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All Journal Farmaka Jurnal Medika Farmaka
Asherlia, Dwita
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Artikel Review: Tanaman yang Memiliki Potensi sebagai Antikanker Payudara Isybillah Ahmad, Afifah; Sulaeman, Agus; Suri Darmawan, Ammar; Yayuk Febriyanthi , Anggita; Novia Adiningsih, Arum; Malik Al Akbar, Ayatullah; Akbar Rulazi, Bagus; Larson Boling Sau, Barth; Adinda, Deistha; Eka Cahyani, Dhiana; Yunita, Dilla; Asherlia, Dwita; Ernawati, Ernawati; Hossanti Ntobu, Febri
Jurnal Medika Farmaka Vol 3 No 1 (2025): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v3i1.58

Abstract

Introduction: This study examines the role of pharmacotherapy in immune system diseases and cancer, highlighting the potential of natural compounds as anticancer agents. This study reviews various studies using in silico, in vitro, and in vivo approaches to activate the anticancer activity of various plant extracts and bioactive compounds. Method: This article review uses references obtained from database searches with online search instruments published nationally and internationally. Result: The results of the analysis showed that natural compounds contribute to the inhibition of cancer cell growth through apoptosis mechanisms, antioxidant activity, and reduction of inflammation. Various molecular pathways such as HER2, survivin, EGFR, Nrf2-Keap1, and PI3K/AKT/mTOR are the main targets in the development of natural compound-based therapies. The evidence collected shows that natural compounds have great potential as safer and more effective innovative cancer therapies. Conclusion: 13 plants were found to have the potential as anticancer agents in breast cancer therapy, with mechanisms of action including apoptosis induction, inhibition of cancer cell proliferation, modulation of the immune system, and regulation of molecular signaling pathways.
REVIEW JURNAL: FORMULASI DAN EVALUASI SEDIAAN GRANUL BAHAN ALAM Asherlia, Dwita; Lian, Kevin Efraim; Kiik, Rosa Virginia; Kasihtheisya, Naida; Pahlevi, Muhamad Reza; Pratama, Reza
Farmaka Vol 22, No 3 (2024): Farmaka (November)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v22i3.56226

Abstract

Bahan alam merupakan bahan dari alam baik yang mengalami proses pengolahan ataupun tidak dengan untuk tujuan kesehatan, sumber alam yang digunakan bisa didapatkan dari tumbuhan, hewan, maupun mineral. Berdasarkan survey yang dilakukan oleh WHO diketahui bahwa sebesar 88% bahan alam digunakan sebagai obat. Sedangkan, di Indonesia menurut survey data Riskesdas, bahan alam yang digunakan sebagai obat pada tahun 2018 sebesar 48%. Bahan alam yang digunakan biasanya diolah menjadi produk granul. Review jurnal dilakukan dengan mengumpulkan beberapa sumber data primer yaitu artikel jurnal pada situs resmi PubMed dan Sinta. Formulasi yang banyak digunakan untuk membuat granul yaitu granulasi basah dan granulasi kering yang diformulasikan dengan penambahan bahan eksipien berupa pengisi, pemanis, pengikat, penghancur, pelicin (glidant, lubrikan dan antiadherent). Evaluasi yang dilakukan diantaranya uji kelembaban, organoleptik, laju alir, sudut istirahat, densitas dan kompresibilitas, distribusi ukuran partikel, uji disolusi, uji pH, uji volume tuang, uji volume guncang, uji waktu dispersi, uji kerapuhan, uji porositas, uji waktu larut, uji susut pengeringan granul, indeks kompresibilitas dan rasio Hausner.
Co-Authors Adinda, Deistha Agus Sulaeman Akbar Rulazi, Bagus Eka Cahyani, Dhiana Ernawati Ernawati Hossanti Ntobu, Febri Isybillah Ahmad, Afifah Kasihtheisya, Naida Kiik, Rosa Virginia Larson Boling Sau, Barth Lian, Kevin Efraim Malik Al Akbar, Ayatullah Novia Adiningsih, Arum Pahlevi, Muhamad Reza Pratama, Reza Suri Darmawan, Ammar Yayuk Febriyanthi , Anggita Yunita, Dilla