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All Journal JURNAL KIMIA SAINS DAN APLIKASI
Meilina, Tika
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Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering

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The Effect of Meloxicam Nanocrystal Formation with the Addition of PVP K-60 and Decyl Glucoside as Stabilizers on Its Solubility Sutarna, Titta Hartyana; Meilina, Tika; Al-Hakim, Nur Achsan
Jurnal Kimia Sains dan Aplikasi Vol 28, No 4 (2025): Volume 28 Issue 4 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.4.200-207

Abstract

Meloxicam (MLX) is a non-steroidal anti-inflammatory drug that has low bioavailability when administered orally due to its low solubility, and efforts have been made to improve drug delivery to improve solubility. The aim of this study was to prepare and characterize Meloxicam nanocrystals (MLX-NC) and evaluate them with the addition of polyvinylpyrrolidone K-60 (PVP K-60) and decyl glucoside (DG) to prevent nanoparticle aggregation. MLX-NC preparation by a combination of ultrasonic homogenization and the freeze-drying method. The particle size analysis results ranged from 9.76 to 12.73 nm with a polydispersity index <0.5, indicating a homogeneous and stable size distribution. PXRD and DSC characterization revealed the disappearance of the characteristic crystalline peaks of MLX, indicating a transformation to an amorphous form. Additionally, based on saturated solubility studies, the solubility of MLX-NC increased by up to 173 times compared to pure MLX. This study shows that the formulation, initially intended as nanocrystals, resulted in an amorphous solid dispersion due to the influence of stabilizer concentration. This transformation, along with reduced particle size, contributed synergistically to the enhanced solubility of MLX.
Co-Authors Hartyana Sutarna, Titta Nur Achsan Al-Hakim