Article Per Year (5 Year)
p-Index From 2020 - 2025
0.408
P-Index
This Author published in this journals
All Journal Jurnal Mahasiswa Ilmu Kesehatan Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Jannatun Nisa
Unknown Affiliation
Health Professions Nursing Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Uji Stabilitas Obat Sediaan Tablet: Prinsip, Pedoman ICH Q1, dan Parameter Kritis Jannatun Nisa; Nicky Saputra; Nor Latifah
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 4 (2025): July: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i4.1507

Abstract

This article provides a comprehensive review of drug stability testing, specifically focusing on tablet dosage forms. It elucidates the fundamental principles, the critical role of ICH Q1 guidelines, and essential parameters evaluated during stability studies, including physical, chemical, and microbiological aspects. The discussion covers various types of stability studies, standardized storage conditions, and the interpretation of results for determining shelf life and ensuring product quality. Relevant case studies on tablet stability are also integrated to illustrate practical applications. This review aims to provide a structured overview of stability testing methodologies and their significance in pharmaceutical development and quality assurance.
Aplikasi Silika Gel dalam Fraksinasi Senyawa Bioaktif dari Tanaman Obat Muhammad Rezky Wahyudi; Jannatun Nisa; Maulida Maulida; Maura Putri Ariqah; M. Jian Prayoga; Nicky Saputra; Noor Kamalliyah
Jurnal Mahasiswa Ilmu Kesehatan Vol. 3 No. 3 (2025): Jurnal Mahasiswa Ilmu Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/jumkes.v3i3.3157

Abstract

Silica gel is one of the most commonly used adsorbents in the fractionation of bioactive compounds from medicinal plants. This is due to its ability to separate compounds based on differences in polarity, thus simplifying the purification process of active components. Fractionation itself is a crucial step in phytochemical research, as it aims to obtain active compounds in a purer, standardized form, and ready for further testing, both biologically and pharmacologically. This study aims to review the effectiveness of silica gel in the fractionation of active compounds from various types of medicinal plants. The study was conducted through a systematic literature review method with a qualitative-descriptive approach to 35 scientific articles published in the last five years. The articles analyzed were those that presented primary data on the use of silica gel in the fractionation process of medicinal plants. The results of the study showed that silica gel was proven effective in separating various polar compounds such as flavonoids, alkaloids, and phenolic compounds from crude extracts of medicinal plants. Some studies have even succeeded in isolating pure compounds that have significant biological activities, such as antioxidants, antimicrobials, and anti-inflammatory. The effectiveness of fractionation with silica gel is influenced by several important factors, such as the type and composition of the solvent, the elution technique (gradient or isocratic), and the support of advanced analytical methods such as thin-layer chromatography (TLC) and spectroscopy (UV-Vis, FTIR, and NMR). However, the use of silica gel still has several limitations, including the relatively high solvent requirements and long elution times. From the results of this study, it can be concluded that silica gel has great potential in supporting the fractionation process and isolation of bioactive compounds from medicinal plants. Therefore, optimization of silica gel-based fractionation techniques is important to support research and development of more efficient, standardized, and sustainable phytopharmaceutical products.
Co-Authors M. Jian Prayoga Maulida Maulida Maura Putri Ariqah Muhammad Rezky Wahyudi Nicky Saputra Noor Kamalliyah Nor Latifah