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Effect of Extract Meat Dates (Phoenix Dactylifera L.) to Oxytocin Levels in Pregnant Mice (Mus Musculus L.) Agustina, Eva; Purnamasari, Risa; Lusiana, Nova
Health Notions Vol 1 No 2 (2017): April-June 2017
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (150.835 KB)

Abstract

The process of spontaneous labor is sensitive to the oxytocin hormone that causes uterine smooth muscle contraction as a receptor for the start of labor. Dates contains source of carbohydrates are simple sugars, iron, potassium, selenium, calcium, and flavonoids. The purpose of this study was to determine the effect of date’s extracts (Phoenix dactilifera L) to the oxytocin hormone day 19 of gestation age of mice (Mus musculus L). This experiment devide dose of date extract into four groups, group I : control (no treatment), group II: 3 dates (3.12 mg/kg), group III 5 dates (5.2 mg/kg), and group IV 7 dates (7.28 mg/kg) to the oxytocin hormone. The research method is done by extracting palm ajwa with methanol. Treat made orally at the age of 14-19 days gestation. Measurement of oxytocin levels using ELISA at the age of pregnancy 19 days, showed the average number of levels of the oxytocin hormone in group I in the amount of 126.494 ng / L, the second group is equal to 124.169 ng / L, group III amounting to 129.041 ng / L, and group IV is equal to 132.252 ng / L. Overall extract dates with various doses of the treatment led to increased levels of the oxytocin hormone in mice. However, these increases did not show a significant effect, although the hormones oxytocin on uterine tissue of mice kept rising.
Antioxidant And Antibacterial Activities Of Methanol Extract Of Fig Fruit And Leaves (Ficus Carica L.) Agustina, Eva; Lusiana, Nova; Purnamasari, Risa; Faidah, Nurul Ilmi; Agustin, Azlinda Mitha
Journal of Islamic Medicine Vol 5, No 1 (2021): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2021
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v5i1.11376

Abstract

Background: Fig plants (Ficus carica L.) have phytochemical contents such as polyphenols, flavonoids, and anthocyanins which are relatively high. The content of this active compound can be used as an antioxidant and antibacterial. Objectif: The study aims to determine the antioxidant and antibacterial activity of methanol extracts fruit and leaves of fig (Ficus carica L.). Methods : DPPH method was carried out to determine the antioxidant fruit and leaves of fig (Ficus carica L.) by observing the change in colour of the test sample after incubation with DPPH solution using a UV-Vis spectrophotometer at a wavelength of 517 nm. The antibacterial test uses disc paper diffusion test to see the inhibition zone formed and continued with the MIC and MKC tests. Results : The antioxidant test results showed the IC50 values in methanol extracts of fig fruits were 13.402 ppm and 7.9875 ppm for fig leaves. From the IC50 value, both the fruit and fig leaves are classified into a solid antioxidant compound. The antibacterial test results showed that the highest inhibitory diameter was found at a 100% concentration of 28.5 mm. The quantitative antibacterial activity test showed that the methanol extract of fig fruit had a MIC value at a concentration of 80% and a MKC value at a concentration of 100%. The optimal strength as an antibacterial from fruit extracts and leaves is 100% concentration. Conclusion : The results showed the methanol extract of fig (Ficus carica L.) has potential as an antioxidant and antibacterial compound.Keyword : Antioxidant, Antibacterial , Fig Plants
The Effectiveness of Zinc Micronutrients From Pumpkin (Cucurbita moschata D) Extract on the Testosterone Levels of Mice (Mus musculus L) Risa Purnamasari; Nova Lusiana; Linda Prasetyaning Widayanti; Mei Lina Fitri Kumalasari
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17623

Abstract

Various factors cause disharmony in the household. One of them is erectile dysfunction. This can be treated by providing aphrodisiacs and some minerals such as zinc to increase libido. One of the plants that contain zinc is pumpkin (Cucurbita morchata D ). This study was conducted to determine the differences in giving pumpkin skin, meat, and seed extracts to testosterone levels. This study uses a laboratory experimental research type. This study, using extract variables from the skin, meat and seeds of pumpkin (Cucurbita moschata D) and levels of the hormone testosterone. The sample used was male mice (Mus musculus) divided into control groups and three treatment groups. Data were analyzed using the One-way ANOVA statistical test.There were differences in testosterone levels in mice between the control group and the group of mice given extracts of meat, skin and seeds (p-value <0.05).The highest testosterone level in mice was in mice given pumpkin seed extract.
Effect of Extract Meat Dates (Phoenix dactylifera L.) to Oxytocin Levels in Pregnant Mice (Mus musculus L.) Eva Agustina; Risa Purnamasari; Nova Lusiana
Health Notions Vol 1, No 2 (2017): April-June
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (150.835 KB) | DOI: 10.33846/hn.v1i2.19

Abstract

The process of spontaneous labor is sensitive to the oxytocin hormone that causes uterine smooth muscle contraction as a receptor for the start of labor. Dates contains source of carbohydrates are simple sugars, iron, potassium, selenium, calcium, and flavonoids. The purpose of this study was to determine the effect of date’s extracts (Phoenix dactilifera L) to the oxytocin hormone day 19 of gestation age of mice (Mus musculus L). This experiment devide dose of date extract into four groups, group I : control (no treatment), group II: 3 dates (3.12 mg/kg), group III 5 dates (5.2 mg/kg), and group IV 7 dates (7.28 mg/kg) to the oxytocin hormone. The research method is done by extracting palm ajwa with methanol. Treat made orally at the age of 14-19 days gestation. Measurement of oxytocin levels using ELISA at the age of pregnancy 19 days, showed the average number of levels of the oxytocin hormone in group I in the amount of 126.494 ng / L, the second group is equal to 124.169 ng / L, group III amounting to 129.041 ng / L, and group IV is equal to 132.252 ng / L. Overall extract dates with various doses of the treatment led to increased levels of the oxytocin hormone in mice. However, these increases did not show a significant effect, although the hormones oxytocin on uterine tissue of mice kept rising. Keywords: Dates extract, Oxitocin levels, Pregnant mice
Basal Body Temperature Difference Before and During The Endometrial Wall Decay on The Menstrual Cycle Ika Mustika; Nova Lusiana; Estri Kusumawati; Risa Purnamasari
Journal of Health Science and Prevention Vol. 2 No. 1 (2018): JHSP Vol 2 No 1 - 2018
Publisher : State Islamic University of Sunan Ampel

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (559.206 KB) | DOI: 10.29080/jhsp.v2i1.112

Abstract

The menstrual cycle is a complex process involving hormones and reproductive organs. Hormonal changes that occur in the menstrual cycle result in changes in body basal temperature in women. Basal body temperatures can identify phase changes in one menstrual cycle. This study is to determine whether there is influence of decay of the endometrium wall against the basal body temperature in adolescent girls. This research is observational analytic with cross sectional time approach. This study was conducted on 60 samples with the age of 19-22 years. Data used in this research are primary data that is basal body temperature measurement and questioner. The analysis in this study is paired sample t test test using SPSS 16. The results obtained significance value of 0.003 <0.05, so it can be concluded that there is influence of decay of the endometrium wall in the menstrual cycle against changes in basal body temperature. The endometrial wall decay on the menstrual cycle causes basal body temperature decreased compare with before the uterine lining decay or menstruation.
Efektivitas Tanaman Daun Tombak (Sagittaria lancifolia) dalam Fitoremediasi Linear Alkylbenzene Sulfonates (LAS) pada Media Air Salsa Nabila; Eva Agustina; Risa Purnamasari; Rony Irawanto
BIOMA: Jurnal Biologi dan Pembelajarannya Vol 5 No 1 (2023): BIOMA: Jurnal Biologi dan Pembelajarannya
Publisher : Universitas Sulawesi Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31605/bioma.v5i1.2489

Abstract

Pencemaran air merupakan masalah lingkungan yang serius yang mengancam kesehatan manusia dan lingkungan di seluruh dunia. Salah satu pencemar yang sering dijumpai dilingkungan adalah detergen. Adanya pencemaran air dapat mengancam kesehatan berbagai organisme termasuk manusia. Untuk itu, diperlukan solusi untuk menanggulangi permasalahan tersebut. Salah satu teknik yang dapat digunakan adalah dengan fitoremediasi menggunakan tanaman daun tombak (Sagittaria lancifolia). Tanaman ini terbukti mampu meyerap berbagai polutan yang ada di lingkungan. Oleh karena itu, penelitian ini bertujuan untuk mengetahui efektifitas tanaman daun tombak (Sagittaria lancifolia) dalam fitoremediasi detergen LAS (Linear Alkylbenzene Sulfonates) pada media air. Metode yang digunakan adalah eksperimental dengan Rancangan Acak Lengkap (RAL) dengan empat perlakuan berbeda konsentrasi LAS, yaitu 0 mg/L, 10 mg/L, 30 mg/L, dan 50 mg/L. Hasil penelitian menunjukkan tanaman daun tombak (Sagittaria lancifolia) efektif dalam menyerap kandungan LAS (Linear Alkylbenzene Sulfonates) dalam air dengan daya penyisihan polutan paling tinggi sebesar 95% pada air yang tercemar LAS 10 mg/L. Nilai pH dan TDS mengalami peningkatan tiap minggu pada tiap konsentrasi dan kadar COD meningkat tiap konsentrasi seiring dengan peningkatan kandungan LAS. Namun, hasil pengukuran ketiga parameter masih sesuai dan tidak melebihi ambang batas baku mutu yang telah ditetapkan sehingga dapat dikatakan tanaman sagitaria lancifolia dapat menstabilakan kualitas air yang tercemar LAS.
The Impact of Immunity on Developing Literacy Culture at Primary School: Investigating Students’ Extroverted and Introverted Personalities Evi Fatimatur Rusydiyah; Misbakhul Munir; Hernik Farisia; Hanik Faizah; Risa Purnamasari
Journal of Innovation in Educational and Cultural Research Vol 4, No 2 (2023)
Publisher : Yayasan Keluarga Guru Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46843/jiecr.v4i2.542

Abstract

The development of literary culture in schools needs a literate ecosystem and full support from literacy activists in schools. This study aims to describe and explore the profile of literacy activists in madrasahs in terms of their level of immunity and personality traits. This study investigates the effect of student immunity as literacy activists in madrasahs with extroverted and introverted personality types on the ability to develop a literary culture. The parameters used to investigate the immunity levels in extroverted and introverted students were by examining the number of leukocytes, types of leukocytes, and the results of the IL-6 examination using the ELISA method. The results show that extroverted students have higher immunity than introverted students. The average leukocyte level of extroverted students is 24,350 cells/mm3 and introverted students is 50 cells/mm3. Meanwhile, the results of the IL-6 examination show the highest is 163,863 and the lowest is 43,984. Extroverted students can design various literacy programs that are challenging for students and are better able to build networks in developing literacy programs compared to introverted students. So, it can be concluded that extroverted students have a higher level of immunity, and also have the ability to explore and develop literacy programs better than introverted students.
Determining the Effect of Orange Peel Extract in Water on Total Cholesterol Fluctuations in HFD-Induced Mice Ria Qadariah Arief; Linda Prasetyaning W; Risa Purnamasari; Sarita Oktorina; Sri Hidayati L
Journal of Health Science and Prevention Vol. 7 No. 2 (2023): JHSP vol 7 No 2 - 2023
Publisher : State Islamic University of Sunan Ampel

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29080/jhsp.v7i2.1079

Abstract

Hypercholesterolemia, characterized by elevated levels of total cholesterol, is a well-established risk factor for cardiovascular diseases, necessitating the exploration of natural interventions to mitigate dyslipidemia and its associated health risks. This study aimed to investigate the potential influence of orange peel extract in water on total cholesterol fluctuations in HFD-induced mice. This study used a true experimental design to investigate the effects of dietary interventions on total cholesterol levels in a female mice model. A total of 18 adult mice were utilized for this research, and they were divided into three distinct groups. The allocation of mice into these groups was as follows: Control Group (n=6): The first group served as the control and received only Aquades (sterile water). High-Fat Diet (HFD) Group (n=6) as named HFD only: The second group consisted of mice that were exclusively fed a high-fat diet (HFD) for a total of 17 days. Orange Peel Extract Group (n=6): The third group, also exposed to the HFD for an initial 10-day period, was subsequently administered orange peel extract for seven days. The total cholesterol levels of the mice that were given orange peel extract decreased from 109 ± 7.43 mg/dL to 96.5 ± 10.07 mg/dL after the intervention. This decrease was statistically significant (p < 0.05). the risk of high total cholesterol levels in mice that were given orange peel extract was 33.3%, compared to 83.3% in mice that were given aquades and 50% in mice that were still on a high-fat diet (HFD). , the results of this study suggest that orange peel extract may offer a natural and accessible approach to address dyslipidemia and reduce the risk of cardiovascular diseases. While further research is needed to confirm these findings and explore their applicability to human health.
The Influence of Discovery Learning on Serotonin Hormones and Student Learning Achievements Husniyatus Salamah Zainiyati; Evi Fatimatur Rusydiyah; Hanik Faizah; Hernik Farisia; Risa Purnamasari; Qurrotul Ayun
Journal of Innovation in Educational and Cultural Research Vol 4, No 4 (2023)
Publisher : Yayasan Keluarga Guru Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46843/jiecr.v4i4.1186

Abstract

Discovery learning is a model designed to tackle the issue of low learning achievement. However, typically, research on discovery learning mainly focuses on outcomes to enhance specific abilities partially. Yet, discovery learning is also associated with physiological aspects. This study aims to determine the discovery of learning influence on learning achievement and serotonin. This is an experimental study. The independent variable (x) is discovery learning, whereas the dependent variables (y) are student achievement and serotonin. The statistical test used the paired sample t-test. Other data related to students' learning skills in the classroom using discovery learning were observed and analyzed with the descriptive qualitative method. There were significant differences in learning achievement and serotonin levels before and after the implementation of discovery learning.The average scores before and after the implementation of discovery learning were 46.75 and 78.55, respectively. The average hormone levels before and after the implementation of discovery learning were 719.25 and 1420.59 ng/mL, respectively. The implementation of discovery learning increases serotonin levels, thus optimizing student learning achievement. Following this research finding, research on how to increase serotonin levels through other learning methods needs to be conducted to explore many best practices that affect students' achievement.
Assessing the Tolerance of Sagittaria Lancifolia (Spear Plant) to Linear Alkylbenzene Sulfonates (LAS) Exposure Salsa Nabila; Risa Purnamasari; Eva Agustina; Rony Irawanto
Indonesian Journal of Biology Education Vol. 6 No. 1 (2023): INDONESIAN JOURNAL OF BIOLOGY EDUCATION
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

One of pollutant that commonly found in aquatic environment is detergent. Detergent pollution can cause skin irritation and other health problems in humans and animals that use contaminated water sources. To address this issue, it is critical to implement effective policies and regulations to control detergent pollution and promote sustainable wastewater management practices in Indonesia. One of the approaches to overcome detergent pollution is to use plants as pollutant absorbing agents, or commonly called phytoremediation techniques. Therefore, this study aims to determine the growth response of spear plant (Sagittaria lancifolia) in response to the stress of Linear Alkylbenzene Sulfonate (LAS) detergent. This research is an experimental research using a completely randomized design (CRD). There were four treatments tested with three replicates for each treatment. Treatment variations were based on the concentrations used in this study, namely 0 mg/L, 10 mg/L, 30 mg/L, and 50 mg/L. The research was conducted for four months, starting from July to October 2022, and was conducted in the greenhouse of Purwodadi Botanical Garden – BRIN. The result showed that although it experienced some morphological changes such as leaf drying, discoloration, and structural changes, Sagittaria lancifolia were able to survive and conduct metabolic activities properly during 28 days of Linear Alkylbenzene Sulfonates (LAS) pollutant stress.  Thus, Sagittaria lancifolia are able to be used as one of the strategies in restoring the aquatic environment polluted by domestic waste, including LAS detergent.