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Artikel Review : Evaluasi pada Sediaan Steril Safanda Tiara Fitri; Maulidiyah Cholifah; Isna Wulan Mukarromah; Renny Angreyni; Ferdiana Putri Gita Veronika; Dewi Rahmawati; Dzakiya Zhihrotulwida; M. Fithrul Mubarak
An-Najat Vol. 3 No. 1 (2025): An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i1.2279

Abstract

Sterile preparations are pharmaceutical products that must be free from microorganisms and foreign particles, so they are very important to use in applications that involve direct contact with human body tissue or the circulatory system. The aim of this research is to understand the evaluations that exist on sterile preparations, as well as understanding all the tests carried out on sterile preparations. The method used is the article review method, which sorts thousands of journals into hundreds, tens and up to 5 journals that match the theme. The results obtained are evaluations in sterile preparations, namely organoleptic tests, pH tests, clarity tests, transferred volume tests, homogeneity tests, spreadability tests, adhesion tests, viscosity tests, etc.
CPOB Sediaan Steril Dewi Rahmawati; Dzakiya Zhihrotulwida; M. Fitrul Mubarak; Ismatun Maulidiyah; Elsa Saqila; Aprilia Puji; Ika Hepi; Silvi Novita Permatasari
Medical Laboratory Journal Vol. 2 No. 4 (2024): December : Medical Laboratory Journal
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/caloryjournal.v2i4.507

Abstract

The importance of Good Manufacturing Practices (GMP) in the pharmaceutical industry to ensure the quality and safety of drug products. GMP aims to ensure that all pharmaceutical preparations, including sterile drugs such as infusions and injections, meet strict quality standards. Sterility testing is an important aspect even though it has limitations, such as long incubation times and low probability of detecting contamination. Therefore, any sterility test results that do not meet the requirements must be further investigated to find the cause, either from laboratory errors or contamination in the production process. In addition, the implementation of technical and managerial aspects in accordance with GMP, such as temperature and humidity control, is very important to maintain product quality. This article also highlights the use of modern technologies, such as Service Oriented Architecture (SOA), to improve efficiency and transparency in the drug production process, so that it can meet all the provisions set.
Review Artikel : Sediaan Steril Injeksi Miya Hartini Nur Wakhid; Fina Nikmatul W; Windi Tri Wahyuni; Rizki Amalia Putri; Dewi Nur Halisa; Magdalena Kasih Belaon Lebuan; Dewi Rahmawati; Dzakiya Zhihrotulwida; M. Fithrul Mubarak
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 1 (2025): Januari : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i1.506

Abstract

Sterile injection preparations are liquid pharmaceutical preparations that are specifically designed to be administered directly into the body through injection using a sterile syringe or clean injection device. The main requirement for sterile injection preparations is that they must be free from microorganisms, foreign particles, and pyrogenic substances that can trigger fever or infection reactions in patients. Testing the quality of sterile injection preparations includes various aspects, ranging from sterility testing, pyrogenicity testing, clarity testing, to stability testing during the shelf life. Stability testing aims to ensure that the preparation remains safe, effective, and stable until its expiration date. The purpose of this study was to determine the evaluation of sterile injection preparations. The method used is by reviewing journals from Google Scholar, Pubmed, etc. from 2018-2024.  
Artikel Riview: Pengaruh Penggunaan Matriks Pada Tablet Lepas Lambat Maulina Apriani; Dian Ayu Oktavia; Isnaini Sukmaning M; Dila Alvia Rahmasari; Zahwa Natasya Novita P; Alvito Syawal Z; Dewi Rahmawati; Dzakiya Zhihrotulwida; Yani Ambari; M. Fithrul Mubarak
Inovasi Kesehatan Global Vol. 2 No. 2 (2025): Mei : Inovasi Kesehatan Global
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/ikg.v2i2.1580

Abstract

Sustained-release tablets are pharmaceutical preparations designed to gradually release the active substance over a specific period, thereby maintaining a constant concentration of the drug in the circulatory system and enhancing therapeutic effectiveness.The development of sustained-release tablets aims to extend the duration of drug action, reduce the frequency of dose administration, and minimize fluctuations in drug levels in the plasma, which ultimately enhances patient compliance and treatment effectiveness, especially in chronic diseases.The purpose of this review is to identify various formulation methods and innovations in the production of sustained-release tablets, as well as to examine the factors that influence the success of these formulations.The method used in this study is a literature review that collects data from various scientific publications over the past five years through online platforms such as Google Scholar, using keywords related to matrix sustained-release tablets and pharmaceutical formulations.The results of the review indicate that various techniques, such as formulating polymer matrices, coating, and encapsulation, have been applied with varying degrees of success depending on the type of active ingredients and excipients used. Some formulation innovations, such as the use of natural polymer matrices and matrix modifications, have proven effective in achieving controlled, stable, and quality-standard-compliant drug release.
Review Artikel: Analisis Formulasi dan Evaluasi Tablet Effervescent Dewi Rahmawati; Dzakiya Zhihrotulwida; M. Fithrul Mubarak; Yani Ambari; Allyssia Salma; Siti Nur Rohmania; Siti Khoiriyah; Achmad Saichoni Arthaganda; Winda Wulandari; Salsabila Firdausi Hernila Putri; Silfi Maslicha
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1404

Abstract

The purpose of writing this review article is to analyze the formulation and evaluation of the use of various additives in effervescent tablets. The method used is a literature review taken from journals and other relevant research results regarding the formulation and evaluation of additives in various types of effervescent tablets. The purpose of this analysis is to provide a summary of relevant publications and to improve current understanding in this field. The importance of the formulation and evaluation of additives in effervescent tablets cannot be ignored, because it is a crucial aspect in product development. Decisions in the use of additives must consider the objectives to be achieved, the desired physical characteristics, product stability, and the level of consumer acceptance. With a deep understanding of this formulation and evaluation, we have the potential to produce high-quality effervescent tablets. Variations in additives can also provide different taste and texture characteristics, which of course can affect consumer acceptance.  
Formulasi Dan Evaluasi Tablet Hisap Dari Ekstrak Tanaman: Review Artikel Lailita Rani, Andini; Wulan Novita Dewi; Nadiya Difilla Salim; Siti Yunita Octaviani; Fiky Aldhi; Shawa Satria Parnaen; Jubri Yanto; Dewi Rahmawati; Dzakiya Zhihrotulwida
Sains Medisina Vol 3 No 5 (2025): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/snsmed.v3i5.703

Abstract

Dalam bentuk sediaan padat, tablet hisap didesain untuk terdegradasi secara perlahan di mulut sehingga mampu memberikan efek terapi secara lokal maupun sistemik. Keistimewaannya mencakup ketepatan takaran, kepraktisan penggunaan, serta absorpsi yang lebih cepat dibandingkan bentuk sediaan lain. Studi ini ditujukan untuk mengkaji komposisi dan penilaian sediaan tablet hisap yang menggunakan ekstrak tumbuhan sebagai bahan aktif. Metode yang dilakukan adalah literature review article (LRA) terhadap jurnal-jurnal terkait selama dekade terakhir, hasil kajian literatur mengungkapkan bahwa formulasi tablet hisap sangat bergantung pada pemilihan bahan aktif, bahan tambahan (pemanis, bahan pengikat), dengan metode pembuatan (granulasi basah atau kempa langsung). Bahan pengikat seperti CMC-Na, gelatin, dan PVP berperan dalam menentukan kekerasan, kerapuhan, dan waktu hancur tablet, sementara pemanis seperti sukrosa, manitol, dan xylitol memengaruhi stabilitas dan rasa. Ekstrak tanaman yang telah dilakukan penelitian terbukti efektif diformulasikan menjadi tablet hisap dengan manfaat farmakologis. Evaluasi organoleptik menunjukkan bahwa formulasi harus memenuhi standar kerapuhan, waktu hancur, keseragaman bobot, dan kekerasan. Kesimpulan tablet hisap berbahan ekstrak tanaman dapat menjadi sediaan tablet hisap yang aman dan diterima pasien, terutama untuk kelompok pediatri dan geriatri.
Efektivitas Dan Proses Sterilisasi Uap Dalam Farmasi Niken Rahmita; Dewi Rahmawati; Sirojul Eilma; Sari Fatul Layly; Anisya Khusnul; Dzakiya Zhihrotulwida; M. Fitrul Mubarak
Jurnal Ilmu Psikologi dan Kesehatan | E-ISSN : 3063-1467 Vol. 1 No. 4 (2025): Januari - Maret
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Sterilization is the liberation of materials or tools from various living microorganisms or their resting stages. Sterilization methods can be divided into two general groups, namely physical and chemical. Although sterilization can be achieved with certain chemicals, generally physical methods are more reliable. One of the most effective methods for killing microorganisms is using high temperatures. One of the sterilizers that uses the pressurized steam heat method is the autoclave. This review article was carried out with the aim of discussing and providing information to readers regarding the sterilization of tools and materials that will be used in medical and non-medical settings, which is very important in every manufacturing process. Apart from that, we also know the benefits and processes of sterilization that are commonly used, namely steam sterilization.