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All Journal Prosiding Workshop dan Seminar Nasional Farmasi (WSNF) Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Putu Siska Angelina Pramesti
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Review: Fitokimia dan Aktivitas Farmakologi dari Alga Kappaphycus alvareziiz Putu Siska Angelina Pramesti; Putu Oka Samirana; Anak Agung Gede Rai Yadnya Putra
Prosiding Workshop dan Seminar Nasional Farmasi Vol. 3 (2024): Prosiding Workshop dan Seminar Nasional Farmasi 2024
Publisher : Program Studi Farmasi Fakultas MIPA Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/WSNF.2024.v03.p10

Abstract

Kappaphycus alvarezii merupakan salah satu alga merah yang termasuk ke dalam keluarga Solieriaceae. Kappaphycus alvarezii mayoritas dikembangkan di kawasan pesisir dan memiliki potensi ekonomi yang besar. Seiring berjalannya waktu, budidaya Kappaphycus alvarezii semakin terus meningkat karena mulai dikenal untuk kebutuhan industri makanan, farmasi, dan kosmetik. Kajian ini disusun dengan tujuan untuk merangkum senyawa fitokimia dan aktivitas farmakologi dari Kappaphycus alvarezii. Pencarian data diperoleh dari jurnal internasional dan nasional melalui database berbasis ilmiah yaitu Google Scholar, Science Direct, dan PubMed. Berdasarkan literatur yang telah dikumpulkan, sebanyak 13 artikel yang memenuhi kriteria inklusi. Hasilnya menunjukkan Kappaphycus alvarezii mengandung metabolit sekunder yaitu fenolik, flavonoid, alkaloid, terpenoid, dan sterol. Selain itu, isolat yang berhasil diisolasi dari tanaman ini salah satunya adalah fikoeritrin. Mayoritas hasil studi telah menunjukkan bahwa ekstrak maupun isolat aktif dari Kappaphycus alvarezii memiliki aktivitas farmakologi yang potensial seperti antioksidan, antibakteri, antiinflamasi, antikanker, antijamur, dan antidiabetes. Berbagai hasil studi tersebut menunjukkan potensi Kappaphycus alvarezii sebagai agen terapeutik sehingga berpotensi dikembangkan lebih lanjut dalam pengobatan alternatif dan komplementer.
Review: Sterilisasi Produk Farmasi Steril dengan Metode Through Flow Filtration dan Tangential Flow Filtration I Gede Yudistira Perdangga Bandem; Kadek Adisthi Pradipthasari; Kadek Indra Aryani; Ni Luh Dian Senja Pratiwi; Putu Siska Angelina Pramesti; I Gusti Ngurah Agung Dewantara Putra
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 5 (2025): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i5.1675

Abstract

The production of pharmaceutical sterile products requires strict procedures to minimize the risk of microbial, particulate and pyrogen contamination that can be harmful to the user's health. The selection of the right sterilization method is the key to achieving the desired stability of the final product. Filtration sterilization is one of the oldest methods used for pharmaceutical sterile products. There are two types of feed flow in the method, namely through flow filtration and tangential flow filtration. This review article is prepared through literature search and download of national or international journals with inclusion or exclusion criteria that have been set. Literature sources are accessed online from various sites such as Google Scholar and Pubmed in the range of 2014-2024. The keywords used for journal searches are sterilization, through flow filtration, and tangential flow filtration. This review article reviews and compares the two methods to understand the differences, mechanism of action, and research objectives based on the review article on membrane filtration sterilization. This review aims to provide a better insight into the advantages and disadvantages of each membrane filtration sterilization method, as well as guidance in choosing the appropriate method based on the characteristics of the product to be sterilized. The results showed that through flow filtration is more commonly used in small volume and batch processes because of its simple design, but has limitations in reducing membrane fouling. In contrast, tangential flow filtration allows for continuous processing of larger volumes, with the advantage of minimizing particle build-up on the membrane surface, thus extending membrane life. The choice of method is also influenced by factors such as particle size, viscosity of the solution, sensitivity to heat, as well as operating costs. An in-depth understanding of the Working Principle and application of each method is essential for the pharmaceutical industry to ensure the quality, safety and efficiency of the production process. Thus, this review is expected to be a reference for researchers and practitioners in determining the optimal filtration sterilization strategy according to product needs.
Co-Authors Anak Agung Gede Rai Yadnya Putra I Gede Yudistira Perdangga Bandem I Gusti Ngurah Agung Dewantara Putra Kadek Adisthi Pradipthasari Kadek Indra Aryani Ni Luh Dian Senja Pratiwi Putu Oka Samirana