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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Majalah Obstetri dan Ginekologi Narra J International Journal of Educational Review, Law And Social Sciences (IJERLAS) JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Dwi Faradina
Department Of Obstetrics And Gynecology, Faculty Of Medicine, Universitas Sumatera Utara
Religion Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Public Health Social Sciences Other

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Abnormal Uterine Bleeding (AUB) at Haji Adam Malik General Hospital, Medan, North Sumatera, Indonesia Putri Ardina Sari Nainggolan; Muhammad Rusda; Dwi Faradina; Aridamuriany Dwiputri Lubis
Majalah Obstetri & Ginekologi Vol. 31 No. 1 (2023): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V31I12023.30-35

Abstract

HIGHLIGHTS Leiomyoma is still the most common case in women aged 41–50 years. Women who have an obese BMI are the main risk factor for abnormal uterine bleeding, so it is urged for women to maintain an ideal weight because it can be bad for health.   ABSTRACT Objective: This study identified the incidence of Abnormal Uterine Bleeding (AUB) at Haji Adam Malik General Hospital, Medan, Indonesia, in 2020-2021. Materials and Methods: This was a descriptive study with a cross-sectional design. Sampling was taken using total sampling and using retrospective data in the form of medical records with a diagnosis of AUB at Haji Adam Malik General Hospital Medan in 2020–2021. Results: There were 197 cases of AUB, with the highest distribution in the age group of 41–50 years with 84 people (42.6%). The most cases of AUB with an obese BMI were 91 people (46.2%), married status as many as 176 people (89.3%), had the last education level of senior high school as many as 99 people (50.3%), 144 people (73.1%) got their first menstruation when they were >12 years old, 80 people (40.6%) had multiparity, 90 people (45.7%) received medical therapy. Based on the PALM-COEIN classification, the most AUB cases were AUB-L with 99 people (50.3%). Based on the classification of AUB-L locations, most locations were submucosa with 38.6%. Conclusion: AUB-L cases were still the most common cases at Haji Adam Malik General Hospital, Medan, Indonesia, in 2020–2021.
GENERAL OVERVIEW OF HEALTH LAW IN INDONESIA Dwi Faradina; Tri Faranita; Henry Aspan
International Journal of Educational Review, Law And Social Sciences (IJERLAS) Vol. 4 No. 2 (2024): March
Publisher : RADJA PUBLIKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54443/ijerlas.v4i2.1561

Abstract

Initially, health development relied on efforts to treat disease and restore health, shifting to implementing comprehensive health efforts with an emphasis on efforts to prevent disease and improve health. Adequate health legal instruments are intended to provide legal certainty and comprehensive protection for both providers of health efforts and communities receiving health services. The legal basis for health is regulated in Law Number 36 of 2009 concerning health. Health Law is all legal provisions that relate directly to health maintenance/services. This concerns the rights and obligations of receiving health services (both individuals and levels of society) as well as the implementation of health services in all its aspects, organization, facilities, medical service standards and so on. A Health Worker is any person who dedicates themselves to the health sector and has knowledge and/or skills through education in the health sector, which for certain types requires authority to carry out health efforts. As legal subjects, actors in the health sector such as doctors, dentists, hospital directors, heads of health services, heads of divisions, heads of community health centers always carry out legal actions. Legal actions taken if they conflict with applicable regulations will result in legal sanctions.
Correlation between serum vitamin D levels and bone mass density evaluated by radiofrequency echographic multi-spectrometry technology (REMS) in menopausal women Siregar, M. Fidel G.; Jabbar, Feisal; Effendi, Iman H.; Alhair, Tanzil; Prabudi, Muhammad O.; Faradina, Dwi
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.452

Abstract

Osteoporosis is a common condition associated with an increased risk of bone fractures due to fragility. Bone mineral density (BMD) is lower in menopausal women due to estrogen deficiency, age-related decline in osteoblast function, decreased calcium absorption, and reduced synthesis of vitamin D, which lead to osteoporosis. The aim of this study was to determine the correlation between serum vitamin D levels and BMD assessed using radiofrequency echographic multi-spectrometry technology (REMS) in menopausal women. A cross-sectional study was conducted at Prof. Dr. Chairuddin P. Lubis Hospital of Universitas Sumatera Utara, Medan, Indonesia, from May 2023 to August 2023. Consecutive sampling method was employed to sample menopausal women with no history of hysterectomy or oophorectomy (unilateral or bilateral), and no history of hormone replacement therapy or vitamin D supplementation. Interviews and physical examinations were conducted to obtain the characteristics of the subjects (age, duration of menopause, and body mass index). The 25(OH)D level was measured using immunoassay and REMS examination was conducted to assess BMD. The Spearman correlation test was used to assess the correlation between serum vitamin D levels and BMD. A total of 32 menopausal women were included in this study with the average vitamin D level was 18.05±5.81 ng/mL, and the mean BMD level was -2.13±1.23. The data showed a significant positive correlation between serum vitamin D levels and BMD in menopausal women (r=0.710; p=0.020). This study highlights that REMS could be useful as an alternative to dual-energy x-ray absorptiometry (DXA) to assess DMD in postmenopausal women.
Promotive and Preventive Programs for Health Workers and Mothers on Newborn Umbilical Cord Care to Prevent Infection During the Neonatal Period Wahyuni, Fera; Lubis, Syamsidah; Faradina, Dwi; Husada, Muhammad Surya
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 10, No 3 (2024): September
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.94860

Abstract

Umbilical cord infections can be prevented by caring for the umbilical cord properly. The data regarding proper and correct umbilical cord care of newborn babies by mothers in North Sumatra Province is limited. Hence, this community service aimed to determine the proportion of knowledge in umbilical cord care for newborn babies using the open-dry cord care method. Thew community service project was held on August 24, 2023, in Pematang Siantar City, North Sumatra Province. In this activity, we provided counseling on the open-dry cord care method for umbilical cord care by presentation and discussion using modules, posters, and leaflets. We used a pre-test and post-test questionnaire to assess the knowledge level of health workers and mothers. Participant demographic data and results are presented in the form of proportion data. This counseling was attended by 150 participants consisting of 52 health workers and 98 mothers. Before the counseling, 39 health workers and 93 mothers did not know how to take care of the umbilical cord properly. After the counseling, the knowledge of umbilical cord care using the open-dry cord method increased by 15.4% for health workers and 24.5% for mothers. Based on the results, over 80% of participants were found to have had a satisfactory level of knowledge about umbilical cord care after the counseling session. This community service program should be conducted regularly to further enhance the knowledge of health workers and mothers on proper umbilical cord care.
Effect of Nigella sativa seed extract on estradiol, FSH levels, and vaginal maturity index in menopausal women: A randomized controlled trial Sukatendel, Khairani; Hasibuan, Reni H.; Siregar, Muhammad FG.; Faradina, Dwi; Edianto, Deri; Lintang, Letta S.; Rusda, Muhammad; Inriani, Vega
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1399

Abstract

Nigella sativa seed extract has been shown to have a significant effect on endometrial thickness and vaginal cytology in ovariectomized animal models, suggesting potential benefits for managing menopausal symptoms. However, to the best of the author’s knowledge, no human studies have been done to support these conclusions. The aim of this study was to investigate the effects of N. sativa seed extract on estradiol, follicle-stimulating hormone (FSH), and the vaginal maturity index (VMI) in postmenopausal women. A single-blinded, randomized placebo-controlled experiment was carried out at Haji Adam Malik Hospital, Medan, Indonesia, with 50 eligible postmenopausal women patients randomized into three groups. Group 1 received a placebo, while groups 2 and 3 were given N. sativa seed extract at 910 mg/day and 1,365 mg/day, respectively. All participants were blinded to the treatment they received. The study used Shad Nigella Plus, an Indonesian herbal medicine containing 455 mg of N. sativa seed extract per capsule. Before the treatments, estradiol levels, FSH levels, and VMI were measured at baseline and remeasured after eight weeks of treatment. Two participants in the intervention group withdrew due to nausea, a reported side effect of N. sativa seed extract consumption. Both treatment groups showed significant increases in estradiol levels (p=0.01 and p=0.001) and VMI (p=0.004 and p=0.001) after eight weeks of daily N. sativa seed extract administration compared to the placebo group. However, no significant differences were found between the two doses in estradiol levels and VMI (p=0.12 and p=0.673, respectively). Moreover, FSH levels showed no significant difference throughout both interventions (p=0.53 and p=0.96, respectively). In conclusion, twice-daily N. sativa seed extract at 910 mg/day or 1,365 mg/day for eight weeks significantly increased estradiol levels and VMI in menopausal women but had no significant effect on FSH levels. These findings support the potential role of N. sativa seed extract as a natural treatment for menopausal symptoms.
Pengaruh Pemberian Esomeprazole Terhadap Ekspresi Imunohistokimia Soluble Fms-Like Tyrosine Kinase (Sflt-1) Dan Soluble Endoglin (Seng) Pada Tikus Dengan Model Preeklamsia Andri, Sofyan; Aldiansyah, Dudy; Dina, Sarah; Marpaung, Johny; Adenin, Ichwanul; Faradina, Dwi
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.66-76

Abstract

Preeclampsia is a systemic disorder affecting approximately 3–8% of pregnant women, occurring during or after pregnancy. The exact cause and underlying mechanisms of this condition remain unclear. It is believed that the anti-angiogenic molecules soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng), which are excessively produced by the placenta in preeclampsia, play a significant role in endothelial dysfunction. Recent studies suggest that esomeprazole, a proton pump inhibitor, is generally well tolerated in preeclamptic patients. This study aimed to evaluate the effect of esomeprazole administration on the reduction of sFlt-1 and sEng expression in a preeclampsia-induced rat model using an analytical approach with a quasi-experimental design. The research was conducted at two laboratories within the Faculty of Medicine and the Faculty of Mathematics and Natural Sciences at Universitas Sumatera Utara: the Anatomical Pathology Laboratory and the Biology Laboratory. The study subjects consisted of 30 healthy and active female laboratory rats (Rattus norvegicus), aged 10 weeks, modeled to resemble preeclamptic conditions. The study was carried out in May 2021. After the intervention, significant differences were observed between the intervention and control groups in systolic blood pressure, diastolic blood pressure, and mean arterial pressure (MAP) (p = 0.001; p = 0.014; p = 0.001). Additionally, the proportion of proteinuria was lower in the intervention group than in the control group. The mean expression levels of sFlt-1 and sEng also showed statistically significant differences between the intervention and control groups (p = 0.002; p = 0.001). The findings indicate statistically significant changes in MAP, systolic and diastolic blood pressure, and proteinuria across all groups following the intervention. A comparison of sFlt-1 and sEng expression levels among the negative control, positive control, and intervention groups revealed statistically significant differences. Esomeprazole administration at a dosage of 4.68 mg/kgBW/day significantly reduced sFlt-1 expression, demonstrating the therapeutic potential of esomeprazole in suppressing anti-angiogenic factors in preeclampsia.
IN VITRO EVALUATION OF PHYTOCHEMICAL COMPOUND FOR ANTIBACTERIAL ACTIVITY AT MURRAYA KOENIGII LEAF EXTRACT AGAINST THE GROWTH OF ESCHERICHIA COLI Elbert, Elbert; Adella, Cut Adeya; Faradina, Dwi; Lubis, Lokot Donna; Khosasi, Felix
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 11 No 1 (2024): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 11.1 (2024)
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v11i1.767

Abstract

Introduction: In developing nations, like Indonesia, urinary tract infection, or UTI, is a frequent infection in women that results from the growth of microorganisms in the urinary tract. Escherichia coli is the most common cause. Antibiotics are the major form of treatment; however, misuse of these drugs has led to resistance. Innovation in potential medical plants is crucial. The curry leaf plant (Murraya koenigii) is one of them. Methods: The agar diffusion method was used to assess antibacterial activity. Murraya koenigii leaves were gathered from a garden in Tanjong Morawa. Escherichia coli ATCC 25922 is the type of bacteria that is used. Using 96% ethanol as the solvent, Murraya koenigii leaves were extracted using the maceration method. There were six treatments with concentrations of 6.25%, 12.5%, 25%, and 50%, positive control levofloxacin, and negative control DMSO. Results: The results of the phytochemical screening of the extracts showed that metabolites like flavonoids, tannins, and triterpenes had antibacterial effects. Data on the diameter of the inhibition zone were examined using the Kruskal-Wallis statistical test. The findings demonstrated that all treatments had statistically significant differences (p<0.05). Discussions: The presence of compounds such as flavonoids, tannins, and triterpenes in curry leaf extract has an antibacterial effect on Escherichia coli. This compound can prevent the creation of nucleic acids, inhibit cell membrane function, damage the permeability of bacterial cells, and deactivate bacterial enzymes. Conclusion: The ethanol extract of curry leaves has an inhibitory effect on the growth of Escherichia coli bacteria.
IN VITRO EVALUATION OF THE ANTIBACTERIAL POTENTIAL OF PSIDIUM GUAJAVA LEAF EXTRACT AGAINST ESCHERICHIA COLI: UNCOVERING THE ROLE OF PHYTOCHEMICAL COMPOUNDS. Khosasi, Felix; Adella, Cut Adeya; Faradina, Dwi; Lubis, Lokot Donna; Elbert, Elbert
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 10 No 3 (2024): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 10.3 2024
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v10i3.765

Abstract

Introduction: Urinary tract infections (UTIs) are prevalent among women and are commonly caused by Escherichia coli. Although antibiotics are effective, their misuse contributes to rising antimicrobial resistance. Psidium guajava L., a traditional Indonesian medicinal plant, has shown promise as an alternative antibacterial agent. This study aimed to evaluate the inhibitory effect of P. guajava leaf extract against E. coli. Methods: Antibacterial activity was assessed using the agar diffusion method with E. coli ATCC 25922. Ethanolic extracts were obtained by maceration. Six treatment groups, including various concentrations of levofloxacin and dimethyl sulfoxide (DMSO), were tested to compare antibacterial effects. Results: Phytochemical screening revealed the presence of flavonoids, alkaloids, and tannins—compounds known for their antimicrobial activity. Inhibition zone diameters were measured and analysed using the Kruskal–Wallis one-way ANOVA. Discussion: The guava leaf extract demonstrated inhibitory activity against E. coli, likely due to its bioactive compounds. These constituents may exert antibacterial effects through disruption of nucleic acid synthesis, interference with membrane integrity, inhibition of energy metabolism, and prevention of biofilm formation. Conclusion: The ethanolic extract of Psidium guajava leaves exhibits significant antibacterial activity against Escherichia coli.
Co-Authors Adenin, Ichwanul Aldiansyah, Dudy Alhair, Tanzil Aridamuriany Dwiputri Lubis CUT ADEYA ADELLA, CUT ADEYA Deri Edianto Dina, Sarah Effendi, Iman H. Elbert, Elbert Hasibuan, Reni H. Henry Aspan Husada, Muhammad Surya Inriani, Vega Jabbar, Feisal Khosasi, Felix Lintang, Letta S. Lokot Donna Lubis, Lokot Donna Marpaung, Johny Muhammad Rusda Prabudi, Muhammad O. Putri Ardina Sari Nainggolan Rusda, Muhammad Siregar, M. Fidel G. Siregar, Muhammad FG. Sofyan Andri Sukatendel, Khairani Syamsidah Lubis, Syamsidah Tri Faranita Wahyuni, Fera