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All Journal Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam
Muhammad Ali Sabisi
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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HUBUNGAN ANTARA EKSPRESI CASPASE 3 DENGAN PROGRESIVITAS KANKER SERVIKS STADIUM IIA2 DAN IIB POST KEMOTERAPI NEOADJUVAN RSUP DR SARDJITO YOGYAKARTA Erika Kusumawardani; Muhammad Ali Sabisi
Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam Vol 15 No 2 (2025): Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam
Publisher : Universitas Batam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37776/zked.v15i2.1817

Abstract

ABSTRAK LATAR BELAKANG: Kanker serviks merupakan salah satu kanker pada perempuan yang memiliki angka kejadian dan kematian yang tinggi di Indonesia. Pada kanker serviks stadium IIA2 dan IIB dikenal modalitas kemoterapi neoadjuvan sebelum operasi radikal yang bertujuan untuk mengurangi massa tumor sehingga memudahkan pembedahan dan menghambat mikrometastasis. Infeksi Human Papilloma Virus (HPV) merupakan faktor penting penyebab kanker serviks. Protein caspase 3 yang berperan dalam proses apoptosis berkaitan dengan patogenesis kanker serviks. Sampai saat ini, belum ada prediktor yang dapat digunakan untuk memprediksi progresivitas kanker serviks stadium IIA2 dan IIB setelah pemberian kemoterapi neoadjuvan. BACKGROUND: Cervical cancer is a cancer in women that has a high incidence and mortality in Indonesia. In stage IIA and IIB cervical cancer, neoadjuvant chemotherapy modality is known before radical surgery which aims to reduce tumor mass to facilitate surgery and inhibit micrometastatic. Human Papilloma Virus (HPV) infection is an important factor in causing cervical cancer. Caspase 3 protein which plays a role in the apoptosis process related to the pathogenesis of cervical cancer. Nowadays, there are no predictors that can be used to predict the progresivity of stage IIA2 and IIB cervical cancer after presenting neoadjuvant chemotherapy. Kata kunci: kanker, serviks, caspase 3, progresivitas, kemoterapi
HUBUNGAN TINGKAT STRESS AKADEMIK DAN KEJADIAN GASTROESOPHAGEAL REFLUX DISEASE (GERD) PADA MAHASISWA PROFESI DOKTER PROGRAM STUDI KEDOKTERAN, FAKULTAS KEDOKTERAN UNIVERSITAS BATAM Muhammad Ali Sabisi; Erika Kusumawardani
Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam Vol 16 No 1 (2026): Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam
Publisher : Universitas Batam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37776/zked.v16i1.2094

Abstract

Introduction: Gastroesophageal reflux disease (GERD) is an upper gastrointestinal disorder caused by repeated reflux of gastric contents into the esophagus, leading to symptoms or complications. One of the risk factors for GERD is stress, which is commonly experienced by university students. This study aimed to determine the relationship between academic stress levels and the incidence of GERD among medical professional students of the Medical Study Program, Faculty of Medicine, Universitas Batam. Methods: This study employed a quantitative observational analytic design with a cross-sectional approach and utilized the Chi-square test. Total random sampling was applied based on inclusion and exclusion criteria. GERD was assessed using the GERD-Q questionnaire, while academic stress levels were measured using the Medical Student Stressor Questionnaire (MSSQ). Results: The results showed that a small proportion of students, 14.5% (9 students), experienced GERD symptoms. Nearly half of the respondents, 48.4% (30 students), experienced moderate stress, while 30.6% (13 students) experienced mild stress. A smaller proportion, 19.4% (12 students), experienced severe stress, and only 1.6% (1 student) experienced very severe stress. The Chi-square analysis revealed a p-value of 0.680 (p > 0.05) for the relationship between academic stress level and GERD incidence. Conclusion: There was no statistically significant relationship between academic stress level and the incidence of GERD among medical professional students. Keywords: Gastroesophageal reflux disease, GERD, GERD-Q, MSSQ, Academic stress
Co-Authors Erika Kusumawardani