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All Journal Farmaka Jurnal Medika Farmaka
Kasihtheisya, Naida
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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A Review : Pengembangan Obat Rheumatoid Arthritis (RA) dengan Berbagai Pendekatan Amelia, Ferda; Kaniawati, Marita; Gabriela Da Costa Soares, Fidelia s; Languwila, Indrawati; Dwi Fatma, Ira; Jefry, Jefry; Efraim Lian, Kevin; Irene Welmince Bokotei, Martini; Taofiq Putra Pratama, Muhamad; Septri Rahmawati, Nabila; Kasihtheisya, Naida; Subakti, Nanda; Dodit Rinaldi, Muhammad
Jurnal Medika Farmaka Vol 3 No 1 (2025): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v3i1.59

Abstract

Introduction: Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints, which can lead to cartilage damage and disability. Not all standard medications for RA therapy are efficient for all patients and long-term use can cause serious side effects. Therefore, it is necessary to develop drugs for RA involving various approaches, both pharmacological and non-pharmacological. Method: This article review is based on references to several articles from online databases published nationally and internationally. Result: From the article search, there were 10 articles discussing RA drug development from various approaches. Conclusion: Based on the review of articles carried out, there is drug development using a pharmacological approach including the use of natural ingredients such as purslane tea, red betel leaf extract, secang plants and curcumin, nanotechnology-based innovations such as composite hydrogel and MTX nanocarriers, a drug repurposing approach to the discovery of new drugs alpha-linolenic acid and Belatacept as well as non-pharmacological approaches with complementary therapies such as red ginger and warm betel compresses. Keywords: Drug development, treatment, rheumatoid arthritis
REVIEW JURNAL: FORMULASI DAN EVALUASI SEDIAAN GRANUL BAHAN ALAM Asherlia, Dwita; Lian, Kevin Efraim; Kiik, Rosa Virginia; Kasihtheisya, Naida; Pahlevi, Muhamad Reza; Pratama, Reza
Farmaka Vol 22, No 3 (2024): Farmaka (November)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v22i3.56226

Abstract

Bahan alam merupakan bahan dari alam baik yang mengalami proses pengolahan ataupun tidak dengan untuk tujuan kesehatan, sumber alam yang digunakan bisa didapatkan dari tumbuhan, hewan, maupun mineral. Berdasarkan survey yang dilakukan oleh WHO diketahui bahwa sebesar 88% bahan alam digunakan sebagai obat. Sedangkan, di Indonesia menurut survey data Riskesdas, bahan alam yang digunakan sebagai obat pada tahun 2018 sebesar 48%. Bahan alam yang digunakan biasanya diolah menjadi produk granul. Review jurnal dilakukan dengan mengumpulkan beberapa sumber data primer yaitu artikel jurnal pada situs resmi PubMed dan Sinta. Formulasi yang banyak digunakan untuk membuat granul yaitu granulasi basah dan granulasi kering yang diformulasikan dengan penambahan bahan eksipien berupa pengisi, pemanis, pengikat, penghancur, pelicin (glidant, lubrikan dan antiadherent). Evaluasi yang dilakukan diantaranya uji kelembaban, organoleptik, laju alir, sudut istirahat, densitas dan kompresibilitas, distribusi ukuran partikel, uji disolusi, uji pH, uji volume tuang, uji volume guncang, uji waktu dispersi, uji kerapuhan, uji porositas, uji waktu larut, uji susut pengeringan granul, indeks kompresibilitas dan rasio Hausner.
Co-Authors Amelia, Ferda Asherlia, Dwita Dodit Rinaldi, Muhammad Dwi Fatma, Ira Efraim Lian, Kevin Gabriela Da Costa Soares, Fidelia s Irene Welmince Bokotei, Martini Jefry Jefry Kiik, Rosa Virginia Languwila, Indrawati Lian, Kevin Efraim Marita Kaniawati Pahlevi, Muhamad Reza Pratama, Reza Septri Rahmawati, Nabila Subakti, Nanda Taofiq Putra Pratama, Muhamad