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Hubungan Genotipe DNA Human Papillomavirus (HPV) terhadap Respons Terapi Radiasi pada Karsinoma Sel Skuamosa Serviks ADELLA, CUT ADEYA
Indonesian Journal of Cancer Vol 8, No 4 (2014): Oct - Dec 2014
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (688.318 KB)

The importance of human papilloma virus (HPV) infection in the outcome of cervical cancer after radiotherapy remains unknown. Our study explored whether the HPV status of tumors is associated with the outcome of radiotherapy in patients with cervical cancer. The biopsy cervix samples taken from 31 patients with squamous cell carcinoma cervix (Stage IIB-IIIB) that met in the inclusion criteria. The HPV were genotyping examination was conducted twice before and 3 month after radiation therapy. The subjects treated by radiation therapy according to standard procedures. After undergone complete radiation, response of radiation therapy was conducted by clinical assessment and repeat HPV genotyping test. A total of 31 patients had HPV-positive tumors in 83.37% (27 cases) of patients, with the details of a single infection of 75% and 9:37% multiple infections. Based on the type of HPV type 16 was obtained (43.74%), type 18 (18.64%). Persistent infection with HPV after radiation encountered by 34.61%. Complete clinical response observed in the single infection group number of 100%, while in the group of multiple infections by 33.3% (p = 0.115). While HPV infection settled with a complete clinical response by 32% (p = 0.346). There were no statistically relationships between clinical complete response with single or multiple HPV infection (p = 0.115). There were no statistically relationship between persistent HPV infection with complete clinical response. (p = 0.346)

IHC Expression Relationships MMP7 and VEGF With Normal Ovaries and Ovarian Pathologies Rusda, Muhammad; Rivany, Riza; Hasibuan, Citra Lestari; Lutan, Delfi; Aldiansyah, Dudy; Adella, Cut Adeya
Sumatera Medical Journal Vol. 2 No. 1 (2019): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

To investigate the association of MMP7 and VEGF expression with ovarian cancer, benign ovarian cysts, and normal ovaries. This study was analytical research with case-control design. In the study, IHC expression of MMP7 and VEGF was carried out on paraffin block of ovarian cancer tissue, benign ovarian cyst, and normal ovary. In 40 subjects with ovarian tumors, 17 patients were found with positive MMP7 expression. In the control group, no subjects were found with positive MMP7 expression. There was a significant relationship between MMP7 expression and ovarian tumor incidence. Meanwhile, in 40 subjects with ovarian tumors, 21 patients were found with positive VEGF expression. In the control group, no subjects with positive VEGF expression were found. There was a significant relationship between VEGF expression and ovarian tumor incidence. There was a significant relationship between MMP7 and VEGF expression with ovarian tumor incidence.

Effectiveness of education information concelling of knowledge women of age about cancer cancer and visual acetic acid inspection as early detection Cut, Adeya Adella; Sitohang, Nur Asnah
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 2 (2019): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Cervical cancer is cancer that occurs in the cervix , an area in the female reproductive organs which is the entrance to the uterus, located between the uterus and the intercourse or vagina. The main cause of cervical cancer is Human Papilloma Virus (HPV) infection. Cervical cancer usually attacks women aged 35-55 years. Visual Inspection with Acetic Acid (IVA) is a visual inspection of the cervix using vinegar with the eye to detect abnormalities after applying 3-5% vinegar. This community service aims to: (1) provide communication, education and information (IEC) about cervical cancer and the benefits of IVA Test, (2) conduct IVA Test, (3) measure the knowledge of women of childbearing age about cervical cancer and IVA test. Implemented at Klinik Bersalin Sari Medan (30 people). Data analysis using Wilcoxon test. The results of the activity obtained the majority of data aged 37-39 years (43.3%), Javanese (40%), Islamic religion (90%), first married age 21-23 years (43.3%), the number of births 3 times (30% ), the IVA test results are negative (90%), inflammation / cervicitis (10%). The knowledge before being given Information Education Communication (IEC) averaged = 14.57; SD = 3,633 and after being given IEC average = 23.60, SD = 1,589. Statistical test results obtained mean difference = 9.03 and P value = 0.001, it can be concluded that there is a significant influence of IEC on women of childbearing age knowledge about cervical cancer and IVA tests. It is recommended to midwives to socialize the benefits of IVA tests and carry them out as early detection of cervical cancer.

Efektivitas Konseling Informasi Edukasi Terhadap Pengetahuan Wanita Usia Subur Tentang Kanker Servik dan Inspeksi Visual Asam Asetat Sebagai Deteksi Dini Cut Adeya Adella; Nur Asnah Sitohang
Jurnal Riset Hesti Medan Vol 5, No 1 (2020)
Publisher : Akademi Keperawatan Kesdam I/Bukit Barisan Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34008/jurhesti.v5i1.182

Kanker serviks merupakan kanker yang terjadi pada serviks atau leher rahim, suatu daerah pada organ reproduksi wanita yang merupakan pintu masuk ke arah rahim, letaknya antara rahim (uterus) dan liang senggama atau vagina. Penyebab utama kanker leher rahim adalah infeksi Human Papilloma Virus (HPV). Kanker serviks biasanya menyerang wanita berusia 35-55 tahun. Inspeksi Visual dengan Asam Asetat (IVA) adalah pemeriksaan leher rahim secara visual menggunakan asam cuka dengan mata telanjang untuk mendeteksi abnormalitas setelah pengolesan asam cuka 3-5%. Pengabdian kepada masyarakat ini ini bertujuan:(1)memberikan komunikasi,edukasi dan informasi (KIE) tentang kanker serviks dan manfaat IVA Test;(2) melakukan IVA Test;(3) mengukur pengetahuan WUS tentang kanker serviks dan IVA test. Dilaksanakan di Klinik bersalin Sari Medan (30 orang). Anlisis data menggunakan Wilcoxon test. Hasil kegiatan diperoleh data mayoritas berusia 37-39 tahun (43.3%), suku Jawa (40 %), agama islam (90%), menikah pertama kali usia 21-23 tahun (43.3.%), jumlah melahirkan 3 kali (30%), hasil IVA Test WUS adalah negatif /serviks normal (90%), radang/servisitis (10%). Pengetahuan WUS sebelum diberi Komunikasi Edukasi Informasi (KIE) rata –rata = 14,57; SD =3.633 dan sesudah diberi KIE rata –rata= 23.60, SD = 1.589. Hasil uji statistik diperoleh beda mean = 9.03 dan nilai P=0,001, maka dapat disimpulkan ada pengaruh yang signifikan KIE terhadap pengetahuan WUS tentang kanker serviks dan tes IVA. Disarankan kepada bidan agar mensosialisasikan manfaat tes IVA dan melaksanakannya sebagai deteksi dini kanker serviks

PEMBERDAYAAN SISWA SEBAGAI KADER KESEHATAN DALAM PROGRAM EDUKASI KESEHATAN REPRODUKSI REMAJA DI SMP SWASTA MEDAN Nur Asnah Sitohang; Diah Lestari Nasution; Cut Adeya Adella
Jurnal Riset Hesti Medan Vol 3, No 2 (2018)
Publisher : Akademi Keperawatan Kesdam I/Bukit Barisan Medan

Adolescent reproductive and sexuality health in Indonesia is still low, this can be seen from the many cases of pregnancy out of wedlock, violence during courtship and abortion with high-risk drugs. The understanding of adolescents about reproductive health is the provision of adolescents in healthy and responsible behavior. But not all teenagers get information about reproductive health. This limitation of knowledge and understanding can bring teenagers towards risky behavior. This is a lack of information about sexuality and reproduction. Cadres health has a big role in realizing the optimal level of community health. Community service is carried out in two (2) junior high schools, namely Dharma Pancasila Private Junior High School (260 students and 21 cadres trained) and Al-Fhatiyan Private Middle School Medan (199 students and cadres trained by 16 students). The method used is by: 1. counseling with material on adolescent reproductive health; 2. cadre training; 3. Cadre mentoring. Evaluation of program success: pre test and post test cadres and student participants. Based on the results of the questionnaires distributed to students, the majority of data was 13 years old (47.5%), male sex (54%), high school parents education (62%) and entrepreneurial work (96.6%). The results of the dependent test obtained data, average knowledge before health education 26.23 and after health education39.58. The mean difference is 13,349 and the standard deviation is 3,911 and 95% CI 13,707-12,990. Based on the results of statistical tests obtained P = 0.001, it can be concluded that there is an influence of adolescent reproductive health cadres on student knowledge. For attitudes obtained data on average attitudes before counseling 27.57 and after counseling 39.58. The mean difference is 13,349 and the standard deviation is 3,802 and 95% CI 12,362 - 11,664. P value = 0.001 it can be concluded that there is an influence of adolescent reproductive health cadres on student attitudes. This PKM activity is useful in increasing knowledge and attitudes towards adolescent reproductive health. With increased knowledge of the behavior of adolescents to risky sexual behavior, and if the attitudes of adolescents towards sexual behavior are good, it is expected that sexually well and adolescents are expected to be responsible for their reproductive healthKeywords: cadres, education, health, reproduction, adolescents

Pendidikan Kesehatan Tentang Manajemen Kesehatan Menstruasi Terhadap Pengetahuan dan Sikap Remaja Madrasah Tsanawiyah Swasta Amal Saleh Nur Asnah Sitohang; Dewi Elizadiani Suza; Cut Adeya Adella
Jurnal Riset Hesti Medan Vol 5, No 2 (2020)
Publisher : Akademi Keperawatan Kesdam I/Bukit Barisan Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34008/jurhesti.v5i2.208

Menstruation is periodic bleeding occurring repeatedly every month in women that starts about 14 days after ovulation and is released through the vagina. Menstruation is a characteristic feature of a woman's maturity where there is a change in the uterus in preparation for pregnancy. Menstrual health management (MHM) is a term that is often used in relation to cleanliness during menstruation. Menstrual health management includes facilities used during menstruation including clean water, soap used for bathing and cleaning all parts of the body as well as cleaning sanitary napkins that have been used. MHM is also related to the access they have to safe and comfortable facilities to dispose of used sanitary napkins. Young women must understand knowledge about menstruation and how to manage it appropriately without shame or fear. Health education is a form of independent nursing action to help clients, both individuals, groups and communities in overcoming their health problems through learning activities in which the nurse acts as a nurse educator. This study aims to increase students' knowledge and attitudes about menstrual health management by providing health education. The method used was to socialize activities to the school, identify the condition of menstrual health service facilities in schools such as bathrooms, clean water supply, provide educational media for menstrual health management in the form of videos, leaflets and modules; conduct health education about menstrual health management and post tests. The data analysis used was univariate. The number of samples was 36 people, namely grade VII students. The results of the study that the majority of respondents were 12 years (77.8%), had menstruation (58.3%), age at first menstruation was 11 years (52.3%), experienced menstrual pain (66.7%), information sources regarding: (1) hygiene during menstruation is the mother (38.5%), (2) sanitary napkins from TV commercials (25%), menstruation from mothers (45.5%), (3) types of sanitary napkins currently used modern sanitary napkins (65.9%), (4) the current brand of sanitary napkins from mothers (36.5%). The majority of knowledge adolescents category is 88.9% good and the attitude of the adolescents is 100% positive. Research proves that there are still students with sufficient knowledge (10.1%) and considering the importance of MHM as an effort to prevent infection in the female reproductive system and minimize the occurrence of cervical cancer in women in the future. Researchers suggest that schools include this topic in subject matter so that reproductive health can be maintained.

DETEKSI DINI KANKER SERVIK PADA WANITA USIA SUBUR DENGAN INSPEKSI VISUAL ASAM ASETAT (IVA TEST) DI KLINIK BERSALIN KOTA MEDAN Diah Lestari Nasution; Nur Asnah Sitohang; Cut Adeya Adella
Jurnal Riset Hesti Medan Vol 3, No 2 (2018)
Publisher : Akademi Keperawatan Kesdam I/Bukit Barisan Medan

Cervical cancer in Indonesia ranks first, 65% of the patient's condition is in an advanced stage. In research in thirteen anatomical pathology laboratories in Indonesia, the frequency of cervical cancer patients was around 18.5%. This community service aims to: (1) provide communication, education and information (IEC) about cervical cancer and the benefits of IVA Test; (2) conduct IVA Test; (3) measure WUS's knowledge about cervical cancer and IVA test. Performed at the maternity clinic, namely SAM maternity clinic (20 people) and Sari (20 people). Data analysis using dependent t test. The results of the activity were data from 26-30 years old (40%), Batak tribes (13%), Islamic religion (95%), first marriage (77.5%), high school / diploma / undergraduate education (80%), IRT (77.5 %), the work of husband's employee (52.5%), first age married 26-30 years (40%) and not smoking (80%); using injection contraception (42.5%); the obstetric history of the majority of WUS giving birth twice (42.5%) , never checked (80%), no brother is sick (75%), breast cancer (10%), not much vaginal discharge (65%), no pain under the abdomen (70%), no bleeding during intercourse (90%) and did not experience irregular menstruation (55%); results of IVA WUS Test were negative (80%), inflammation (17.5) and positive (2.5); WUS knowledge before being given Information Education Communication (IEC) about cervical cancer and the IVA Test averages = 13.58, SD = 3.012 and after being given health education on average = 14.30, SD = 3.275. The results of statistical tests obtained different mean = 0.725 and P value = 0.016, it can be concluded that there was a significant effect of IEC on WUS knowledge about cervical cancer and IVA Test. Keywords: Cervical cancer, fertile age women (WUS), IVA Test

Pengaruh Pendidikan Kesehatan Terhadap Pengetahuan dan Sikap Siswa SMP Dharma Pancasila Tentang Manajemen Kesehatan Menstruasi Nur Asnah Sitohang; Cut Adeya Adella
Jurnal Riset Hesti Medan Vol 4, No 2 (2019)
Publisher : Akademi Keperawatan Kesdam I/Bukit Barisan Medan

Menstrual Hygiene Management (MHM) is the management of hygiene and health when women experience menstruation. The main problem in adolescents related to menstruation is the lack of knowledge about MSM and poor water sanitation. Many girls don't have the right understanding that menstruation is a normal biological process. Community service aims to improve students' knowledge and attitudes about menstrual health management. The method used is socializing; identify the state of menstrual health service facilities in schools: bathrooms, water, information; carry out bathroom renovations; provide educational media about menstrual health management in the form of posters, videos, leaflets, modules and flip sheets. Pre-test and post-test aims to identify students' knowledge and attitudes about menstrual health management. Analysis of the data used is the dependent t test. The knowledge of students before being given health education majority was in the sufficient category and thereafter increased to good. Likewise, students' attitudes increase to be positive. The statistical test results obtained mean difference of 7.72 and P Value = 0.001, it can be concluded that there is a significant effect of health education on knowledge. For attitudes the mean difference is 1.62 and the P value = 0.001, it can be concluded that there is a significant influence on health education on student attitudes. Therefore it is suggested to the school to include this topic in the subject matter. So students can apply it early and their reproductive health can be maintained.

Kadar estradiol serum pada wanita menopause dengan dan tanpa sindroma vasomotor di RSUP H Adam Malik dan RS Jejaring Fakultas Kedokteran Universitas Sumatera Utara Medan Tri Sugeng Hariadi; M. Fidel Ganis Siregar; Hanudse Hartono; Makmur Sitepu; M. Rhiza Z. Tala; Cut Adeya Adella
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 47, No 3 (2014): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Physiologic changes from the reproductive to non reproductive phase is characterized by a gradual decline in estrogen levels. In menopausal women decline of estrogen levels can causes various complaints, one of which is the vasomotor syndromeAim: This study was conducted to determine estradiol serum levels in menopausal women with and without vasomotor syndrome and estradiol serum levels in menopausal women based on severity degrees (mild, moderate, and severe).Metode: This analytical cross sectional study involved 60 women, 34 women with vasomotor syndrome and 26 women with non vasomotor syndrome. Serum estradiol levels in every groups were checked. Data were statistically analysed using Anova and Spearmen correlation tests (p<0.05; CI 95%).Results : Non vasomotor syndrome estradiol serum mean rank was significantly higher than vasomotor syndrome estradiol serum mean rank (17.5 vs 47,5 pg/mL). Mean estradiol levels of menopausal vasomotor syndrome subjects based on severity degrees for mild, moderate, and severe degrees are 25.80 ± 2.34 pg/ml; 15.58 ± 2.64 pg/ml; and 11,80 pg/ml (P<0.05). Age, menopausal age, and menopausal length was significantly negatively correlated with estradiol levels with r values of -0.859, - 0.830, and -0.880, respectively. Body Mass Index (BMI) was significantly positively correlated with estradiol levels with a r value of 0.699Conclusion: Serum estradiol levels were lower in vasomotor syndrome women than non vasomotor women. There is significantly differed serum estradiol levels based on severity degress. More severe degrees of vasomotor syndrome will make lowerv serum estradiol levels. Subject characteristics were also significantly associated with serum estradiol levels in menopausal women. Key Words : Menopause, vasomotor syndrome, serum estradiol.

Hubungan Genotipe DNA Human Papillomavirus (HPV) terhadap Respons Terapi Radiasi pada Karsinoma Sel Skuamosa Serviks CUT ADEYA ADELLA
Indonesian Journal of Cancer Vol 8, No 4 (2014): Oct - Dec 2014
Publisher : National Cancer Center - Dharmais Cancer Hospital

The importance of human papilloma virus (HPV) infection in the outcome of cervical cancer after radiotherapy remains unknown. Our study explored whether the HPV status of tumors is associated with the outcome of radiotherapy in patients with cervical cancer. The biopsy cervix samples taken from 31 patients with squamous cell carcinoma cervix (Stage IIB-IIIB) that met in the inclusion criteria. The HPV were genotyping examination was conducted twice before and 3 month after radiation therapy. The subjects treated by radiation therapy according to standard procedures. After undergone complete radiation, response of radiation therapy was conducted by clinical assessment and repeat HPV genotyping test. A total of 31 patients had HPV-positive tumors in 83.37% (27 cases) of patients, with the details of a single infection of 75% and 9:37% multiple infections. Based on the type of HPV type 16 was obtained (43.74%), type 18 (18.64%). Persistent infection with HPV after radiation encountered by 34.61%. Complete clinical response observed in the single infection group number of 100%, while in the group of multiple infections by 33.3% (p = 0.115). While HPV infection settled with a complete clinical response by 32% (p = 0.346). There were no statistically relationships between clinical complete response with single or multiple HPV infection (p = 0.115). There were no statistically relationship between persistent HPV infection with complete clinical response. (p = 0.346)

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