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Kajian Manfaat Diet Mediterania: Analisis Loury Priskila; Tengku Arief Buana Perkasa; Yogik Onky Silvana Wijaya
Cermin Dunia Kedokteran Vol 51 No 11 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i11.1265

The rapid growth of nutrigenomics and nutrigenetics has greatly contributed to understanding the importance of genetic, nutrition, and environmental interaction in maintaining human health. Healthy lifestyles such as adequate physical activity and healthy diet patterns have been widely reported may reduce the risk of various diseases. One of the health diet patterns that has been widely studied is the Mediterranean diet (MedDiet). MedDiet is a plant-based diet pattern high in fiber, high in unsaturated fatty acids, and low in meat and dairy products. This literature study aims to summarize the health benefits of the MedDiet pattern and its biomechanisms.

The Genetic Variation of Ace Gene Rs4343 Has Lack Association With Pre-Eclampsia: Case-Control Study In Jambi Malay Population Puspasari, Anggelia; Herlambang, Herlambang; Maharani, Citra; Perkasa, Tengku Arief Buana; Enis, Rina Nofri; Tarawifa, Susan; Syukur, Astian Nathaniel
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 13 No. 1 (2025): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v13i1.41334

Background: The PE is leading cause of maternal and neonatal mortality and morbidity worldwide. The etiology of PE remains not yet clearly identified, genetics contributed 20-40% of PE. The variation of the rs4343 gene was significant as a risk factor for PE and the severity of PE with effect sizes varying between studies. To the best of our knowledge, the association of rs4343 in the ACE gene for PE risk has not been reported to the population of Indonesia, especially the Jambi Malays. Aims: This study aims to reveal the association of Genetic Variation of ACE gene rs4343 with preeclampsia. Methods: This recent study was case-control, 78 pregnant women matching based on age and pregnancy number participated in this study. The preeclampsia diagnosis is based on the criteria of the American College of Obstetricians and Gynecologists. The genotyping method was tetra ARMS-PCR. Bivariate statistical analysis was performed. Results: The proportion of the AA genotype and AG genotype was slightly different between the two groups, but all GG genotypes suffered preeclampsia. The recessive model reported the GG/AG genotype has a higher risk of PE than the AA genotype (p-value 0.784; OR 1.16, 95% CI (0.40-3.41)). The allele model reported that the G allele (p-value 0.338; OR 1.59, 95% CI (0.62-4.14)) had a higher risk than the A allele. However, all those differences do not reach statistically significant. Conclusion: Genetic Variation of ACE gene rs4343 Has Lack Association with Pre-eclampsia.

Exploration The Multifaceted Role Of Vitamins In Epigenetic Regulation: Insights Into DNA Methylation And Histone Modification Perkasa, Tengku Arief Buana; Puspasari, Anggelia; Priskila, Loury; Tarigan, Nadir Putra Indra; Widyawati, Dwi; Neldi, Vina
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 13 No. 1 (2025): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v13i1.42536

Background: Recent research shows that vitamins actively regulate epigenetic mechanisms like DNA methylation and histone changes. Gene regulation, cellular differentiation, and disease development depend on these pathways. Aims: This review aims to synthesize current evidence on how vitamins A, B, C, D, E, and K influence epigenetic regulation, and to elucidate their potential roles in health maintenance and disease prevention. Methods: NCBI and ScienceDirect were used to search English-language literature from 2015 to 2024 for a narrative review. To capture vitamins' direct and indirect impacts on epigenetic pathways, selected peer-reviewed papers were qualitatively examined. Results: Vitamin A affects gene expression via receptor-mediated mechanisms which modify chromatin structure. B vitamins provide methyl donors for DNA methylation and histone changes. Vitamin C cofactors TET enzymes and histone demethylases, supporting active DNA demethylation and histone acetylation. The vitamin D receptor (VDR) affects DNA methyltransferases and histone-modifying enzymes, regulating gene transcription. Vitamins E and K modulate oxidative stress and histone changes to stabilize the epigenome, which may benefit cancer treatment and metabolic regulation. Conclusion: Vitamins' diverse and linked epigenetic regulatory activities are highlighted. These micronutrients may help prevent and treat cancer, metabolic problems, and developmental anomalies by maintaining genomic integrity and influencing gene expression. Keywords: Vitamins, Epigenetics, DNA Methylation, Histone Modification, Nutritional Epigenetics, Gene Expression.

A Comparison Between The 5:2 And 16:8 Intermittent Fasting Methods on Weight Loss in Overweight And Obese Individuals Ayudia, Esa Indah; Calista, Amanda Athiyyah; Enis, Rina Nofri; Perkasa, Tengku Arief Buana; Anggraini, Bayu; Asyhar, Rayandra
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 13 No. 1 (2025): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v13i1.43577

ABSTRACT Background: Overweight and obesity are conditions characterized by excess body weight, which increase the risk of chronic diseases. One of the main contributing factors is dietary habits. A popular intervention for weight loss is the Intermittent Fasting (IF) diet, particularly the 5:2 and 16:8 methods. This study aims to compare the effectiveness of the 5:2 and 16:8 IF methods in reducing body weight among overweight and obese individuals. Methods: This research employed a pre and post test design involving 50 respondents, divided into two groups, and subjected to a 6-week intervention. Data were analyzed using the Paired Sample T-Test (for IF 5:2), the Wilcoxon Test (for IF 16:8), and the Mann-Whitney Test for comparison between the two groups. Results: The results showed that the IF 5:2 group experienced an average weight loss of 3.38% (p < 0.001), while the IF 16:8 group had a weight loss of 2.28% (p = 0.000). The comparison between the two groups yielded a p-value of 0.081. Conclusion: Both IF methods, 5:2 and 16:8, are effective in significantly reducing body weight. Although the 5:2 method resulted in a greater weight loss, the difference between the two methods was not statistically significant.

OPTIMIZING MATERNAL AND CHILD HEALTH: ENHANCING PUBLIC AWARENESS OF TORCH INFECTIONS DURING PREGNANCY Ekaputri, Tia Wida; Enis, Rina Nofri; Tarawifa, Susan; Harahap, Huntari; Syauqy, Ahmad; Perkasa, Tengku Arief Buana
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 8 No. 1 (2025): MEDIC. Medical dedication
Publisher : Universitas Jambi

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TORCH infections (Toxoplasmosis, Rubella, Cytomegalovirus, Herpes simplex) pose significant risks during pregnancy, contributing to congenital abnormalities and adverse neonatal outcomes. In Indonesia, limited public awareness and inadequate preventive practices exacerbate these risks. This community service initiative aimed to enhance knowledge about TORCH infections among reproductive-aged women through a hybrid educational seminar. Conducted in collaboration with Peduli TORCH, the program utilized the "5P Framework" (Pathogen Awareness, Prenatal Screening, Pathogen Management, Postnatal Monitoring, Preventive Practices) to deliver evidence-based strategies. A total of 54 participants (87% female, 61.1% from Jambi Province) attended the seminar, combining in-person and virtual engagement. Pre- and post-tests assessed knowledge improvement, revealing a statistically significant median score increase from 70.0 to 100.0 (p<0.001, Wilcoxon test). Participants reported high satisfaction with the seminar’s content, interactive format, and accessibility, though logistical refinements were suggested for future iterations. The initiative successfully bridged knowledge gaps, emphasizing the importance of early screening, vaccination, and hygiene practices. By empowering women and leveraging community engagement, this program highlights the potential of targeted educational interventions to reduce TORCH-related morbidity and improve maternal-child health outcomes. Culturally adapted, hybrid approaches demonstrate promise for scalable public health strategies in low-resource settings.

STRATEGI INOVATIF PENINGKATAN KESADARAN TENTANG DIABETES MELITUS: MENGURANGI RISIKO MELALUI EDUKASI DAN SCREENING DI MASYARAKAT Ayudia, Esa Indah; Amatullah, Afifah; Perkasa, Tengku Arief Buana; Asty, Zahra Frizki; Wijayanti, Zilzikridini
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 7 No. 2 (2024): MEDIC. Medical dedication
Publisher : Universitas Jambi

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Diabetes Melitus remains a prominent health challenge globally, particularly in Indonesia, and is therefore included in the country’s disease prevention and control programs. One effective strategy for diabetes Melitus prevention is through community-based education and screening initiatives. This community service activity aimed to provide free facilitation for community members to learn about diabetes Melitus, undergo health checks specifically for random blood glucose levels, then consult with a physician regarding their examination results. The community service activity was conducted at the Letrysa Primary Clinic and began with a pre-test, followed by an educational and counseling session led by an internal medicine specialist. This was then followed by a post-test and screenings of participants' random blood glucose levels and blood pressure. Additionally, participants received free consultations with the internal medicine specialist based on their screening outcomes. The examination results indicated that out of 35 participants, three individuals had abnormal random blood glucose levels. An analysis of pre-test and post-test scores demonstrated that the education and counseling sessions significantly improved participants' understanding and knowledge of diabetes Melitus. Based on these findings, it is recommended that this program be conducted routinely within communities to help prevent Diabetes Melitus.

Kajian Manfaat Diet Mediterania: Analisis Priskila, Loury; Perkasa, Tengku Arief Buana; Wijaya, Yogik Onky Silvana
Cermin Dunia Kedokteran Vol 51 No 11 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i11.1265

The rapid growth of nutrigenomics and nutrigenetics has greatly contributed to understanding the importance of genetic, nutrition, and environmental interaction in maintaining human health. Healthy lifestyles such as adequate physical activity and healthy diet patterns have been widely reported may reduce the risk of various diseases. One of the health diet patterns that has been widely studied is the Mediterranean diet (MedDiet). MedDiet is a plant-based diet pattern high in fiber, high in unsaturated fatty acids, and low in meat and dairy products. This literature study aims to summarize the health benefits of the MedDiet pattern and its biomechanisms.

INTERACTIVE VISUAL EDUCATION TO ENHANCE KNOWLEDGE OF LOW BACK PAIN AMONG THE ELDERLY AND CAREGIVERS AT OLAK KEMANG HEALTH CARE, JAMBI CITY Humaryanto, Humaryanto; Attiya istarini; Lipinwati, Lipinwati; Perkasa, Tengku Arief Buana; Ahmad Syauqy; Hasna Dewi; Fitriyanti; Juanda, Syahreza Hadi; Zikri, Rahmat
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 8 No. 2 (2025): MEDIC. Medical dedication (In Progress)
Publisher : Universitas Jambi

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Low back pain is a common degenerative illness among the elderly, significantly impacting their quality of life and independence. Insufficient understanding of effective management frequently worsens the disease. The objective of this community service program was to enhance comprehension of low back pain among elderly and their caregivers at the Olak Kemang Public Health Centre in Jambi City. The programme consisted of an instructional session with 41 participants utilising a multidisciplinary-developed interactive visual module, accompanied by a practical demonstration of stretching exercises. A pre- and post-test design was used to quantitatively evaluate the alteration in participants' knowledge. The data were examined with the Wilcoxon and Pearson chi-square tests. The findings indicated a statistically significant enhancement in participants' knowledge, with the median score increasing from 60 (range: 30-80) in the pre-test to 85 (range: 50-100) in the post-test (p < 0.001). The number of participants who attained a passing score (≥70%) rose considerably from 19 to 31 (p = 0.007). The interactive visual education program effectively enhances awareness regarding lowback pain among the elderly and their caregivers. This strategy is highly recommended for implementation in other community health programs. Keywords: Low back pain; caregiver; health education; elderly

STRENGTHENING HEALTH CADRES THROUGH STRUCTURED TRAINING FOR COMMUNITY-BASED OBESITY SCREENING Maharani, Citra; Puspasari, Anggelia; Syauqy, Ahmad; Fitri, Amelia Dwi; Shafira, Nyimas Natasha Ayu; Perkasa, Tengku Arief Buana; Hasmita, Debby
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 8 No. 2 (2025): MEDIC. Medical dedication (In Progress)
Publisher : Universitas Jambi

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Obesity is a major risk factors for non-communicable diseases, and its prevalence continues to increase in Indonesia. Community Health Centers, as primary healthcare providers, play a crucial role in obesity prevention through the empowerment of local health cadres. This community service aimed to enhance cadres’ knowledge and skills in early obesity detection. The program was implemented through a structured training consisting of material delivery and hands-on anthropometric measurement sessions, followed by field visits to Posyandu to evaluate cadres’ practical skills in performing anthropometric assessments. A total of 15 Posyandu cadres from the working area of Tahtul Yaman Community Health Center participated in this activity. The results showed a significant increase in knowledge, with median scores rising from 90 (range 50–100) in the pre-test to 100 (range 80–100) in the post-test (p = 0.007). The proportion of cadres achieving the passing score also increased from 53.3% to 100% (p = 0.006). Field observations indicated that most cadres were able to perform anthropometric examinations independently and in accordance with standard procedures. These findings suggest that structured training combined with practical field reinforcement may contribute to improving cadres’ competencies, thereby supporting their role in sustainable, community-based obesity prevention efforts. Keywords: Obesity screening; Health cadres; Anthropometry; Community health center.

Improving The Knowledge and Skills of Posyandu Cadres Regarding Diabetes Mellitus: An Efforts to Strengthen Primary Service Integration at the Tahtul Yaman Community Health Centre, Jambi City Shafira, Nyimas Natasha Ayu; Enis, Rina Nofri; Maharani, Citra; Fitri, Amelia Dwi; Perkasa, Tengku Arief Buana; Amatullah, Afifah; Hasmita, Debby
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 8 No. 2 (2025): MEDIC. Medical dedication (In Progress)
Publisher : Universitas Jambi

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ABSTRACT Diabetes mellitus (DM) is a significant public health challenge, with a rapidly increasing burden in Indonesia. Community health cadres (kader) are crucial for community-level prevention, yet many possess limited knowledge regarding DM management and prevention. This community engagement program aimed to enhance the knowledge, attitudes, and practices (KAP) of health cadres within the Tahtul Yaman Primary Health Center area in Jambi City, focusing on diabetes prevention and control. This program utilized a participatory action research approach involving 15 active community health cadres. The intervention, conducted between August and September 2025, consisted of structured training modules, interactive lectures, Focus Group Discussions (FGDs), skill-based simulations (including glucometer use), and the distribution of educational toolkits. A pre-test/post-test design was used to evaluate changes in knowledge, with data analyzed using the Wilcoxon signed-rank test. Qualitative data were gathered through reflection sessions and one-month post-training field observations. Participants showed a statistically significant improvement in knowledge regarding diabetes prevention and management. The median knowledge score increased from 60 (IQR 40–80) at pre-test to 80 (IQR 40–90) at post-test (p = 0.009). Qualitative findings revealed positive shifts in cadres’ attitudes and increased self-efficacy in communicating health information. Key themes identified included knowledge empowerment and enhanced readiness for community engagement. Follow-up observations confirmed that cadres successfully applied their new skills, such as conducting risk screenings and health education, during community Posyandu ILP sessions. A structured, participatory, and context-sensitive training program effectively enhanced the knowledge, attitudes, and practical skills of community health cadres in DM prevention. Empowering cadres through continuous mentorship and integrating such programs into local health systems offers a sustainable and scalable strategy to strengthen community resilience and advance chronic disease management. Keywords: Diabetes melitus, community health cadres, health education empowerment, non-communicable diseases primary health care. ABSTRAK Diabetes mellitus (DM) merupakan tantangan kesehatan masyarakat yang signifikan, dengan beban yang meningkat pesat di Indonesia. Kader kesehatan masyarakat (kader) memegang peran penting dalam pencegahan di tingkat masyarakat, namun banyak yang memiliki keterbatasan pengetahuan mengenai manajemen dan pencegahan DM. Program keterlibatan masyarakat ini bertujuan meningkatkan pengetahuan, sikap, dan praktik (KAP) kader kesehatan di wilayah Puskesmas Tahtul Yaman, Kota Jambi, dengan fokus pada pencegahan dan pengendalian diabetes. Program ini menggunakan pendekatan penelitian tindakan partisipatif yang melibatkan 15 kader aktif. Intervensi, yang dilaksanakan antara Agustus dan September 2025, meliputi modul pelatihan terstruktur, ceramah interaktif, Diskusi Kelompok Terfokus (FGD), simulasi berbasis keterampilan (termasuk penggunaan glukometer), serta pendistribusian paket alat edukasi. Desain pre-test/post-test digunakan untuk mengevaluasi perubahan pengetahuan, dengan analisis data menggunakan uji Wilcoxon tanda berpasangan. Data kualitatif dikumpulkan melalui sesi refleksi dan observasi lapangan satu bulan pasca-pelatihan. Peserta menunjukkan peningkatan pengetahuan yang signifikan secara statistik; skor median pengetahuan meningkat dari 60 (IQR 40–80) pada pre-test menjadi 80 (IQR 40–90) pada post-test (p = 0.009). Temuan kualitatif mengungkapkan perubahan sikap yang positif dan peningkatan efikasi diri kader dalam menyampaikan informasi kesehatan. Tema kunci yang muncul meliputi pemberdayaan pengetahuan dan kesiapan yang meningkat untuk keterlibatan masyarakat. Observasi tindak lanjut mengonfirmasi bahwa kader berhasil menerapkan keterampilan baru, seperti melakukan skrining risiko dan penyuluhan kesehatan, selama sesi Posyandu ILP di masyarakat. Program pelatihan yang terstruktur, partisipatif, dan sensitif terhadap konteks secara efektif meningkatkan pengetahuan, sikap, dan keterampilan praktis kader kesehatan masyarakat dalam pencegahan DM. Memberdayakan kader melalui pendampingan berkelanjutan dan mengintegrasikan program semacam ini ke dalam sistem kesehatan lokal menawarkan strategi yang berkelanjutan dan dapat diskalakan untuk memperkuat ketahanan komunitas dan memajukan pengelolaan penyakit kronis Kata kunci: Diabetes melitus, kader kesehatan masyarakat, pemberdayaan pendidikan kesehatan, pelayanan kesehatan primer untuk penyakit tidak menular

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