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All Journal Jurnal Mahasiswa Ilmu Kesehatan Vitamin: Jurnal Ilmu Kesehatan Umum
Maura Putri Ariqah
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Health Professions Nursing Public Health

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Uji Stabilitas Fisik dan Kimia Sediaan Tablet Parasetamol dalam Berbagai Kondisi Penyimpanan M. Jian Prayoga; Maulida Maulida; Maura Putri Ariqah; Nor Latifah
Vitamin : Jurnal ilmu Kesehatan Umum Vol. 3 No. 3 (2025): Juli: Vitamin : Jurnal ilmu Kesehatan Umum
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/vitamin.v3i3.1458

Abstract

Paracetamol is a widely used analgesic and antipyretic drug in tablet dosage form. Ensuring the stability of paracetamol tablets is essential to maintain drug efficacy, safety, and quality during their shelf life. This study aims to evaluate the physical and chemical stability of paracetamol tablets stored under different temperature and humidity conditions. The review method used in this article involves analyzing published data from several sources, focusing on changes in physical appearance (color, shape, and odor) and chemical parameters such as active pharmaceutical ingredient content over time. The findings indicate that higher temperatures and humidity accelerate degradation and affect the drug's quality, particularly through discoloration and reduction in active content. Packaging also plays a crucial role in maintaining stability, especially in tropical climates. The results highlight the importance of stability testing in pharmaceutical quality assurance and support the application of Good Manufacturing Practices (GMP) and appropriate storage guidelines. This paper contributes to the understanding of stability profiles of commonly used drugs and provides a reference for the formulation and packaging development of heat-sensitive medications.
Aplikasi Silika Gel dalam Fraksinasi Senyawa Bioaktif dari Tanaman Obat Muhammad Rezky Wahyudi; Jannatun Nisa; Maulida Maulida; Maura Putri Ariqah; M. Jian Prayoga; Nicky Saputra; Noor Kamalliyah
Jurnal Mahasiswa Ilmu Kesehatan Vol. 3 No. 3 (2025): Jurnal Mahasiswa Ilmu Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/jumkes.v3i3.3157

Abstract

Silica gel is one of the most commonly used adsorbents in the fractionation of bioactive compounds from medicinal plants. This is due to its ability to separate compounds based on differences in polarity, thus simplifying the purification process of active components. Fractionation itself is a crucial step in phytochemical research, as it aims to obtain active compounds in a purer, standardized form, and ready for further testing, both biologically and pharmacologically. This study aims to review the effectiveness of silica gel in the fractionation of active compounds from various types of medicinal plants. The study was conducted through a systematic literature review method with a qualitative-descriptive approach to 35 scientific articles published in the last five years. The articles analyzed were those that presented primary data on the use of silica gel in the fractionation process of medicinal plants. The results of the study showed that silica gel was proven effective in separating various polar compounds such as flavonoids, alkaloids, and phenolic compounds from crude extracts of medicinal plants. Some studies have even succeeded in isolating pure compounds that have significant biological activities, such as antioxidants, antimicrobials, and anti-inflammatory. The effectiveness of fractionation with silica gel is influenced by several important factors, such as the type and composition of the solvent, the elution technique (gradient or isocratic), and the support of advanced analytical methods such as thin-layer chromatography (TLC) and spectroscopy (UV-Vis, FTIR, and NMR). However, the use of silica gel still has several limitations, including the relatively high solvent requirements and long elution times. From the results of this study, it can be concluded that silica gel has great potential in supporting the fractionation process and isolation of bioactive compounds from medicinal plants. Therefore, optimization of silica gel-based fractionation techniques is important to support research and development of more efficient, standardized, and sustainable phytopharmaceutical products.
Co-Authors Jannatun Nisa M. Jian Prayoga Maulida Maulida Muhammad Rezky Wahyudi Nicky Saputra Noor Kamalliyah Nor Latifah