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All Journal Narra J JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Khosasi, Felix
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Comparative efficacy of solifenacin and tamsulosin in alleviating stent-related symptoms: A systematic review and meta-analysis Harahap, Dianita H.; Adhyatma, Kharisma P.; Elbert, Elbert; Khosasi, Felix; Warli, Muhammad H.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1683

Abstract

Ureteral stents, commonly used in urology, can cause side effects affecting patient quality of life. However, studies on managing lower urinary tract symptoms showed inconsistencies due to the use of various alpha-blockers and antimuscarinic drugs. The aim of this study was to evaluate the effectiveness of combining tamsulosin and solifenacin therapy compared to tamsulosin and solifenacin monotherapy for treating stent-related symptoms. Randomized controlled trials assessing tamsulosin, solifenacin, or their combination for stent-related symptoms treatment were identified through a comprehensive search of four databases (PubMed, Scopus, Web of Science, and Cochrane) from January 2018 to December 2023. Ureteral stent symptom questionnaire (USSQ), international prostate symptom score (IPSS), visual analog scale (VAS), and quality of life (QoL) were pooled for meta-analysis. Eleven studies with a total of 1,627 patients were included in the quantitative analysis. Solifenacin significantly improved urinary symptoms (MD: 15.31; 95%CI: 0.36–30.26; p=0.040) and reduced the IPSS (MD: -2.52; 95%CI: -3.68–-1.36; p<0.00001) compared to the control group. Tamsulosin reduced urinary symptoms on the USSQ (MD: 14.27; 95%CI: 8.68–19.86; p<0.00001), general health problems (MD: 4.53; 95%CI: 2.13­–6.94; p=0.0002), and IPSS (MD: -0.95; 95%CI: -1.86–-0.03; p<0.00001) compared to the control group. Solifenacin demonstrated a more significant reduction in the overall IPSS compared to tamsulosin (MD: -1.57; 95%CI: -2.85–-0.29; p=0.020). The combination of solifenacin and tamsulosin resulted in a significantly superior reduction in IPSS compared to solifenacin monotherapies (MD: -2.30; 95%CI: -3.23–-1.37; p<0.00001) and tamsulosin monotherapy (MD -3.17; 95%CI: -5.07­–-1.27; p=0.00001). No significant differences were found between tamsulosin and solifenacin in terms of QoL (MD: 0.12; 95%CI: -0.01–0.26; p=0.070) and VAS (MD: 0.25; 95%CI: -0.95–1.44; p=0.690). In conclusion, solifenacin was more effective than tamsulosin in reducing stent-related symptoms, and the combination of tamsulosin and solifenacin was superior to either monotherapy in alleviating stent-related symptoms.
IN VITRO EVALUATION OF PHYTOCHEMICAL COMPOUND FOR ANTIBACTERIAL ACTIVITY AT MURRAYA KOENIGII LEAF EXTRACT AGAINST THE GROWTH OF ESCHERICHIA COLI Elbert, Elbert; Adella, Cut Adeya; Faradina, Dwi; Lubis, Lokot Donna; Khosasi, Felix
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 11 No 1 (2024): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 11.1 (2024)
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v11i1.767

Abstract

Introduction: In developing nations, like Indonesia, urinary tract infection, or UTI, is a frequent infection in women that results from the growth of microorganisms in the urinary tract. Escherichia coli is the most common cause. Antibiotics are the major form of treatment; however, misuse of these drugs has led to resistance. Innovation in potential medical plants is crucial. The curry leaf plant (Murraya koenigii) is one of them. Methods: The agar diffusion method was used to assess antibacterial activity. Murraya koenigii leaves were gathered from a garden in Tanjong Morawa. Escherichia coli ATCC 25922 is the type of bacteria that is used. Using 96% ethanol as the solvent, Murraya koenigii leaves were extracted using the maceration method. There were six treatments with concentrations of 6.25%, 12.5%, 25%, and 50%, positive control levofloxacin, and negative control DMSO. Results: The results of the phytochemical screening of the extracts showed that metabolites like flavonoids, tannins, and triterpenes had antibacterial effects. Data on the diameter of the inhibition zone were examined using the Kruskal-Wallis statistical test. The findings demonstrated that all treatments had statistically significant differences (p<0.05). Discussions: The presence of compounds such as flavonoids, tannins, and triterpenes in curry leaf extract has an antibacterial effect on Escherichia coli. This compound can prevent the creation of nucleic acids, inhibit cell membrane function, damage the permeability of bacterial cells, and deactivate bacterial enzymes. Conclusion: The ethanol extract of curry leaves has an inhibitory effect on the growth of Escherichia coli bacteria.
IN VITRO EVALUATION OF THE ANTIBACTERIAL POTENTIAL OF PSIDIUM GUAJAVA LEAF EXTRACT AGAINST ESCHERICHIA COLI: UNCOVERING THE ROLE OF PHYTOCHEMICAL COMPOUNDS. Khosasi, Felix; Adella, Cut Adeya; Faradina, Dwi; Lubis, Lokot Donna; Elbert, Elbert
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 10 No 3 (2024): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 10.3 2024
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v10i3.765

Abstract

Introduction: Urinary tract infections (UTIs) are prevalent among women and are commonly caused by Escherichia coli. Although antibiotics are effective, their misuse contributes to rising antimicrobial resistance. Psidium guajava L., a traditional Indonesian medicinal plant, has shown promise as an alternative antibacterial agent. This study aimed to evaluate the inhibitory effect of P. guajava leaf extract against E. coli. Methods: Antibacterial activity was assessed using the agar diffusion method with E. coli ATCC 25922. Ethanolic extracts were obtained by maceration. Six treatment groups, including various concentrations of levofloxacin and dimethyl sulfoxide (DMSO), were tested to compare antibacterial effects. Results: Phytochemical screening revealed the presence of flavonoids, alkaloids, and tannins—compounds known for their antimicrobial activity. Inhibition zone diameters were measured and analysed using the Kruskal–Wallis one-way ANOVA. Discussion: The guava leaf extract demonstrated inhibitory activity against E. coli, likely due to its bioactive compounds. These constituents may exert antibacterial effects through disruption of nucleic acid synthesis, interference with membrane integrity, inhibition of energy metabolism, and prevention of biofilm formation. Conclusion: The ethanolic extract of Psidium guajava leaves exhibits significant antibacterial activity against Escherichia coli.
Co-Authors Adhyatma, Kharisma P. CUT ADEYA ADELLA, CUT ADEYA Dwi Faradina Elbert, Elbert Harahap, Dianita H. Lokot Donna Lubis, Lokot Donna Warli, Muhammad H.