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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Media Dermato-Venereologica Indonesiana Indonesian Journal of Biomedicine and Clinical Sciences
Niken Indrastuti
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Response of narrowband ultraviolet-B phototherapy combined with superoxide dismutase antioxidant cream in the management of non-segmental vitiligo Muchamad Apriyanto; Hanan Asrafi Noviandari; Niken Indrastuti; Arief Budiyanto
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.17224

Abstract

Vitiligo is a skin depigmentation disorder characterized by the loss of melanocyte function. The oxidative stress theory plays a role in the occurrence of vitiligo. Narrow band ultraviolet B (NB-UVB) phototherapy can be combined with other therapies to accelerate skin repigmentation. A 47 yo woman presented to the dermatology and venereology outpatient clinic in Dr. Sardjito General Hospital, Yogyakarta with a chief complaint of white patches on her face, neck, chest, and hands that had persisted for 11 yr. The patient had previously received NB-UVB phototherapy and a calcineurin inhibitor cream, but the symptoms persisted. Significant repigmentation of the lesion area was achieved after NB-UVB phototherapy combined with superoxide dismutase (SOD) antioxidant cream. NB-UVB phototherapy plays a role in immunomodulation, biostimulation, and reducing oxidative stress. The SOD helps clear superoxide radicals, preventing damage to melanocytes. The combination of NB-UVB phototherapy and antioxidant cream can be considered a treatment option for vitiligo.
Differences in Serum Albumin and Globulin Levels on the Severity of Radiodermatitis in Breast Cancer Patients at a Tertiary Hospital in Yogyakarta Novita Permatasari; Niken Indrastuti; Arief Budiyanto; Niken Trisnowati; Oktarina, Dyah Ayu Mira
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 38 No. 1 (2026): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V38.1.2026.20-26

Abstract

Background: Repeated and accumulated radiation exposure causes radiodermatitis in breast cancer patients. Lack of protein in the body can cause problems with wound healing induced by radiation exposure. Serum albumin and globulin levels are the most convenient protein components to assess. Purpose: To determine differences in serum albumin, serum globulin, and albumin/globulin (A/G) ratios for each grade of severity of radiodermatitis in breast cancer patients. Methods: This was an observational study with a cross-sectional design. Subjects were taken from the International Cancer Center at a tertiary hospital in Yogyakarta, who met the inclusion and exclusion criteria. A comparative analysis was performed to compare the means. Result: The number of radiodermatitis subjects were 32 patients, with 22 peoples in grade I, four peoples in grade II, and six peoples in grade III. The comparative test results showed differences in the average serum albumin levels for each severity grade: normal levels were obtained in radiodermatitis grades I and III, but low levels were obtained in grade II with a significant difference. There is a significant difference between serum albumin levels and each grade of severity of radiodermatitis. However, no significant results were obtained on serum globulin levels and A/G ratio. Conclusion: Serum albumin levels differ significantly according to the severity of radiodermatitis and may play a role in its progression, whereas serum globulin levels and A/G ratio are not associated. Albumin may be considered a potential clinical indicator in assessing radiodermatitis severity in breast cancer patients undergoing radiotherapy
Mukositis Oral Akibat Kemoterapi Raden Roro Rini Andayani; Niken Indrastuti; Satiti Retno Pudjiati; Sonia Diovani; Marcella Anggatama
Media Dermato-Venereologica Indonesiana Vol 53 No 2 (2026): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v53i2.532

Abstract

   Mukositis oral merupakan komplikasi umum pada pasien kanker yang menjalani kemoterapi atau radioterapi pada area kepala dan leher, dengan sekitar 40% pasien kemoterapi mengalami efek samping ini. Mukositis yang berat dan tidak tertangani dapat menghambat pengobatan kanker, memperpanjang waktu rawat inap, dan menurunkan kualitas hidup pasien. Memahami penegakan diagnosis mukositis oral akibat kemoterapi guna mencegah peningkatan keparahan dan meningkatkan kualitas hidup pasien. Mukositis oral merupakan komplikasi inflamasi mukosa yang secara klinis ditandai oleh eritema, ulserasi, nyeri, dan perdarahan. Patogenesisnya terdiri atas lima fase, yaitu inisiasi, inflamasi, amplifikasi sinyal kerusakan, ulserasi, dan penyembuhan. Derajat keparahan mukositis oral dinilai berdasarkan klasifikasi World Health Organization (WHO) dan National Cancer Institute – Common Terminology Criteria for Adverse Events (NCI-CTCAE), mulai dari derajat 1 (ringan) hingga derajat 5 (kematian akibat toksisitas kemoterapi). Insidensi dan tingkat keparahannya dipengaruhi oleh kerentanan pasien dan jenis kemoterapi yang digunakan. Penanganan mukositis oral meliputi perawatan dasar mulut, agen antiinflamasi, fotobiomodulasi dan metode pendinginan oral. Diagnosis dini dan penatalaksanaan yang tepat terhadap mukositis oral diharapkan dapat memperbaiki prognosis dan kualitas hidup pasien kanker yang menjalani kemoterapi. 
Co-Authors Arief Budiyanto Hanan Asrafi Noviandari Marcella Anggatama Muchamad Apriyanto Niken Trisnowati Novita Permatasari Oktarina, Dyah Ayu Mira Raden Roro Rini Andayani Satiti Retno Pudjiati Satiti Retno Pudjiati Sonia Diovani