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All Journal Prosiding Workshop dan Seminar Nasional Farmasi (WSNF) Jurnal Praba: Jurnal Rumpun Kesehatan Umum
Desak Nandini Prameswari Pagedongan
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

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Analisis Bibliometrik Penelitian Influenza menggunakan VOSviewer Putu Meisa Cahyana; Gede Hada Satria Wibawa Putra Arnatha; Putu Ristanaya Maurayanti; Kadek Risa Apriani; Ida Ayu Sitha Cahyani; Ni Kadek Sri Adnyani Alit Putri; Putu Alin Michelle Arisanti; Desak Nandini Prameswari Pagedongan; Rahma Jeanyfer Gita Natih
Prosiding Workshop dan Seminar Nasional Farmasi Vol. 3 (2024): Prosiding Workshop dan Seminar Nasional Farmasi 2024
Publisher : Program Studi Farmasi Fakultas MIPA Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/WSNF.2024.v03.p43

Abstract

Influenza merupakan penyakit pernafasan akut yang telah menjadi wabah dan epidemi di seluruh dunia. Karena influenza telah menjadi perhatian besar di bidang kesehatan, mendorong para peneliti untuk melakukan penelitian dan mempublikasikannya di berbagai media massa, termasuk jurnal. Penelitian ini bertujuan untuk mengeksplorasi tren dan sebaran penelitian terkait influenza, memberikan gambaran jelas mengenai topik yang dibahas, jenis publikasi, asal negara peneliti, jurnal tempat hasil penelitian tersebut diterbitkan, serta bahasa dalam analisis bibliometrik. Untuk memperoleh informasi mengenai penelitian Influenza digunakan kata kunci influenza dengan database Google Scholar. Sebagai acuan penggalian hasil pencarian, digunakan area topik berdasarkan kata kunci, judul dan kriteria abstrak yang berkaitan dengan penelitian influenza. Ekstraksi hasil pencarian dilakukan menggunakan VOSviewer. Ditemukan total 44 artikel dengan tipe data Artikel Jurnal dalam range tahun publikasi 2014 hingga 2021. Publikasi tentang influenza menjadi tren dari tahun ke tahun, mengingat influenza dapat terjadi setiap tahunnya. Sementara itu, kata kunci yang paling sering dibicarakan yaitu influenza, vaksinasi, virus influenza, pandemi, dan vaksin. Penggunaan VOSviewer dapat menganalisis jumlah artikel yang telah diterbitkan tentang influenza, hubungan antara influenza dan vaksinasi, dan menawarkan pengamatan penting mengenai tren penelitian yang muncul dan wawasan terkini.
Efektivitas Terapi Kombinasi Metformin dan Glimepiride pada Pasien Diabetes Mellitus Tipe 2 : Tinjauan Literatur Desak Nandini Prameswari Pagedongan; Ketut Widyani Astuti
Jurnal Praba : Jurnal Rumpun Kesehatan Umum Vol. 3 No. 3 (2025): September : Jurnal Praba : Jurnal Rumpun Kesehatan Umum
Publisher : STIKES Columbia Asia Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62027/praba.v3i3.493

Abstract

Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disease characterized by hyperglycemia due to insulin resistance, decreased insulin secretion, or a combination of both. The burden of this disease continues to increase globally, making effective, safe, and affordable management an urgent need. One widely used therapeutic strategy is the fixed-dose combination (FDC) of metformin and glimepiride. This combination is considered beneficial because the two drugs complement each other in their mechanisms of action: metformin reduces hepatic glucose production and increases insulin sensitivity, while glimepiride stimulates insulin secretion from pancreatic β-cells. Furthermore, the use of FDC can simplify the treatment regimen, thereby improving patient adherence to long-term therapy. Article searches were conducted through Google Scholar and PubMed with the keywords "((Metformin) AND (Glimepiride)) AND (T2DM) AND (Fixed Dose Combination)", covering publications from 2020–2025 in both English and Indonesian. Of the total articles found, 15 studies met the inclusion criteria for further analysis. The review results showed that the use of metformin–glimepiride FDC was able to reduce HbA1c levels between 0.33% and 2.45%, reducing fasting plasma glucose (FPG) levels by 32–65 mg/dL, and postprandial plasma glucose (PPG) by 38–103 mg/dL. Most studies reported achieving glycemic targets as recommended by the American Diabetes Association (ADA). The most commonly reported side effects were mild hypoglycemia with an incidence of 4.8%–34.5% and gastrointestinal disturbances, but the overall safety profile of this combination was still acceptable. In terms of cost, FDC was considered more economical than the use of separate single drugs. Thus, metformin–glimepiride FDC was proven to be effective, relatively safe, and affordable in glycemic control in T2DM patients, especially in countries with limited resources. These findings support its use as a primary choice in clinical practice.
Co-Authors Gede Hada Satria Wibawa Putra Arnatha Ida Ayu Sitha Cahyani Kadek Risa Apriani Ketut Widyani Astuti Ni Kadek Sri Adnyani Alit Putri Putu Alin Michelle Arisanti Putu Meisa Cahyana Putu Ristanaya Maurayanti Rahma Jeanyfer Gita Natih