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All Journal JURNAL KIMIA SAINS DAN APLIKASI Majalah Obat Tradisional Medika Kartika : Jurnal Kedokteran dan Kesehatan Indonesian Journal of Pharmaceutical Education Journal of Pharmaceutical and Sciences. Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi
Nur Achsan Al-Hakim
Universitas Jenderal Achmad Yani
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Solubility and Scale-Up Potency of Norfloxacin-Urea Co-Crystal Prepared by Ultrasound-Assisted Slurry Co-Crystallization Method Fikri Alatas; Dery Stiawan; Nur Achsan Al-Hakim
Borneo Journal of Pharmacy Vol. 6 No. 2 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i2.4173

Abstract

Norfloxacin is an antimicrobial in treating urinary tract infections with low water solubility. This study aims to know the effect of norfloxacin-urea co-crystal formation on the solubility of norfloxacin and the potential for scale-up when prepared by ultrasound-assisted slurry co-crystallization method. Identification of the screening result of the norfloxacin-urea (1 : 1) co-crystal formation by a wet grinding method using an ethanol-acetone (1 : 1) solvent mixture was performed by powder X-ray diffractometer (PXRD). The ultrasound-assisted slurry co-crystallization method was used for co-crystal formation with five-fold the weight of norfloxacin and urea than the wet grinding method. The co-crystal product prepared by the ultrasound-assisted slurry co-crystallization method was observed for its crystal morphology and characterized by PXRD and differential scanning calorimeter (DSC). Solubility and dissolution tests in water and acetate buffer solution pH 4.0 were used to evaluate the physicochemical properties. Identification of co-crystal screening by PXRD revealed the formation of norfloxacin-urea co-crystal. The PXRD pattern of the norfloxacin-urea co-crystal product prepared by the ultrasound-assisted slurry co-crystallization method was similar to the wet grinding method. Norfloxacin-urea co-crystal has a different melting point and crystal morphology from pure norfloxacin and urea. The solubility and dissolution rate of norfloxacin-urea co-crystal was higher in water and not significantly different in acetate buffer solution pH 4.0 compared to pure norfloxacin. This study showed that the norfloxacin-urea co-crystal formation could enhance the solubility of norfloxacin in water and had the potential for scale-up when prepared using the ultrasound-assisted slurry co-crystallization method.
PEMANFAATAN EKSTRAK DAUN TEH HIJAU (Camellia sinensis L) SEBAGAI BAHAN AKTIF PEMBUATAN SEDIAAN KRIM TABIR SURYA Titta Hartyana Sutarna; Fikri Alatas; Nur Achsan Al Hakim
Kartika : Jurnal Ilmiah Farmasi Vol 4 No 2 (2016)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v4i2.64

Abstract

ABSTRACTSenyawa yang mampu menghambat oksidasi molekul lain adalah senyawa antioksidan. Daun teh hijau dikenal sebagai tanaman yang mengandung senyawa katekin. Senyawa katekin  diketahui merupakan antioksidan. Dari penelitian yang dilakukan, daun teh hijau diketahui memiliki IC50 sebesar 3,17µg/mL. Penelitian ini ditujukan untuk memanfaatkan daun teh hijau sebagai zat aktif dalam sediaan krim antioksidan. Dibuat 4 Formulasi sediaan krim antioksidan yaitu F0 yang berisi basis krim tanpa ekstrak daun teh hijau dan F1, F2 serta F3 yang masing-masing berisi 0,5%; 1% dan 5%. Evaluasi sediaan meliputi pemeriksaan organoleptis, pengukuran pH, viskositas dan stabilitas antioksidan selama penyimpanan 28 hari. Hasil menunjukkan baik F0, F1, F2 maupun F3 tidak mengalami perubahan secara organoleptis, pengukuran pH dan viskositas dapat dikatakan stabil. Hasil pengukuran persen peredaman pada formulasi F0, F1,F2 dan F3 pada hari ke 28 menunjukkan nilai persen peredaman masing-masing yaitu 50,44%; 88,92%; 92,86%; 94,46%.  Kata Kunci: Camellia sinensis L, Ekstrak daun Teh Hijau, krim, antioksidan.
Formulation and Physical Evaluation of Orthosiphon aristatus Leaf Extract Granule Preparation as Herbal Beverage Candidate Al-Hakim, Nur Achsan; Nur Fauziyyah, Salma Alifia; Purnamasari, Nira; Faramayuda, Fahrauk
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.91009

Abstract

Developing Orthosiphon aristatus (Blume) Miq. leaf extract of purple varieties into granule dosage forms is expected to facilitate consumption, storage, and can extend the shelf life of the product. This study aims to develop the formulation and evaluation of granule preparations of O. aristatus leaf extract of purple varieties, with a comparison of lactose and maltodextrin fillers to produce the best formula. The granule dosage forms were prepared using wet granulation method. Furthermore, the variation of granule preparation formula consists of F1 (extract with lactose), F2 (extract with maltodextrin), F3 (extract with a combination of lactose and maltodextrin 1:1), F4 (freeze dried extract with lactose), F5 (freeze dried extract with maltodextrin), and F6 (freeze dried extract with a combination of lactose and maltodextrin 1:1). The physical evaluation of granules comprised moisture content testing, flowability, compressibility index, particle size distribution, and granule dissolving time. Results from the physical evaluation of granules over 28 days of storage indicated that all six formulas met the criteria for good granules, with F3 emerging as the optimal formula due to its superior physical stability and visually appealing appearance upon dissolution. To conclude, this study demonstrates that O. aristatus leaf extract can be effectively formulated into instant granule preparations suitable for herbal beverage or alternative medicine. Moreover, by modifying the filler material, the physical stability of the granule preparation can be maintained.
Evaluation of Sunflower Seed Oil Emulgel with Carbopol 940: Physical Properties and Moisturizing Effectiveness Anggraeni, Wulan; Al-Hakim, Nur Achsan; Maharani, Nur Intan
Indonesian Journal of Pharmaceutical Education Vol 5, No 1 (2025): January–April 2025
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v5i1.29584

Abstract

Sunflower seed oil is sourced from Helianthus annuus L., which is a plant that is extremely rich in essential fatty acids and antioxidants, so it can be used as a natural moisturizer that helps prevent, reduce, and protect skin from dryness. The purpose of this study was to evaluate the effect of variations in Carbopol 940 concentration on the physical properties and moisture effectiveness of sunflower seed oil emulgel dosage forms. The formulas were made into 3 formulas, with each concentration of Carbopol 940 for each formula, namely F1 (1%), F2 (1.5%), and F3 (2%). Furthermore, organoleptic, homogeneity, pH, viscosity and spreadability tests were carried out, as well as irritation and moisture effectiveness tests. The results of statistical analysis using one-way ANOVA showed a significant difference (P 0.05) which clarified that F1 provided an optimal increase in skin moisture (50.00%) compared to F2 (42.75%) and F3 (45.55%) and had good and stable physical properties evaluation results. In addition, increasing the concentration of Carbopol 940 in F2 and F3 can increase viscosity, but this actually affects the stability of the physical properties and moisture effectiveness of the preparation. This research concluded that F1 is the best formula and this study provides important information for the development of effective and stable skin moisturizing products, with recommendations for the use of effective concentrations of Carbopol 940 in the formulation of emulgel dosage forms.
The Effect of Meloxicam Nanocrystal Formation with the Addition of PVP K-60 and Decyl Glucoside as Stabilizers on Its Solubility Sutarna, Titta Hartyana; Meilina, Tika; Al-Hakim, Nur Achsan
Jurnal Kimia Sains dan Aplikasi Vol 28, No 4 (2025): Volume 28 Issue 4 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.4.200-207

Abstract

Meloxicam (MLX) is a non-steroidal anti-inflammatory drug that has low bioavailability when administered orally due to its low solubility, and efforts have been made to improve drug delivery to improve solubility. The aim of this study was to prepare and characterize Meloxicam nanocrystals (MLX-NC) and evaluate them with the addition of polyvinylpyrrolidone K-60 (PVP K-60) and decyl glucoside (DG) to prevent nanoparticle aggregation. MLX-NC preparation by a combination of ultrasonic homogenization and the freeze-drying method. The particle size analysis results ranged from 9.76 to 12.73 nm with a polydispersity index <0.5, indicating a homogeneous and stable size distribution. PXRD and DSC characterization revealed the disappearance of the characteristic crystalline peaks of MLX, indicating a transformation to an amorphous form. Additionally, based on saturated solubility studies, the solubility of MLX-NC increased by up to 173 times compared to pure MLX. This study shows that the formulation, initially intended as nanocrystals, resulted in an amorphous solid dispersion due to the influence of stabilizer concentration. This transformation, along with reduced particle size, contributed synergistically to the enhanced solubility of MLX.
Formulasi dan Evaluasi Fisik Sediaan Granul Stevia Sebagai Pemanis Alami Dengan Penambahan Polivinilpirolidon (PVP) Sebagai Pengikat Al-Hakim, Nur Achsan; Ratih , Hestiary; Sabrilla , Niken
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.661

Abstract

The development of natural sweetener discoveries continues to be carried out to realize healthy living behavior in its use in food and beverage products, including in the formulation of pharmaceutical preparations. Stevia (Stevia rebaudiana) is a plant that contains high sweetness and has the lowest caloric value. This study aims to formulate and physically evaluate stevia extract granule preparations using the wet granulation method with the addition of varying concentrations of Polyvinylpyrrolidone (PVP) as a binder, F0 (without PVP), F1 (1%), F2 (3%), and F3 (5%). Physical evaluation of stevia granule preparation includes organoleptic test, moisture content, flow rate, angle of repose, compressibility index and granule dissolving time in water. The results of the physical evaluation of granule preparations during 28 days storage showed that F3 was the best formula compared to other formulas, as evidenced by the results of statistical analysis using the one-way ANOVA method showing significant differences (p<0.05) between formulations. The evaluation results obtained were moisture content (<3%), flow rate (10.23 g/sec), angle of repose (27°), compressibility index (10%) and granule dissolving time (<1 minute). This study shows that the use of 5% PVP concentration in F3 as a binder can improve the physical properties of stevia granule preparations to be better than 1% and 3% concentrations.
PENGARUH KOMBINASI HIDROKSIPROPIL METIL SELULOSA DAN CARBOPOL® 940 TERHADAP SIFAT FISIK DAN STABILITAS ANTIOKSIDAN GEL SLEEPING MASK EKSTRAK KAYU SECANG Al-Hakim, Nur Achsan; Pratiwi, Gladdis Kamilah; Alatas, Fikri; Rahayu, Novitri Sri
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 7 No 1 (2024): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Perawatan kulit menjadi salah satu upaya dalam mencegah penuaan dini, diantaranya dengan memanfaatkan bahan alami sebagai sumber antioksidan. Kayu secang (Caesalpinia sappan L.) merupakan salah satu tumbuhan yang mengandung antioksidan. Penelitian ini bertujuan untuk mengetahui pengaruh variasi kombinasi bahan pembentuk gel hidroksipropil metil selulosa (HPMC) dan Carbopol® 940 pada formulasi gel sleeping mask ekstrak kayu secang terhadap sifat fisik dan stabilitas antioksidannya. Sediaan gel sleeping mask dibuat dengan lima variasi rasio HPMC dan Carbopol® 940, yaitu 5:0 (F1), 0:5 (F2), 2,5:2,5 (F3), 3:2 (F4), dan 3,5:1,5 (F5). Evaluasi fisik sediaan meliputi organoleptik, pengukuran pH dan viskositas, homogenitas, uji daya sebar, serta penentuan stabilitas fisik aktivitas antioksidan sediaan gel sleeping mask. Aktivitas antioksidan ditetapkan menggunakan metode 2,2-difenil-1-pikrilhidrazil (DPPH). Hasil evaluasi fisik sediaan gel sleeping mask menunjukkan bahwa F5 merupakan formula yang terbaik dan stabil selama penyimpanan 28 hari, dan memenuhi parameter ideal sediaan kosmetik topikal, serta memiliki aktivitas antioksidan yang stabil. Penelitian ini menunjukkan bahwa ekstrak kayu secang dapat diformulasikan menjadi sediaan gel sleeping mask dan dengan memodifikasi agen pengental dalam formulasi menghasilkan sediaan yang baik dan stabil, serta penelitian ini menjadi pertimbangan ilmiah sebagai terapi alternatif dalam upaya mencegah penuaan dini. Kata kunci : antioksidan, Carbopol® 940, ekstrak kayu secang, HPMC, gel sleeping mask DOI : 10.35990/mk.v7n1.p45-56
Co-Authors Dery Stiawan Fahrauk Faramayuda, Fahrauk Fikri Alatas Hartyana Sutarna, Titta Maharani, Nur Intan Meilina, Tika Nira Purnamasari, Nira Nur Fauziyyah, Salma Alifia Pratiwi, Gladdis Kamilah Rahayu, Novitri Sri Ratih , Hestiary Sabrilla , Niken Wulan Anggraeni, Wulan