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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan MEDIC MEdical Dedication
Tarigan, Nadir Putra Indra
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Health Professions Medicine & Pharmacology Nursing Physics Public Health

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Exploration The Multifaceted Role Of Vitamins In Epigenetic Regulation: Insights Into DNA Methylation And Histone Modification Perkasa, Tengku Arief Buana; Puspasari, Anggelia; Priskila, Loury; Tarigan, Nadir Putra Indra; Widyawati, Dwi; Neldi, Vina
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 13 No. 1 (2025): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v13i1.42536

Abstract

Background: Recent research shows that vitamins actively regulate epigenetic mechanisms like DNA methylation and histone changes. Gene regulation, cellular differentiation, and disease development depend on these pathways. Aims: This review aims to synthesize current evidence on how vitamins A, B, C, D, E, and K influence epigenetic regulation, and to elucidate their potential roles in health maintenance and disease prevention. Methods: NCBI and ScienceDirect were used to search English-language literature from 2015 to 2024 for a narrative review. To capture vitamins' direct and indirect impacts on epigenetic pathways, selected peer-reviewed papers were qualitatively examined. Results: Vitamin A affects gene expression via receptor-mediated mechanisms which modify chromatin structure. B vitamins provide methyl donors for DNA methylation and histone changes. Vitamin C cofactors TET enzymes and histone demethylases, supporting active DNA demethylation and histone acetylation. The vitamin D receptor (VDR) affects DNA methyltransferases and histone-modifying enzymes, regulating gene transcription. Vitamins E and K modulate oxidative stress and histone changes to stabilize the epigenome, which may benefit cancer treatment and metabolic regulation. Conclusion: Vitamins' diverse and linked epigenetic regulatory activities are highlighted.  These micronutrients may help prevent and treat cancer, metabolic problems, and developmental anomalies by maintaining genomic integrity and influencing gene expression. Keywords: Vitamins, Epigenetics, DNA Methylation, Histone Modification, Nutritional Epigenetics, Gene Expression.
DEVELOPMENT AND DISSEMINATION OF A SOCIAL MEDIA-BASED E-LEAFLET FOR PREOPERATIVE PATIENT EDUCATION ON THE PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING Kemal, Naufal Athar Faiq; Astuti, Widuri; Perkasa, Tengku Arief Buana; Sulistyowati; Istarini, Attiya; Ayudia, Esa Indah; Tarigan, Nadir Putra Indra
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 9 No. 1 (2026): MEDIC. Medical dedication
Publisher : Universitas Jambi

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Abstract

Postoperative nausea and vomiting (PONV) is a frequent complication of general anaesthesia that prolongs recovery, increases the burden of care, and may lead to wound strain, dehydration, and aspiration. Many patients are unaware of this risk and hesitate to report their symptoms, while accessible, evidence-based educational material for the lay public remains scarce. This community service activity aimed to develop an electronic educational leaflet (e-leaflet) on the prevention of postoperative nausea and vomiting and to disseminate it through social media. The activity was carried out in four stages: identifying the educational need, designing the content in a question-and-answer format, developing the material from a scientific literature review followed by expert validation and a lay-readability check, and disseminating the final product through Instagram and TikTok. The resulting product was an eleven-slide visual e-leaflet covering the definition, mechanism, risk factors, consequences, medical prevention, patient preparation, and warning signs of postoperative nausea and vomiting. Expert validation confirmed the scientific accuracy of the content, and lay readers judged the language to be understandable. This activity demonstrates that guideline-based knowledge on PONV can be feasibly translated into an accessible, low-cost digital education product for prospective surgical patients, and lays the groundwork for a subsequent, more rigorous evaluation of its impact on patient knowledge.
Co-Authors Anggelia Puspasari Astuti, Widuri ATTIYA ISTARINI Esa Indah Ayu, Esa Indah Kemal, Naufal Athar Faiq Neldi, Vina Priskila, Loury Sulistyowati Tengku Arief Buana Perkasa Widyawati, Dwi