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All Journal JURNAL SIPAKALEBBI MPI (Media Pharmaceutica Indonesiana) Indonesian Journal of Community Empowerment
Pratiwi, Afryanti
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Agriculture, Biological Sciences & Forestry Humanities Chemistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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MICROBIOLOGICAL INFECTION RISKS AMONG CHILDREN IN SUB-URBAN SETTLEMENT OF MAKASSAR Hafsan, Hafsan; Anggraeni, Rini; Pratiwi, Afryanti
JURNAL SIPAKALEBBI Vol 9 No 1 (2025): Juni
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/sipakallebbi.v9i1.56899

Abstract

Microbiological infections in children are still a significant health problem, especially in sub-urban environments with suboptimal sanitation infrastructure. Environmental factors and hygiene habits play a big role in increasing or decreasing the risk of infection. This study aims to analyze the relationship between home sanitation conditions, housing density, children's hygiene habits, and the incidence of microbiological infections in children in Bontote'ne Housing, Makassar. This study uses an analytical descriptive study design with a cross-sectional approach. A total of 50 children aged 5–12 years and their parents participated as respondents. Data were collected through questionnaires regarding environmental factors, children's hygiene habits, and history of microbiological infections. The analysis was performed using Chi-Square tests and logistic regression to identify the relationship between independent variables and bound variables. The results showed that poor sanitation, high residential density, and inadequate handwashing practices were significantly associated with increased rates of gastrointestinal, respiratory, and diarrhoeal infections. Handwashing with soap was identified as a key protective factor.This study confirms that environmental factors and hygiene habits have an important role in the incidence of microbiological infections in children. Public health interventions such as improving sanitation infrastructure, improving access to clean water, and ongoing hygiene education are needed to reduce the risk of infection in sub-urban environments.
EDUKASI PENYAKIT KECACINGAN PADA SISWA SDN 34 KOTA KENDARI: INFORMASI DAN PENCEGAHAN Ilyas Y., Muhammad; Akib, Nur Illyyin; Jabbar, Asriullah; Halik, Halik; Masempo, Mustawakal; Aprilia, Sitti Aisyah; Yuqqabad, Yuqqabad; Erika, Erika; Pratiwi, Afryanti; Rusli, Nirwati; Badia, Esti; Nurhikma, Nurhikma
MAJU : Indonesian Journal of Community Empowerment Vol. 2 No. 4 (2025): MAJU : Indonesian Journal of Community Empowerment, Juli 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/maju.v2i4.1370

Abstract

Soil-transmitted helminthiases (STH) infections are one of the most common types of infections worldwide, with an estimated 1.5 billion people infected, accounting for 24% of the world's population. According to data from the WHO in 2024, more than 260 million pre-school children and 654 million school-aged children in Indonesia are vulnerable to helminthiasis infection. They are in urgent need of treatment and preventive interventions. Helminthiasis in children leads to a decline in their health and nutritional status, resulting in impaired growth, development, and physical and psychological activity. The purpose of this activity was to educate students of SD 34 Kendari class 3A about helminthiasis. This activity was carried out using the lecture method, providing leaflets and educational videos by lecturers, practitioners, and pharmacist professional students of the 13th batch of the Faculty of Pharmacy UHO, in collaboration with SDN 34 Kendari school, Puuwatu District, Kendari City. The results of this activity contributed to increasing the knowledge and understanding of students of SDN 34 Kendari about helminthiasis and how to prevent it.  
Molecular Docking Analysis of Compounds in Coleus blumei Leaves as Potential Antibiotics Against Methicillin-Resistant Staphylococcus aureus Sukmawaty, Eka; Amanda, Sabilla Suryaning; Hafsan; Nur, Fatmawati; Pratiwi, Afryanti
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 2 (2025): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i2.7419

Abstract

This study investigated the potential of phytochemical compounds from Coleus blumei leaves as anti-Methicillin-Resistant Staphylococcus aureus (MRSA) candidates through a validated molecular docking and absorption-distribution-metabolism-excretion-toxicology (ADMET)-based screening approach. The ligand structures were energy-minimized using MMFF94 followed by PM7 to obtain stable conformers prior to docking. Protein targets consisted of PBP2a and the extracellular antibiotic-sensing domain of MecR1 (benzylpenicilloyl- and oxacilloyl-acylated forms), both of which play central roles in the mecA-mediated resistance pathway of MRSA. Docking simulations were performed using AutoDock Vina v1.2.7 and validated through redocking of co-crystallized ligands, yielding RMSD values <2.0 Å. Among the eight tested compounds, Hexahydro-3H-1[2’-trifluoromethyl]-6’[4’’-trifluoromethylphenyl]- exhibited the strongest binding affinities, surpassing reference β-lactam antibiotics and demonstrating key interactions with residues involved in allosteric activation of PBP2a and ligand sensing in MecR1. ADMET predictions further supported its drug-likeness and safety profile, although experimental confirmation remains necessary. These findings highlight this compound as a promising anti-MRSA lead candidate and underscore the need for subsequent in vitro and in vivo evaluations to substantiate its mechanistic and therapeutic potential.
PERSPEKTIF NEUROBIOLOGI KORBAN KEKERASAN SEKSUAL DAN TANGGUNG JAWAB MORAL DALAM ISLAM (MINI REVIEW) Hafsan, Hafsan; Firdaus, Firdaus; Pratiwi, Afryanti
JURNAL SIPAKALEBBI Vol 9 No 2 (2025): Desember
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Sexual violence on university campuses represents a multidimensional crisis that violates not only moral integrity but also inflicts deep and lasting biological damage on survivors. Neurobiological research reveals that trauma from sexual violence can alter the structure and function of the brain, particularly the amygdala, hippocampus, and prefrontal cortex which are critical for emotional regulation, memory, and decision-making. Disruptions in these brain systems may lead to long-term conditions such as dissociation, chronic anxiety, and post-traumatic stress disorder (PTSD). In the Indonesian academic context, sexual violence often remains concealed behind institutional hierarchies, power imbalances, and a normalized culture of silence, as reflected in various studies and official reports. This article integrates findings from neuroscience with Islamic ethical principles to formulate a holistic approach to victim protection and recovery. Islam, through the framework of maqāṣid al-sharī‘ah, upholds personal dignity (al-‘irḍ) as a fundamental value that must be safeguarded. Social responsibility to protect survivors and prevent injustice is strongly emphasized in the Qur'an and prophetic tradition. Thus, the Islamic response to sexual violence goes beyond legalism, encompassing spiritual, biological, and psychosocial dimensions. In this view, an integrative framework combining scientific insight and moral-spiritual values is essential to build a just, compassionate, and trauma-informed response to sexual violence on campus. Kekerasan seksual di lingkungan kampus merupakan krisis multidimensi yang tidak hanya mencederai integritas moral, tetapi juga meninggalkan dampak biologis yang mendalam bagi korban. Kajian neurobiologi menunjukkan bahwa trauma akibat kekerasan seksual dapat mengubah struktur dan fungsi otak, terutama pada area seperti amigdala, hipokampus, dan prefrontal cortex, yang berperan dalam pengaturan emosi, memori, dan pengambilan keputusan. Gangguan pada sistem saraf ini tidak jarang menghasilkan gejala jangka panjang seperti disosiasi, kecemasan kronis, dan gangguan stres pascatrauma (PTSD). Dalam konteks akademik di Indonesia, kasus-kasus kekerasan seksual sering tersembunyi di balik relasi kuasa, hierarki institusional, dan normalisasi budaya diam, sebagaimana terbaca dalam sejumlah laporan riset dan catatan lembaga negara. Artikel ini memadukan temuan-temuan ilmu saraf dengan etika Islam untuk merumuskan pendekatan holistik dalam perlindungan dan pemulihan korban. Islam, melalui kerangka maqāṣid al-syarī‘ah, menempatkan kehormatan (al-‘irḍ) sebagai nilai yang harus dijaga secara serius. Tanggung jawab sosial untuk melindungi korban dan mencegah kezaliman ditegaskan dalam ajaran Al-Qur’an dan hadis. Maka, penanganan kekerasan seksual dalam kerangka Islam tidak hanya bersifat legalistik, tetapi juga menyentuh aspek spiritual, biologis, dan psikososial secara integral. Dengan demikian, dibutuhkan integrasi antara sains dan nilai moral sebagai fondasi respons yang lebih adil, manusiawi, dan menyembuhkan.  
Co-Authors Akib, Nur Illyyin Amanda, Sabilla Suryaning Aprilia, Sitti Aisyah Badia, Esti Chatarina Umbul Wahyuni Erika Erika Fatmawati Nur Firdaus Firdaus Hafsan Hafsan, Hafsan Ilyas Y., Muhammad Jabbar, Asriullah Masempo, Mustawakal Nurhikma, Nurhikma Rini Anggraeni Rusli, Nirwati Sukmawaty, Eka Yuqqabad, Yuqqabad