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All Journal Majalah Patologi Indonesia Folia Medica Indonesiana
Djuanda, Stephanie Natasha
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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PROFIL KLINIKOPATOLOGI KARSINOMA LARING DI RSUD DR SOETOMO, SURABAYA 2018-2021 Djuanda, Stephanie Natasha; Kusumastuti, Etty Hary; Ariani, Grace
Majalah Patologi Indonesia Vol. 34 No. 1, Januari 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i1.614

Abstract

Introduction Laryngeal carcinoma is the second most common malignancy of the respiratory tract1. Based on 2020 Global Cancer Observatory data, the incidence rate of laryngeal carcinoma is 184,615 cases with a mortality rate > 50%2. There are some prognostic factors that predict the prognosis and 5 year survival rate of the patients. Study of this factor is very important because it will affect the patient's management 1,3.The clinicopathological profile is very important in laryngeal carcinoma because the majority of specimen are received in the small biopsies. Methods This research is observational descriptive study with a retrospective approach. Population of this study are paraffin blocks obtained from biopsy and surgical that had been diagnosed histopathologically as laryngeal carcinoma in the Dr. Soetomo General Academic Hospital from January 2018 - December 2021. Demographic, radiologic and histopathology data were taken from the patient's medical records. Results The majority patients were males (93%). The average age of patients was 59 (±5.91) years, with age range is 27 – 84 years, peak incidence were in 61-70 years (34.1%). The tumor located mostly in glottic (60.2%). Based on the T and N staging, most patient came at T4 and N2 stage. All the tumor were conventional squamous cell carcinoma. Conclusion Clinicopathology profile is very important in determine the prognostic factor in laryngeal carcinoma. Most of patient were males, in age group 61-70 years, located in glottis. Most patient came at advanced stadium. Most tumor were conventional squamous cell carcinoma, and the majority was well differentiated grade.  
The Tubarial Glands: Key Anatomical Features and Clinical Significance Nur Aditya, Dwi Martha; Santosa, Winnie Nirmala; Marzuki, Jefman Efendi; Sukarno, Devitya Angielevi; Baharuddin, Baharuddin; Prawitasari, Dita Sukmaya; Sajuni, Sajuni; Setyo Wicaksono, Adhimas; Djuanda, Stephanie Natasha
Folia Medica Indonesiana Vol. 60, No. 4
Publisher : Folia Medica Indonesiana

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Medical technological advancements have revealed previously unknown anatomical features in the nasal cavity known as tubarial glands. However, many questions remain unanswered concerning these glands. Through this systematic review, we sought to analyze the tubarial glands, including their major discovery, anatomical and histological features, and clinical significance. Articles were identified according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, with data collected from Scopus, ScienceDirect, SpringerLink, and PubMed until September 2024. Medical Subject Headings (MeSH) were utilized with various terminology: "tubarial gland*", "tubarial salivary gland*", and "radiotherapy”. The inclusion criteria were: (1) resources categorized as original research reports, case reports, case studies, letters to the editor, brief communications, commentaries, editorials, and news; (2) publications with accessible full text; and (3) articles providing information on the tubarial glands. The exclusion criteria were: (1) papers categorized as systematic reviews, meta-analyses, or bibliometric analyses; and (2) articles not published in English. The identification yielded 37 resources from around the world, including 19 original research reports (51.3%), 3 case reports (8.1%), 6 letters to the editor (16.2%), 2 brief communications (5.4%), 7 commentaries (18.9%), 1 editorial (2.7%), and 1 news article (2.7%). The research subjects comprised 1 healthy patient (2.7%) out of 26 subjects, 12 prostate cancer patients (32.4%) out of 612 subjects, 3 head and neck cancer patients (8.1%) out of 38 subjects, 1 nasopharyngeal carcinoma patient (2.7%) out of 240 subjects, 1 Sjögren's syndrome patient (2.7%) out of 29 subjects, 1 patient with oncocytic papillary cystadenoma (2.7%), and 20 patients with other conditions (54.0%). This systematic review suggests that the newly discovered glands exhibit similar morphological, histological, and physiological properties to salivary glands and may have a function in the lubrication and maintenance of the upper airway.
Co-Authors Ariani, Grace Baharuddin Baharuddin KUSUMASTUTI, ETTY HARY Marzuki, Jefman Efendi Nur Aditya, Dwi Martha Prawitasari, Dita Sukmaya Sajuni Sajuni Santosa, Winnie Nirmala Setyo Wicaksono, Adhimas Sukarno, Devitya Angielevi