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All Journal Chemistry Indonesian Journal of Chemical Research ARTERI : Jurnal Ilmu Kesehatan
Riska, Bella
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Biochemistry, Genetics & Molecular Biology Chemistry Electrical & Electronics Engineering Engineering Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

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Uji Antioksidan dan Toksisitas Ekstrak Batang Polygonum Minus Huds Ginjal Tikus Wistar Sukandiarsyah, Fadli; Ropiqa, Meri; Riska, Bella
ARTERI : Jurnal Ilmu Kesehatan Vol 6 No 2 (2025): Februari
Publisher : Puslitbang Sinergis Asa Professional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/arteri.v6i2.500

Abstract

Kesum plants have demonstrated robust antioxidant activity and possess the potential to function as antiviral, antibacterial, antifungal, anticancer, and antiulcer agents. Further research is necessary to investigate the activity and toxicity of kesum stem preparations. The objective of this study is twofold: first, to ascertain the antioxidant activity of an ethanol extract of kesum stem; and second, to determine the level of acute toxicity in the kidneys of Wistar rats. The extraction process was conducted using the maceration method, employing 70% ethanol as the solvent. The antioxidant activity test demonstrated that the ethanol extract of kesum stem exhibited an IC50 value of 72.03 ppm, thereby classifying it as a strong antioxidant. The acute toxicity test demonstrated that the ethanol extract of kesum stem (Phyllanthus emblica) at doses of 500 mg/kg, 1000 mg/kg, and 2000 mg/kg did not induce toxic effects on the kidneys. This finding was substantiated by the observation that the levels of ureum and creatinine remained within the normal range. The findings of this study, derived from statistical analysis employing the analysis of variance (ANOVA) method, indicated a p-value of 0.632 (p > 0.05) for serum urea examination and 0.06 (p > 0.05) for serum creatinine examination. These findings suggest that there is no statistically significant difference between the treatment groups. The safety of all three doses has been demonstrated by the absence of toxicity effects on rat kidney organs.
Antioxidant and Anti-inflammatory Activity of Ethanol Extracts from Sambal Orange Peel (Citrus microcarpa Bunge) on Erythrocyte Membrane Stabilization Sukandiarsyah, Fadli; Hayati, Defi Nurul; Sari, Vina Purnama; Riska, Bella
Indonesian Journal of Chemical Research Vol 13 No 2 (2025): Edition for September 2025
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2025.13-fad

Abstract

Inflammation is the body's defense response to various stimuli. Sambal orange (Citrus microcarpa Bunge) belongs to the Rutaceae family and is widely cultivated in West Kalimantan. This study uses the erythrocyte membrane stabilization method to test the secondary metabolite content, antioxidant activity, and anti-inflammatory activity of ethanol extracts of sambal orange peel. Antioxidant activity was assessed using the DPPH method, while anti-inflammatory activity was evaluated through erythrocyte membrane stabilization. The results showed that the extract had an antioxidant IC50 value of 17.90 ppm, which is very strong. Membrane stability at concentrations of 50, 100, 150, 200, and 250 ppm showed increases of 32.20%, 38.39%, 47.37%, 55.18%, and 65.52%, respectively. The % stability values of sodium diclofenac at the same concentrations were 50.10%, 58.40%, 66.69%, 78.59%, and 87.70%, respectively. The one-way ANOVA test showed a significance value of 0.000 (p < 0.05), indicating a significant difference between treatments. The Tukey post-hoc test showed no significant difference between the 250 ppm extract concentration and the 150 ppm sodium diclofenac concentration. The IC50 value for the extract's anti-inflammatory activity was 163.55 ppm (moderate activity), while sodium diclofenac exhibited stronger activity with an IC50 value of 54.09 ppm.
Co-Authors Hayati, Defi Nurul Ropiqa, Meri Sukandiarsyah, Fadli Vina Purnama Sari