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All Journal Jurnal Pendidikan Kimia (JPKim) Pharmaceutical Sciences and Research (PSR)
Ramadiani, Dwi Liza
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Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science

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Oxidized cellulose 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) for Mn(II) adsorption Mahendra, I Putu; Finaritan, Venti; Ramadiani, Dwi Liza; Harianja, Hiskia; Pasaribu, Khatarina Meldawati
Jurnal Pendidikan Kimia Vol. 16 No. 3 (2024): J. Pendidik. Kim : December 2024
Publisher : Pascasarjana Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jpkim.v16i3.65195

Abstract

The presence of excess Mn²⁺ in water can result in unpleasant odors and tastes, and its consumption can lead to neurological disorders in humans. Adsorption using oxidized cellulose is an efficient method for removing Mn²⁺ ions. In this study, cellulose was oxidized using the TEMPO/NaOCl/NaBr system with varying NaOCl concentrations (5, 15, and 30 mmol/g) to identify the optimum conditions for Mn²⁺ adsorption. The carboxyl group content in the oxidized cellulose samples was 0.2393, 0.2435, and 0.2664 mmol/g, respectively. The adsorption efficiencies were 92.40%, 91.71%, and 91.43%, with the highest efficiency observed at 5 mmol/g NaOCl. The decrease in adsorption efficiency at higher NaOCl concentrations was attributed to the oxidation of secondary hydroxyl groups, forming undesirable ketone groups and disrupting the reaction pathway. FTIR analysis confirmed successful oxidation with a new absorption band at 1646 cm⁻¹. XRD analysis showed an increase in the crystalline index to 82.8%, 83.1%, and 83.13% for NaOCl concentrations of 5, 15, and 30 mmol/g, respectively. This study highlights the potential of TEMPO/NaOCl/NaBr-oxidized cellulose as an effective adsorbent for Mn²⁺ removal under optimized conditions.
Isolation, Structural Characterization, and In Vitro Bioactivity Assessment of Extracellular Vesicles Derived from Lacticaseibacillus paracasei Ramadiani, Dwi Liza; Rahmasari, Ratika; Wahyuni, Tri; Kusmiati, Kusmiati; Irawan, Herman; Pasaribu, Khatarina Meldawati
Pharmaceutical Sciences and Research Vol. 13, No. 2
Publisher : UI Scholars Hub

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Abstract

The field of study on extracellular vesicles (EVs) has recently focused on probiotic bacteria, due to their ability to exhibit a wide variety of biological activity. Therefore, this study aims to evaluate the effect of nutrient modulation during Lacticaseibacillus paracasei cultivation on EVs production and bioactivity. EVs were isolated by ultrafiltration method and were characterized using NTA and cryo-TEM. An in vitro evaluation was used to assess the bioactivities, antioxidant properties, anti-inflammatory potential, and ability to inhibit α-glucosidase activity. The results showed that the 2 LPEV exhibited the characteristics of vesicles with size of 96.04–100.29 nm. Cultivation in 50% MRS increased the number of particles (5.70 × 10⁹ particles/mL) compared with 100% MRS (4.46 × 10⁹ particles/mL). In addition, LPEV exhibited moderate antioxidant activity (15.5–34.6%), strong anti-inflammatory activity (90.6–99.2%), and substantial α-glucosidase inhibitory activity (75.5–79.7%). The reducing nutrients increased EV production without changing their physical and chemical properties or biological activity. This suggest that changing nutrients is an easy way to increase L. paracasei EV production and use LPEVs in the future for biomedical studies.
Co-Authors Finaritan, Venti Harianja, Hiskia I Putu Mahendra Irawan, Herman Kusmiati Kusmiati Pasaribu, Khatarina Meldawati Rahmasari, Ratika tri wahyuni