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All Journal Biotropika Jurnal Biologi Universitas Andalas
Ilmiyah, Silvi Zakiyatul
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Virtual Based Screening of Rosmaniric Acid and Its Derivatives as Potential Anticancer Approach Targeting HIF-1a Naufal, Achmad Hanif; Wachid, Nisa Nabila Aufa; Kamila, Fairuz Sarah; Wahyuningsih, Nadia; Ilmiyah, Silvi Zakiyatul; Nafisah, Wirdatun; Fatchiyah, Fatchiyah
Biotropika: Journal of Tropical Biology Vol. 13 No. 1 (2025)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2025.013.01.03

Abstract

Cancer is one of the leading causes of death in the world. Rosmarinic acid becomes one of the important polyphenolic compounds. It includes derivatives of two amino acids, caffeic acid from phenylalanine and 3,4-dihydroxyphenyl-lactic acid from tyrosine, secondary metabolites found in many herbal plants from the subfamily Lamiaceae and Boraginaceae. Rosmarinic acid works in inhibiting the occurrence of metastases and tumor formation. In this study, we evaluated rosmarinic acid and its derivatives through study literature. The compounds were downloaded from the PubChem database, while the three-dimensional structure of HIF-1a was retrieved from RCSB PDB. The biological activity was analyzed using the PASS server, and the cytotoxic effect was predicted using CLC-Pred., The pharmacological properties of bioactive compounds were analyzed using SwissADME. The compounds and HIF-1a were prepared using PyRx 0.8 version and Discovery Studio software, docked specifically using Autodock Vina, visualized using Discovery Studio software, and molecular dynamic simulation using CABS-flex 2.0. Rosmarinic acid and its derivative showed an inhibition with the highest affinity value of compound against HIF-1a are control (-6.9 kcal/mol), Rosmarinic acid (-6.4 kcal /mol), and Methyl rosmarinate (-6.3 kcal/mol). Rosmarinic acid could be expected to have activity as an inhibitor modulated at the post-translational level. Comprehensive and further analysis is required in future research based in vivo and in vitro for the development of cancer treatments.
Identification of Ectoparasites on Aglaonema sp. in Ngerong Village, Pasuruan City with Visual Encounter Methods Ilmiyah, Silvi Zakiyatul; Setiyanto, Afif Eka Rahma; Ibrahim, Yudhistira; Yanuwiadi, Bagyo; Gama, Zulfaidah Penata
Jurnal Biologi Universitas Andalas Vol 12 No 2 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jbioua.12.2.122-128.2024

Abstract

Ornamental plants are plants that are used as decoration. One of the ornamental plants is Aglaonema sp. known as Sri Rejeki. It is enjoyed as an ornamental plant in terms of leaf pattern. However, Aglaonema has harmful ectoparasites. The aim of this study was to determine and identify ectoparasites in Aglaonema plants using the Visual Encounter method, and to analyze the role and solutions for the presence of ectoparasites in Aglaonema. Research observations were carried out for approximately three weeks from April to May 2022. Six individuals Aglaonema were used as samples. Observation was done by using the visual encounter method which was carried out once a week in the morning, afternoon, and evening with a total of three time observations (15 minutes each) at each time. Measurement of abiotic factors includes temperature, humidity, and weather. The results were used to determine the important value index (IVI) and Shannon-Wiener Index (H’). All identified organisms were arthropods (insects). There were five identified families:  Pseudococcidae, Coccidae, Formicidae, Chironomidae, and Muscidae. Pseudococcidae and Coccidae were the insect families that are confirmed as ectoparasites for plants. The solution for prevention or termination of ectoparasite is by replacing the invaded plant away from healthy plants, removing the infected parts of plant, and/or placing refugia plant for habitat of ectoparasite’s natural enemies.  
Co-Authors Bagyo Yanuwiadi fatchiyah . Ibrahim, Yudhistira Kamila, Fairuz Sarah Nafisah, Wirdatun Naufal, Achmad Hanif Setiyanto, Afif Eka Rahma Wachid, Nisa Nabila Aufa Wahyuningsih, Nadia Zulfaidah Penata Gama