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All Journal Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Biology, Medicine, & Natural Product Chemistry
Nafisah, Raihana Frika
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Formulation and Characterization Tests of SCOBY Kombucha Gel Agustina, Eva; Nafisah, Raihana Frika; Fiddaroini, Achmad Farchan; Tania, Clarista Eka; Purnamasari, Risa; Andiarna, Funsu; Hidayati, Irul
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.143-151

Abstract

The wound is the damage to body tissues caused by various factors such as accidents, sharp object scratches, etc. Proper care is necessary to accelerate the wound healing process. Topical medications, such as gel preparations, are commonly used for wounds. Kombucha SCOBY is believed to contain bioactive compounds that can accelerate the wound healing process, making it a potential active ingredient in gel preparations. This research aims to determine the characteristics of kombucha SCOBY gel with various concentration variations. SCOBY is obtained from kombucha fermentation using green tea, sugar, and kombucha culture. Preparing kombucha SCOBY gel involves using carbomer 940, methyl paraben, triethanolamine, glycerin, and SCOBY kombucha. The concentration variations of kombucha SCOBY gel include 0%, 2%, 4%, 8%, 10%, and 12%. Each formula undergoes physical characteristic tests including an organoleptic test, hedonic test, homogeneity test, pH test, spreadability test, and adhesiveness test. Data obtained after physical characteristic tests of the gel preparations are analyzed descriptively. Based on the conducted research, it was found that kombucha SCOBY gel preparations with concentration variations of 0%, 2%, 4%, 8%, 10%, and 12% exhibited different characteristics. The higher the gel concentration, the more acidic the gel's aroma, the more liquid the texture, and the more intense the color. SCOBY added to the gel preparation can increase the pH value, adhesiveness, and spreadability of the gel.
Effectiveness and Role of Symbiotic Culture of Bacteria and Yeast (SCOBY) Kombucha Gel on Incisional Wound Healing in Mice (Mus musculus) Nafisah, Raihana Frika; Agustina, Eva; Purnamasari, Risa; Andiarna, Funsu; Hidayati, Irul
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 10, No 3 (2025): October 2025
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v10i3.11282

Abstract

Incision wounds are common occurrences in daily life, and appropriate wound management is essential to promote and accelerate the healing process. Wound care can be performed using topical preparations such as gels containing bioactive compounds. SCOBY kombucha is believed to contain bioactive compounds, such as compounds from green tea (especially polyphenols) and metabolites produced by microbes (organic acids, alcohols, vitamins, etc.) The aim of this research is to determine the effectiveness of SCOBY kombucha gel on the healing of incision wounds in mice (Mus musculus). The method used in this research is a Completely Randomized Design (CRD) with 8 treatment groups, including 2 control groups and 6 test groups. The concentrations of SCOBY kombucha gel used are 0%, 2%, 4%, 8%, 10%, and 12%. The SCOBY kombucha gel is applied twice daily until the wound closes. Observation of the incision wound is carried out by measuring the length of the wound that has not yet closed. Based on the conducted research, it was found that SCOBY kombucha gel is effective in healing incision wounds as evidenced by the reduction in wound size due to the bioactive compounds in SCOBY. The most significant wound healing effect was observed with the 12% SCOBY kombucha gel, as there was a significant difference compared to the negative control group, 0%, 2%, 4%, and 8% SCOBY kombucha gels.
Co-Authors Eva Agustina, Eva Fiddaroini, Achmad Farchan Funsu Andiarna Irul Hidayati Risa Purnamasari Tania, Clarista Eka