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All Journal Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Allyssia Salma
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Health Professions Nursing Public Health

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Potensi Jintan Hitam (Nigella sativa) sebagai Agen Antibakteri terhadap Bakteri Patogen Klinis Allyssia Salma; Kadeq Novita Prajawanti; Bella Fevi Aristia; Khoirun Nisyak; Widji Soeratri
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.757

Abstract

Antibacterial substances such as thymoquinone, carvacrol, thymol, and p-cymene are found in black cumin (Nigella sativa), a type of herb. This study reviewed 12 recent scientific publications to assess the antibacterial efficacy of N. sativa against clinical pathogenic microorganisms. A comprehensive literature review of in vitro, in silico studies, and applications was conducted. The study found that black cumin extract and oil were more efficient against Gram-positive bacteria such as Staphylococcus aureus than Gram-negative bacteria such as Escherichia coli and Salmonella typhi. The antibacterial activity increased with the concentration of the extract, especially in the polar form (ethanol). Active compounds such as thymoquinone also showed high binding affinity to MRSA bacterial proteins molecularly. The application of N. sativa in the form of ointments, antibacterial textiles, and dental health products also showed good effectiveness. Based on these findings, Nigella sativa has great potential as a safe and environmentally friendly natural antibacterial alternative, although further clinical studies are needed to validate its efficacy and safety.
Review Artikel: Analisis Formulasi dan Evaluasi Tablet Effervescent Dewi Rahmawati; Dzakiya Zhihrotulwida; M. Fithrul Mubarak; Yani Ambari; Allyssia Salma; Siti Nur Rohmania; Siti Khoiriyah; Achmad Saichoni Arthaganda; Winda Wulandari; Salsabila Firdausi Hernila Putri; Silfi Maslicha
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1404

Abstract

The purpose of writing this review article is to analyze the formulation and evaluation of the use of various additives in effervescent tablets. The method used is a literature review taken from journals and other relevant research results regarding the formulation and evaluation of additives in various types of effervescent tablets. The purpose of this analysis is to provide a summary of relevant publications and to improve current understanding in this field. The importance of the formulation and evaluation of additives in effervescent tablets cannot be ignored, because it is a crucial aspect in product development. Decisions in the use of additives must consider the objectives to be achieved, the desired physical characteristics, product stability, and the level of consumer acceptance. With a deep understanding of this formulation and evaluation, we have the potential to produce high-quality effervescent tablets. Variations in additives can also provide different taste and texture characteristics, which of course can affect consumer acceptance.  
Co-Authors Achmad Saichoni Arthaganda Bella Fevi Aristia DEWI RAHMAWATI Dzakiya Zhihrotulwida Kadeq Novita Prajawanti Khoirun Nisyak M. Fithrul Mubarak Salsabila Firdausi Hernila Putri Silfi Maslicha Siti Khoiriyah Siti Nur Rohmania Widji Soeratri Winda Wulandari Yani Ambari