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All Journal MPI (Media Pharmaceutica Indonesiana) GUYUB: Journal of Community Engagement Folia Medica Indonesiana
Marzuki, Jefman Efendi
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Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Social Sciences Other

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Efek Samping Agranulositosis Imbas Metamizole: Kajian Pustaka Pribadi, Ezra Immanuelly; Marzuki, Jefman Efendi; Herawati, Fauna
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 1 (2025): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i1.7300

Abstract

Agranulositosis merupakan kondisi yang jarang terjadi, namun dapat berpotensi fatal dan menyebabkan kematian apabila tidak ditindaklanjuti secara tepat dan cepat. Insidensi agranulositosis yaitu 6,2 juta kasus/penduduk/tahun. Agranulositosis imbas obat dapat disebabkan oleh analgesik antipiretik metamizole, dimana aksesibilitas metamizole mudah di Indonesia. Tujuan penulisan artikel ini adalah untuk memaparkan kejadian agranulositosis imbas metamizole. Tinjauan pustaka dilakukan dengan pencarian artikel melalui basis data Pubmed dan Google Scholar. Berdasarkan eksplorasi literatur, beberapa faktor risiko yang mempengaruhi kejadian agranulositosis adalah jenis kelamin, usia lanjut, infeksi virus dan durasi penggunaan yang lebih lama. Oleh karena itu, diperlukan pertimbangan mengenai manfaat dan risiko penggunaan metamizole. Agranulocytosis is a rare but potentially fatal condition that can lead to death if not promptly and appropriately managed. The incidence of agranulocytosis is estimated at 6.2 cases per million population per year. Drug-induced agranulocytosis can be triggered by the use of the analgesic and antipyretic agent metamizole, which remains widely accessible in Indonesia. This article aims to present findings related to agranulocytosis induced by metamizole. This literature review was conducted through article searches in the PubMed and Google Scholar databases. Based on the reviewed literature, several risk factors influencing the occurrence of agranulocytosis include female gender, older age, viral infections, and prolonged duration of metamizole use. Therefore, careful consideration of the benefits and risks of metamizole use is essential in clinical practice. Submitted: 24-01-2025, Revised: 19-05-2025, Accepted: 26-05-2025, Published regularly: June 2025
The Tubarial Glands: Key Anatomical Features and Clinical Significance Nur Aditya, Dwi Martha; Santosa, Winnie Nirmala; Marzuki, Jefman Efendi; Sukarno, Devitya Angielevi; Baharuddin, Baharuddin; Prawitasari, Dita Sukmaya; Sajuni, Sajuni; Setyo Wicaksono, Adhimas; Djuanda, Stephanie Natasha
Folia Medica Indonesiana Vol. 60, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

Medical technological advancements have revealed previously unknown anatomical features in the nasal cavity known as tubarial glands. However, many questions remain unanswered concerning these glands. Through this systematic review, we sought to analyze the tubarial glands, including their major discovery, anatomical and histological features, and clinical significance. Articles were identified according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, with data collected from Scopus, ScienceDirect, SpringerLink, and PubMed until September 2024. Medical Subject Headings (MeSH) were utilized with various terminology: "tubarial gland*", "tubarial salivary gland*", and "radiotherapy”. The inclusion criteria were: (1) resources categorized as original research reports, case reports, case studies, letters to the editor, brief communications, commentaries, editorials, and news; (2) publications with accessible full text; and (3) articles providing information on the tubarial glands. The exclusion criteria were: (1) papers categorized as systematic reviews, meta-analyses, or bibliometric analyses; and (2) articles not published in English. The identification yielded 37 resources from around the world, including 19 original research reports (51.3%), 3 case reports (8.1%), 6 letters to the editor (16.2%), 2 brief communications (5.4%), 7 commentaries (18.9%), 1 editorial (2.7%), and 1 news article (2.7%). The research subjects comprised 1 healthy patient (2.7%) out of 26 subjects, 12 prostate cancer patients (32.4%) out of 612 subjects, 3 head and neck cancer patients (8.1%) out of 38 subjects, 1 nasopharyngeal carcinoma patient (2.7%) out of 240 subjects, 1 Sjögren's syndrome patient (2.7%) out of 29 subjects, 1 patient with oncocytic papillary cystadenoma (2.7%), and 20 patients with other conditions (54.0%). This systematic review suggests that the newly discovered glands exhibit similar morphological, histological, and physiological properties to salivary glands and may have a function in the lubrication and maintenance of the upper airway.
Innovation of Cilembu Sweet Potato-Based Chicken Nuggets as an Effort to Prevent Stunting Kirtishanti, Aguslina; Trisnawati, Chatarina Yayuk; Irawati, Sylvi; Marzuki, Jefman Efendi
GUYUB: Journal of Community Engagement Vol 6, No 4 (2025): Desember
Publisher : Universitas Nurul Jadid

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33650/guyub.v6i4.12567

Abstract

Stunting remains an important health issue in Duyung Village, Trawas Subdistrict, Mojokerto Regency. Cilembu sweet potatoes, which are nutrient-dense and widely available in the village, currently have low economic value. Processing these sweet potatoes into food products can enhance nutrient value, support stunting prevention, and improve their economic worth. To effectively and healthily utilize the local potential of Cilembu sweet potatoes, a training activity focused on preparing Cilembu-based chicken nuggets was conducted using the Participatory Action Research (PAR) method, which encompasses problem and needs identification, action planning, implementation, and reflection and sustainability. Fourteen participants were involved in the activity. The median score for perceived knowledge and skills in making Cilembu sweet potato-based chicken nuggets increased significantly after training compared with before training (3.0 vs 1.5, p = 0.006; 3.0 vs 1.0, p = 0.002). As many as 92.9% of participants reported the activity was beneficial and satisfying. Continuous monitoring and evaluation are necessary to ensure the continued production of Cilembu sweet potato-based chicken nuggets and to assess their long-term effects on the village community's economy and health
Co-Authors Aguslina Kirtishanti Baharuddin Baharuddin Djuanda, Stephanie Natasha Herawati, Fauna Nur Aditya, Dwi Martha Prawitasari, Dita Sukmaya Pribadi, Ezra Immanuelly Sajuni Sajuni Santosa, Winnie Nirmala Setyo Wicaksono, Adhimas Sukarno, Devitya Angielevi Sylvi Irawati Trisnawati, Chatarina Yayuk