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All Journal PIONIR: Jurnal Pendidikan Jurnal Biologi Babasal
Masdar, Rinaldi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Other

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Peran Lisosom dalam Autophagy sebagai Mekanisme Seluler dalam Bertahan dari Stres Nutrisi Nurdin, Rizky Aprilliani; Masdar, Rinaldi; Adnan
Jurnal Biologi Babasal Vol. 4 No. 1: Edisi April 2025
Publisher : Program Studi Pendidikan Biologi FKIP Uniiversitas Muhammadiyah Luwuk

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32529/jbb.v4i01.4002

Abstract

Lysosomes function to degrade and recycle cellular components using enzymes that operate in an acidic environment. This organelle helps break down proteins and damaged organelles, supporting cellular renewal through autophagy. Autophagy is a cellular stress response, particularly during nutrient or growth factor deprivation, where intracellular components are recycled to supply energy and raw materials. The regulation of autophagy is controlled by mTOR and AMPK, which respond to the cell’s nutritional status. Previous studies have shown that autophagy is essential for cellular homeostasis and is linked to various diseases, including neurodegenerative disorders, cancer, and aging. In animal models, autophagy gene deficiencies can result in poor metabolism and early death. Research has also demonstrated how autophagy aids in clearing damaged mitochondria, paving the way for potential treatments for degenerative diseases. This study uses meta-analysis of various research findings to synthesize insights on lysosomes and autophagy under nutritional stress. Data were collected from relevant studies and analyzed statistically to assess the consistency of findings and the factors influencing autophagy. The meta-analysis aims to reinforce the connection between nutrient stress and autophagy and to evaluate the therapeutic potential of autophagy modulation. Results indicate that increased autophagy during nutrient stress can protect cells but may also contribute to disease pathology if not properly regulated. Therefore, further research into autophagy mechanisms and their therapeutic potential is necessary.
THE POTENTIAL OF THE DISTAR LEARNING MODEL TO ENHANCE STUDENTS’ COLLABORATION SKILLS Masdar, Rinaldi; Amalia, Huznul; Cahyana, Uki; Amelia, Ermy; Bahri, Arsad
PIONIR: JURNAL PENDIDIKAN Vol. 14 No. 2 (2025): PIONIR: JURNAL PENDIDIKAN
Publisher : Prodi PGMI FTK UIN Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/m7crn947

Abstract

This study aims to develop a valid and practical learning model, namely the Distar Learning Model, to improve students' collaboration skills. This research is a type of Research and Development (R&D) using the ADDIE model (Analysis, Design, Development, Implementation, Evaluation), and was conducted in the odd semester of the 2024/2025 academic year at SMA Negeri 9 Gowa. The research subjects were 36 students of class XII MIPA 5. The validation results showed that the guidebook obtained a feasibility score of 87.16% (feasible for use), teaching materials 88.6% (very valid), learning modules 94.16% (very valid), and the Student Worksheet (LKPD) obtained a score of 3.77 out of 4.00 (very valid). The practicality test showed that the model had an implementation success rate of 90.47%. These findings indicate that the Distar Learning Model is proven to be valid and practical, and has the potential to improve students' collaboration skills. This model is recommended for broader implementation to facilitate 21st-century learning that emphasizes collaboration and active student engagement. Keywords: Learning Model, Collaboration Skills, 21st Century Learning, Distar Learning
Co-Authors Adnan Amalia, Huznul Amelia, Ermy Arsad Bahri Cahyana, Uki Nurdin, Rizky Aprilliani