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All Journal Jurnal Medika Farmaka
Dila Ayu Apsari, Ratna
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology

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Review: Potensi Spesies Croton Sebagai Anti-HIV Hanifah, Nidaa; Dila Ayu Apsari, Ratna; Anis Jungjunan, Repita; Muhammad Wahid Fadhilah, Reyhan; Virginia Kiik, Rosa; Oktapiani, Selvia; Maria Ina Ose Tapowolo, Selviana; Musdalifah, Siti; Pudjiastuty, Tiara; Septiani, Yuni
Jurnal Medika Farmaka Vol 3 No 1 (2025): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v3i1.60

Abstract

Introduction: HIV is a retrovirus that attacks the immune system and can develop into AIDS if not treated. Drug resistance and therapy limitations are major challenges. The genus Croton (Euphorbiaceae) has potential as a source of anti-HIV compounds, with species such as C. megalocarpus, C. dichogamus, and C. oligandrus capable of inhibiting reverse transcriptase and reactivating latent viruses. Methods: This narrative review, analyzes the literature from 2020–2024. Results: Studies show that bioactive compounds from Croton, particularly diterpenoids and flavonoids, have anti-HIV activity through the inhibition of reverse transcriptase and reactivation of latent viruses. Conclusion: The genus Croton has the potential to be a new source of anti-HIV drugs. With the increasing drug resistance, the development of bioactive compounds from Croton could become a promising therapeutic alternative.Keywords: Croton, anti-VIV, natural compound
Co-Authors Anis Jungjunan, Repita Hanifah, Nidaa Maria Ina Ose Tapowolo, Selviana Muhammad Wahid Fadhilah, Reyhan Musdalifah, Siti Oktapiani, Selvia Pudjiastuty, Tiara Septiani, Yuni Virginia Kiik, Rosa