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All Journal Jurnal Biologi Babasal Edubiotik : Jurnal Pendidikan, Biologi dan Terapan
Masdar, Rinaldi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Immunology & microbiology Other

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Peran Lisosom dalam Autophagy sebagai Mekanisme Seluler dalam Bertahan dari Stres Nutrisi Nurdin, Rizky Aprilliani; Masdar, Rinaldi; Adnan
Jurnal Biologi Babasal Vol. 4 No. 1: Edisi April 2025
Publisher : Program Studi Pendidikan Biologi FKIP Uniiversitas Muhammadiyah Luwuk

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32529/jbb.v4i01.4002

Abstract

Lysosomes function to degrade and recycle cellular components using enzymes that operate in an acidic environment. This organelle helps break down proteins and damaged organelles, supporting cellular renewal through autophagy. Autophagy is a cellular stress response, particularly during nutrient or growth factor deprivation, where intracellular components are recycled to supply energy and raw materials. The regulation of autophagy is controlled by mTOR and AMPK, which respond to the cell’s nutritional status. Previous studies have shown that autophagy is essential for cellular homeostasis and is linked to various diseases, including neurodegenerative disorders, cancer, and aging. In animal models, autophagy gene deficiencies can result in poor metabolism and early death. Research has also demonstrated how autophagy aids in clearing damaged mitochondria, paving the way for potential treatments for degenerative diseases. This study uses meta-analysis of various research findings to synthesize insights on lysosomes and autophagy under nutritional stress. Data were collected from relevant studies and analyzed statistically to assess the consistency of findings and the factors influencing autophagy. The meta-analysis aims to reinforce the connection between nutrient stress and autophagy and to evaluate the therapeutic potential of autophagy modulation. Results indicate that increased autophagy during nutrient stress can protect cells but may also contribute to disease pathology if not properly regulated. Therefore, further research into autophagy mechanisms and their therapeutic potential is necessary.
Free nutritious meal program and healthy eating behavior: The mediating roles of knowledge and awareness Masdar, Rinaldi; Taiyeb, A. Mushawwir; Jamaluddin, Asham Bin; Daud, Firdaus; Syamsiah
Edubiotik : Jurnal Pendidikan, Biologi dan Terapan Vol. 11 No. 01 (2026): May
Publisher : Biology Education Department, Universitas Insan Budi Utomo, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33503/ebio.v11i01.3182

Abstract

The Free Nutritious Meal Program (FNMP), known in Indonesia as Makan Bergizi Gratis (MBG), is a government initiative designed to improve students' nutritional status and promote healthy eating behavior. However, evidence regarding how the program influences students’ eating behavior remains limited. This study examined the effect of FNMP implementation on healthy eating behavior, digestive system knowledge, and nutritional awareness, as well as the mediating roles of knowledge and awareness. A cross-sectional survey was conducted among 622 eleventh-grade students from five public senior high schools in Makassar, Indonesia, selected through multistage sampling. Data were collected using questionnaires and multiple-choice tests and subsequently analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM). The results showed that the FNMP implementation had a significant positive effect on healthy eating behavior (β = 0.089, p = 0.043). However, the FNMP implementation did not significantly affect digestive system knowledge or nutritional awareness. Consequently, neither variable mediated the relationship between FNMP implementation and healthy eating behavior. These findings indicate that the FNMP directly improves healthy eating behavior through school-based interventions. Integrating nutrition education into the program may strengthen its effectiveness in promoting sustainable healthy eating practices among students.
Co-Authors A. Mushawwir Taiyeb, A. Mushawwir Adnan Asham Bin Jamaluddin Firdaus Daud Nurdin, Rizky Aprilliani Syamsiah