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All Journal Biology, Medicine, & Natural Product Chemistry Jurnal Rekayasa Proses
Sakka, Deni Frans
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Medicine & Pharmacology Public Health

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Perbandingan jenis media imobilisasi terhadap kinerja proses peruraian anaerob termofilik palm oil mill effluent Sakka, Deni Frans; Millenia, Salsabilla Fitri; Prijambada, Irfan Dwidya
Jurnal Rekayasa Proses Vol 16 No 1 (2022): Volume 16, Number 1, 2022
Publisher : Jurnal Rekayasa Proses

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jrekpros.69582

Abstract

Palm oil mill effluent (POME) merupakan limbah cair dengan kandungan organik yang tinggi sebagai bahan baku produksi biogas melalui peruraian anaerob. Dalam peruraian anaerob, efek washout selalu menjadi masalah seiring dengan meningkatnya organic loading rate (OLR) pada sistem kontinu. Oleh karena itu, dilakukan penambahan media imobilisasi untuk mengurangi risiko tersebut. Penelitian ini bertujuan untuk mengevaluasi pengaruh jenis dan pengaturan media imobilisasi terhadap kinerja peruraian anaerob termofilik POME. Dua media imobilisasi yang diuji yaitu media jenis carbon fiber textile (CFT) dan media berupa partikel zeolit alam. Kinerja proses anaerob ditentukan dengan mengukur konsentrasi asam lemak volatil (VFA), soluble chemical oxygen demand (sCOD) dan yield metana (CH4). Hasil penelitian ini menunjukkan bahwa reaktor dengan media imobilisasi menghasilkan yield CH4 yang lebih tinggi dibandingkan dengan reaktor tanpa media imobilisasi. Yield CH4 reaktor dengan zeolit alam sebesar 0,3487 L/g sCOD, 0,3050 L/g sCOD pada reaktor dengan media CFT dan 0,2873 L/g sCOD pada reaktor tanpa media imobilisasi. Selain itu, hanya zeolit alam yang dapat mempertahankan performa reaktor saat mengalami gangguan peningkatan suhu secara tiba-tiba dengan masa recovery selama 14 hari.
Antibacterial Actinomycetes from Tropical Ecosystem Karst in South Sulawesi: Isolation, Characterization, and Bioactive Metabolite Profiling Ali, Alimuddin; Pasmawati, Pasmawati; Muslimin, Rukman; Hibatullah, Alnadia Yusriya; Sakka, Deni Frans; Soa, Christina Aryanti Pada; Buhaerah, Kusdianawati; Passitta, Muharram
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.253-262

Abstract

The emergence of antimicrobial-resistant pathogens reinforces the critical need for new antibiotics sourced from unexplored microbial habitats. Actinomycetes remain the most prolific bacterial producers of bioactive secondary metabolites, yet tropical karst ecosystems and plant-associated rhizospheres in Indonesia remain poorly investigated despite their ecological complexity. This study aimed to isolate, screen, and characterize Actinomycetes from the karst and rhizospheric environments of South Sulawesi, Indonesia, and to identify isolates capable of producing antibacterial compounds. A total of 42 isolates were obtained using heat-shock pretreatment and selective Starch Casein Agar. Preliminary antagonistic assays against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 35218 identified four active isolates. Two isolates KMR 1E2 and SDR 2a exhibited strong inhibition (>30 mm) against S. aureus, while SDR 9.9 inhibited E. coli. Morphological and phenotypic characterization revealed diverse spore-chain architectures, colony color profiles, carbon and nitrogen utilization patterns, salinity tolerance, melanin production, and variable growth under different pH and temperature conditions. Ethyl acetate extracts of KMR 1E2 and SDR 2a demonstrated potent antibacterial activity, and TLC-bioautography identified three active metabolites (Rf 0.73, 0.48, 0.34), with the Rf 0.34 spot associated with an alkaloid-type compound. The minimum inhibitory concentration (MIC) of KMR 1E2 extract against S. aureus was 0.3125 mg/mL. This study confirms that tropical karst ecosystems in Indonesia are promising reservoirs of antibiotic-producing Actinomycetes and provides a foundation for future genomic and chemical elucidation studies
Co-Authors Alimuddin Ali Buhaerah, Kusdianawati Hibatullah, Alnadia Yusriya Irfan Dwidya Prijambada Jendri Mamangkey Millenia, Salsabilla Fitri Muslimin, Rukman Pasmawati, Pasmawati Passitta, Muharram Raden Mohamad Herdian Bhakti Soa, Christina Aryanti Pada Wafaretta, Erona