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All Journal Jurnal Mahasiswa Ilmu Kesehatan Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Noor Kamalliyah
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Dentistry Health Professions Nursing Public Health Veterinary

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Artikel Review : Pengaruh Perbedaan Bahan Pengikat Sintesis dan Alami dalam Sediaan Tablet Hisap Annisa Annisa; Khusnul Khotimah; Nabila Sativa; Noor Kamalliyah; Siti Nor Adidah; Nor Latifah
An-Najat Vol. 2 No. 4 (2024): NOVEMBER - An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v2i4.1979

Abstract

A lozenge is a form of solid pharmaceutical preparation designed to dissolve slowly in the oral cavity, providing both local and systemic effects. In lozenge formulation, binders play an important role in ensuring tablet hardness and appropriate dissolution time. This study aims to compare the effects of synthetic and natural binders on the physical properties and performance of lozenges. Synthetic binders such as PVP, CMC Na, and Hydroxypropyl Methylcellulose (HPMC) tend to provide higher tablet hardness and more controlled dissolution times. Meanwhile, natural binders such as maltodextrin, gum arabic, and jackfruit seed starch show good abilities to enhance tablet cohesion, with the additional benefits of biocompatibility and biodegradability. The research results indicate that synthetic binders provide better physical stability, while natural binders are preferred due to their environmentally friendly properties and ability to improve patient acceptance.
Aplikasi Silika Gel dalam Fraksinasi Senyawa Bioaktif dari Tanaman Obat Muhammad Rezky Wahyudi; Jannatun Nisa; Maulida Maulida; Maura Putri Ariqah; M. Jian Prayoga; Nicky Saputra; Noor Kamalliyah
Jurnal Mahasiswa Ilmu Kesehatan Vol. 3 No. 3 (2025): Jurnal Mahasiswa Ilmu Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/jumkes.v3i3.3157

Abstract

Silica gel is one of the most commonly used adsorbents in the fractionation of bioactive compounds from medicinal plants. This is due to its ability to separate compounds based on differences in polarity, thus simplifying the purification process of active components. Fractionation itself is a crucial step in phytochemical research, as it aims to obtain active compounds in a purer, standardized form, and ready for further testing, both biologically and pharmacologically. This study aims to review the effectiveness of silica gel in the fractionation of active compounds from various types of medicinal plants. The study was conducted through a systematic literature review method with a qualitative-descriptive approach to 35 scientific articles published in the last five years. The articles analyzed were those that presented primary data on the use of silica gel in the fractionation process of medicinal plants. The results of the study showed that silica gel was proven effective in separating various polar compounds such as flavonoids, alkaloids, and phenolic compounds from crude extracts of medicinal plants. Some studies have even succeeded in isolating pure compounds that have significant biological activities, such as antioxidants, antimicrobials, and anti-inflammatory. The effectiveness of fractionation with silica gel is influenced by several important factors, such as the type and composition of the solvent, the elution technique (gradient or isocratic), and the support of advanced analytical methods such as thin-layer chromatography (TLC) and spectroscopy (UV-Vis, FTIR, and NMR). However, the use of silica gel still has several limitations, including the relatively high solvent requirements and long elution times. From the results of this study, it can be concluded that silica gel has great potential in supporting the fractionation process and isolation of bioactive compounds from medicinal plants. Therefore, optimization of silica gel-based fractionation techniques is important to support research and development of more efficient, standardized, and sustainable phytopharmaceutical products.
Co-Authors Annisa Annisa Jannatun Nisa Khusnul Khotimah M. Jian Prayoga Maulida Maulida Maura Putri Ariqah Muhammad Rezky Wahyudi Nabila Sativa Nicky Saputra Nor Latifah Siti Nor Adidah