education

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Abstract

Karsinoma kolorektal (KKR) merupakan salah satu penyebab utama mortalitas kanker global. Curcuma longa (kunyit) dan kurkumin memiliki aktivitas anti-inflamasi, antioksidan, dan antikanker, termasuk pengaruh pada perubahan histopatologi tumor. Menilai secara sistematis bukti ilmiah mengenai efek Curcuma longa terhadap perubahan histopatologi pada karsinoma kolorektal. Review ini dilakukan sesuai PRISMA 2020. Pencarian dilakukan pada PubMed, Embase, Scopus, Web of Science, Cochrane, ClinicalTrials.gov, dan Garuda/SINTA hingga Agustus 2025. Artikel inklusi: studi klinis, in vivo, dan in vitro yang mengevaluasi efek kunyit/kurkumin terhadap parameter histopatologi/biomarker jaringan pada kanker kolorektal. Dari 1.243 artikel yang teridentifikasi, 27 memenuhi kriteria. Kurkumin dilaporkan menurunkan indeks proliferasi (Ki-67), meningkatkan apoptosis (TUNEL, caspase-3), serta memperbaiki morfologi histopatologi pada model hewan maupun kultur sel. Beberapa uji klinis menunjukkan manfaat sebagai terapi adjuvan, meskipun hasil masih heterogen. Curcuma longa berpotensi sebagai agen adjuvan untuk kanker kolorektal melalui modifikasi perubahan histopatologi dan biomarker jaringan. Namun, uji klinis berskala besar masih dibutuhkan untuk konfirmasi.
Co-Authors Agung Wijayanto Ardizal Rahman DWI WIJAYANTI Eva Roswati Fransiska Mochtar Saddam Muhdi Siska Silviana