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All Journal The Journal of Pure and Applied Chemistry Research
Mega Nurul Madania
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Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

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The Effect of Surfactant on the Characteristics of Curcumin-Loaded Nanostructured Lipid Carriers: Fluorescence and Stability Study Mega Nurul Madania; Zubaidah Ningsih; Anastasia Fitria Devi; Diah Mardiana; Ulfa Andayani
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 1 (2025): Edition January-April 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2025.014.01.7933

Abstract

Curcumin, a bioactive compound derived from Curcuma longa, offers significant pharmacological benefits such as antioxidant, anti-inflammatory, and anticancer properties. However, its therapeutic application is restricted due to poor water solubility, low systemic bioavailability, and limited skin penetration. This study explores the use of Nanostructured Lipid Carriers (NLCs) as a drug delivery system to improve curcumin's stability and permeability. Two formulations were developed: NLC-KUR-T80, which encapsulates curcumin using the non-ionic surfactant Tween 80, and NLC-KUR-CTAB, which uses the cationic surfactant CTAB. Both formulations were prepared using the Phase Inversion Temperature (PIT) method and characterized for particle size, polydispersity index (PI), zeta potential, encapsulation efficiency (EE%), and fluorescence properties. Results revealed that CUR-NLC-CTAB exhibited a larger particle size (1410 ± 183 nm), higher zeta potential (78.70 ± 0.67 mV), and significantly better encapsulation efficiency (27.33 ± 3.33%) compared to CUR-NLC-T80. Fluorescence studies demonstrated that curcumin within NLC-CTAB had enhanced fluorescence intensity, indicating better stability and distribution within the lipid matrix.
Co-Authors Anastasia Fitria Devi Diah Mardiana Ulfa Andayani Zubaidah Ningsih