Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal The Journal of Pure and Applied Chemistry Research
Zubaidah Ningsih
Unknown Affiliation
Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
The Effect of Surfactant on the Characteristics of Curcumin-Loaded Nanostructured Lipid Carriers: Fluorescence and Stability Study Mega Nurul Madania; Zubaidah Ningsih; Anastasia Fitria Devi; Diah Mardiana; Ulfa Andayani
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 1 (2025): Edition January-April 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2025.014.01.7933

Abstract

Curcumin, a bioactive compound derived from Curcuma longa, offers significant pharmacological benefits such as antioxidant, anti-inflammatory, and anticancer properties. However, its therapeutic application is restricted due to poor water solubility, low systemic bioavailability, and limited skin penetration. This study explores the use of Nanostructured Lipid Carriers (NLCs) as a drug delivery system to improve curcumin's stability and permeability. Two formulations were developed: NLC-KUR-T80, which encapsulates curcumin using the non-ionic surfactant Tween 80, and NLC-KUR-CTAB, which uses the cationic surfactant CTAB. Both formulations were prepared using the Phase Inversion Temperature (PIT) method and characterized for particle size, polydispersity index (PI), zeta potential, encapsulation efficiency (EE%), and fluorescence properties. Results revealed that CUR-NLC-CTAB exhibited a larger particle size (1410 ± 183 nm), higher zeta potential (78.70 ± 0.67 mV), and significantly better encapsulation efficiency (27.33 ± 3.33%) compared to CUR-NLC-T80. Fluorescence studies demonstrated that curcumin within NLC-CTAB had enhanced fluorescence intensity, indicating better stability and distribution within the lipid matrix.
Characterization of Ca-Alginate-Gelatin Waste Beads Salistya, Sarahita Dinda; Ellya Indahyanti; Diah Mardiana; Zubaidah Ningsih
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 2 (2025): Edition May-August 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

The rapid growth of industry in Indonesia is partly driven by the emergence of new sectors such as the pharmaceutical industry. This sector has experienced a surge in the production of various types of medical capsules, with shells made from gelatin, colorants, and other components. As capsule production increases, so does the amount of gelatin waste was generated. In this study, beads were manufactured using an extrusion technique with 0.1 M CaCl2 to induce cross-linking. The ratio of alginate to gelatin waste was varied to determine the stability of the beads. The stability of the beads was observed over seven days, and the optimal composition was found to be 1:1. From the results of the TGA/DTA characterization, thermal analysis revealed that the combination of gelatin waste and sodium alginate improved its material properties. SEM results show that the Ca-Alginate-Gelatin waste beads contained alginate network, resulting in a porous structure and amorphous shape. Based on these finding, the beads produced have the potential to serve as adsorbents for use in slowed release fertilizers.
Co-Authors Anastasia Fitria Devi Diah Mardiana Ellya Indahyanti Mega Nurul Madania Salistya, Sarahita Dinda Ulfa Andayani